Primary hepatic neuroendocrine carcinoma

Primary hepatic neuroendocrine carcinoma (PHNEC) is a rare hepatic tumor that may manifest with abdominal pain or fullness, as well as diarrhea or weight loss. More than 10% of cases are asymptomatic and in rare cases a carcinoid syndrome may be observed.

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Narrow down the case reports

Total: 22 (papers)

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Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (4.0%)	29507528 (5831736)	Primary hepatic neuroendocrine carcinoma: report of two cases and literature review. Zhao ZM, Wang J, Ugwuowo UC, Wang L, Townsend JP. BMC Clin Pathol. 2018;18:3. [ Show abstract ] [ Hide abstract ]
		Jaundice



1 (4.0%)	28647212	Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course): A case report. Okumura Y, Kohashi K, Wang H, Kato M, Maehara Y, Ogawa Y, Oda Y. Pathol Res Pract. 2017;213(10):1322-1326. [ Show abstract ] [ Hide abstract ]
		Carcinoma


		Biopsy Carcinoma, Neuroendocrine Chemoembolization, Therapeutic Disease Progression Embolization, Therapeutic Fatal Outcome Hepatectomy Homo sapiens Immunohistochemistry Male Neoplasms, Complex and Mixed
1 (4.0%)	27895410 (5107604)	Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature. Choi GH, Ann SY, Lee SI, Kim SB, Song IH. World J Gastroenterol. 2016;22(41):9229-9234. [ Show abstract ] [ Hide abstract ]
		Carcinoma


		Antineoplastic Combined Chemotherapy Protocols Biopsy Carcinoma, Neuroendocrine Hepatectomy Homo sapiens Immunohistochemistry Laparoscopy Magnetic Resonance Imaging Male Neoplasm Recurrence, Local Neoplasms, Multiple Primary Palliative Care
1 (4.0%)	27554219	[A Case of Composite Hepatocellular Carcinoma and Neuroendocrine Carcinoma in a Patient with Liver Cirrhosis Caused by Chronic Hepatitis B]. Yun EY, Kim TH, Lee SS, Kim HJ, Kim HJ, Jung WT, Lee OJ, Song DH. Korean J Gastroenterol. 2016;68(2):109-13. [ Show abstract ] [ Hide abstract ]
		Aggressive behavior


		Abdomen CD56 Antigens Carcinoma, Neuroendocrine Females Hepatitis B, Chronic Homo sapiens Immunohistochemistry Liver Cirrhosis Magnetic Resonance Imaging
1 (4.0%)	27384317	Histological features of mixed neuroendocrine carcinoma and hepatocellular carcinoma in the liver: a case report and literature review. Nishino H, Hatano E, Seo S, Shibuya S, Anazawa T, Iida T, Masui T, Taura K, Haga H, Uemoto S. Clin J Gastroenterol. 2016;9(4):272-9. [ Show abstract ] [ Hide abstract ]
		Lymphadenopathy


		Carcinoma, Neuroendocrine Hepatectomy Homo sapiens Magnetic Resonance Imaging Male Neoplasms, Multiple Primary X-Ray Computed Tomography
1 (4.0%)	26184027	Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule. Kano Y, Kakinuma S, Goto F, Azuma S, Nishimura-Sakurai Y, Itsui Y, Nakagawa M, Kudo A, Tanabe M, Kirimura S, Amano T, Ito T, Akashi T, Asahina Y, Watanabe M. Clin J Gastroenterol. 2014;7(5):449-54. [ Show abstract ] [ Hide abstract ]
		Carcinoma


		Bile Duct Neoplasms Carcinoma, Neuroendocrine Cholangiocarcinoma Homo sapiens Male Neoplasms, Multiple Primary
1 (4.0%)	26161177 (4484323)	Hepatic primary neuroendocrine carcinoma: about a new case. Derouich H, Haddad F, Moukhlissi M, Hliwa W, Bellabah A, Badre W. Pan Afr Med J. 2015;20:254. [ Show abstract ] [ Hide abstract ]
		Carcinoma


		Abdominal Pain Antineoplastic Combined Chemotherapy Protocols Biopsy Carcinoma, Neuroendocrine Follow-Up Studies Homo sapiens Male Middle Aged Remission Induction
1 (4.0%)	26155210 (4304509)	Primary hepatic neuroendocrine carcinoma. Kim JM, Kim SY, Kwon CH, Joh JW, Park JB, Lee JH, Kim SJ, Park CK. Korean J Hepatobiliary Pancreat Surg. 2013;17(1):34-7. [ Show abstract ] [ Hide abstract ]
		Aspiration



1 (4.0%)	25051214	Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma. Rasmussen JO, von Holstein SL, Prause JU, Vainer B, Hansen AB, Fehr A, Stenman G, Heegaard S. Oncol Rep. 2014;32(4):1447-50. [ Show abstract ] [ Hide abstract ]
		Proptosis


		Carcinoma, Neuroendocrine Chromosome Aberrations Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 18 Chromosomes, Human, Pair 3 Females Homo sapiens Orbital Neoplasms
1 (4.0%)	24146337	Surgery for giant primary neuroendocrine carcinoma of the liver. Sotiropoulos GC, Charalampoudis P, Delladetsima I, Stamopoulos P, Dourakis S, Kouraklis G. J Gastrointest Surg. 2014;18(4):839-41. [ Show abstract ] [ Hide abstract ]
		Hemangioma
		COX8A

		Carcinoma, Neuroendocrine Females Homo sapiens Ki-67 Antigen Tumor Burden Young Adult

Phenotype(s) retrieved from Orphanet

Total: 38

HPO ID	Term	Frequency
HP:0002896	Neoplasm of the liver	Obligate (100%)
HP:0100634	Neuroendocrine neoplasm	Obligate (100%)
HP:0001541	Ascites	Frequent (79-30%)
HP:0001824	Weight loss	Frequent (79-30%)
HP:0002014	Diarrhea	Frequent (79-30%)
HP:0002018	Nausea	Frequent (79-30%)
HP:0002039	Anorexia	Frequent (79-30%)
HP:0002094	Dyspnea	Frequent (79-30%)
HP:0002240	Hepatomegaly	Frequent (79-30%)
HP:0002574	Episodic abdominal pain	Frequent (79-30%)
HP:0002730	Chronic noninfectious lymphadenopathy	Frequent (79-30%)
HP:0002910	Elevated hepatic transaminase	Frequent (79-30%)
HP:0003270	Abdominal distention	Frequent (79-30%)
HP:0012432	Chronic fatigue	Frequent (79-30%)
HP:0001407	Hepatic cysts	Occasional (29-5%)
HP:0001708	Right ventricular failure	Occasional (29-5%)
HP:0001962	Palpitations	Occasional (29-5%)
HP:0002480	Hepatic encephalopathy	Occasional (29-5%)
HP:0003144	Increased serum serotonin	Occasional (29-5%)
HP:0007380	Facial telangiectasia	Occasional (29-5%)
HP:0025428	Bronchospasm	Occasional (29-5%)
HP:0025474	Erythematous plaque	Occasional (29-5%)
HP:0030148	Heart murmur	Occasional (29-5%)
HP:0030166	Night sweats	Occasional (29-5%)
HP:0100570	Carcinoid tumor	Occasional (29-5%)
HP:0000508	Ptosis	Very rare (4-1%)
HP:0001046	Intermittent jaundice	Very rare (4-1%)
HP:0004375	Neoplasm of the nervous system	Very rare (4-1%)
HP:0005230	Biliary tract obstruction	Very rare (4-1%)
HP:0006575	Intrahepatic cholestasis with episodic jaundice	Very rare (4-1%)
HP:0007663	Reduced visual acuity	Very rare (4-1%)
HP:0010638	Elevated alkaline phosphatase of hepatic origin	Very rare (4-1%)
HP:0012658	Abnormal brain FDG positron emission tomography	Very rare (4-1%)
HP:0030948	Elevated gamma-glutamyltransferase activity	Very rare (4-1%)
HP:0100012	Neoplasm of the eye	Very rare (4-1%)
HP:0100526	Neoplasm of the lung	Very rare (4-1%)
HP:0006254	Elevated alpha-fetoprotein	Excluded (0%)
HP:0031029	Elevated carcinoembryonic antigen level	Excluded (0%)

Phenotype(s) retrieved from case reports

Total: 10

HPO ID	Term	# of case reports
HP:0000520	Proptosis	1
HP:0001028	Hemangioma	1
HP:0001298	Encephalopathy	1
HP:0012115	Hepatitis	1
HP:0030731	Carcinoma	1
HP:0031181	Necrolytic migratory erythema	1
HP:0031284	Flushing	1
HP:0100523	Liver abscess	1
HP:0100584	Endocarditis	1
HP:0410019	Epigastric pain	1

Causative gene(s) retrieved from Orphanet

Total: 0

Gene Symbol	Gene Name	Entrez Gene ID