Carcinoid syndrome

A rare neoplastic disease characterized by the occurrence of a hormonal syndrome resulting from secretion of humoral factors (including polypeptides, vasoactive amines, and prostaglandins) from a functional neuroendocrine tumor (particularly from the midgut), typically manifesting with increased bowel movements and diarrhea, episodic vasoactive flushes (particularly of the face), hypotension, tachycardia, venous telangiectasia, dyspnea, and bronchospasms, as well as long-term fibrotic changes in the mesentery, retroperitoneum, and of the cardiac valves.



Input patient's signs and symptoms


Narrow down the case reports



Total: 423 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
1
(54.2%)
12749224
Carcinoid of the papilla of Vater; a case report.
Suzuki H, Kuwano H, Masuda N, Tuboi K, Wada S, Saitoh T, Kanoh K, Nomoto K, Shimura T.
Hepatogastroenterology. 2003;50(50):371-3.
Jaundice Anemia Glucose intolerance
Ampulla of Vater Carcinoid Tumor Chromogranin A Chromogranins Common Bile Duct Neoplasms Homo sapiens Immunohistochemistry Male Pancreaticoduodenectomy
2
(49.1%)
26681999
(4675029)
Urticaria as initial finding of a patient with carcinoid tumor.
Cherrez Ojeda I, Calderon JC, Plaza K, Vanegas E, Cherrez A, Cano J.
World Allergy Organ J. 2015;8(1):34.
Urticaria Anemia Angioedema
GAST
3
(42.4%)
8525344
[Pruritus--also a challenge in internal medicine].
Brunner W.
Schweiz Med Wochenschr. 1995;125(46):2244-50.
Diabetes mellitus Cholestasis Leukemia
Adult Cholangitis, Sclerosing Differential Diagnosis Females Hematological Disease Hodgkin Disease Homo sapiens Male Metabolic Diseases Middle Aged Polycythemia Vera Pruritus Uremia
4
(38.6%)
30878964
Vitamin D and vitamin B12 deficiencies in patients with small intestinal carcinoid tumour: is opioid use disorder a confounding factor in the diagnosis?
Fagan R, Bokhari SSN, Inayat F.
BMJ Case Rep. 2019;12(3):.
Intestinal carcinoid Flushing Vitamin B12 deficiency
NDUFB3
Carcinoma, Neuroendocrine Homo sapiens Ileal Neoplasms Laparotomy Male Middle Aged Opioid-Related Disorders Vitamin B 12 Deficiency Vitamin D Deficiency
5
(37.5%)
30590945
Multiple neuroendocrine tumor of the small bowel: acase report and areview of literature.
Kunovsky L, Dastych M, Robek O, Svaton R, Vlazny J, Husty J, Eid M, Poredska K, Kysela P, Kala Z.
Vnitr Lek. 0000;64(10):966-969.
Weight loss Hypochromic anemia Diarrhea
CHGA
Aged, 80 and over Capsule Endoscopy Gastrointestinal Hemorrhage Homo sapiens Intestinal Neoplasms Intestines, Small Male Neuroendocrine Tumors
5
(37.5%)
23547726
Intestinal ischaemia associated with carcinoid tumor: a case report with review of the pathogenesis.
Yener O.
Prague Med Rep. 2013;114(1):43-7.
Anemia Abdominal pain
Adult Carcinoid Tumor Homo sapiens Ileal Neoplasms Intestines Ischemia Male
5
(37.5%)
23043903
(5098702)
The various faces of autoimmune endocrinopathies: non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis.
Melcescu E, Hogan RB 2nd, Brown K, Boyd SA, Abell TL, Koch CA.
Exp Mol Pathol. 2012;93(3):434-40.
Overgrowth Anemia Diarrhea
CHGA GAST
Autoimmune Diseases Colitis, Lymphocytic Differential Diagnosis Digestive System Neoplasms Females Gastrinoma Gastrins Gastritis, Atrophic Homo sapiens Middle Aged Neuroendocrine Tumors
5
(37.5%)
16830392
Treatment of solitary gastric carcinoid tumor by endoscopic polypectomy in a patient with pernicious anemia.
Kadikoylu G, Yavasoglu I, Yukselen V, Ozkara E, Bolaman Z.
World J Gastroenterol. 2006;12(26):4267-9.
Anemia Gastritis
CHGA GAST SYP
Anemia, Pernicious Carcinoid Tumor Females Gastrins Homo sapiens Middle Aged Stomach Neoplasms
5
(37.5%)
9299920
Gastric carcinoid tumour. A clinicopathologic and immunohistochemical study of four cases.
Oncins R, De Escalante B, Villalta J, Candeal JM, Harb Y, Riu F.
Rev Esp Enferm Dig. 1997;89(8):611-20.
Iron deficiency anemia Chronic atrophic gastritis
CHGA
Carcinoid Tumor Females Gastritis, Atrophic Homo sapiens Immunohistochemistry Male Middle Aged Stomach Neoplasms
5
(37.5%)
7959559
Gastric carcinoid: a rare form of gastrointestinal carcinoids. A report on three cases.
Teh CH, Low CH.
Hepatogastroenterology. 1994;41(3):298-301.
Anemia Hematemesis
Carcinoid Tumor Follow-Up Studies Gastrectomy Homo sapiens Male Middle Aged Stomach Neoplasms
        

Phenotype(s) retrieved from Orphanet

    Total: 27

HPO ID Term Frequency
HP:0100570 Carcinoid tumor Obligate (100%)
HP:0002574 Episodic abdominal pain Frequent (79-30%)
HP:0004385 Protracted diarrhea Frequent (79-30%)
HP:0006722 Small intestine carcinoid Frequent (79-30%)
HP:0006723 Intestinal carcinoid Frequent (79-30%)
HP:0025474 Erythematous plaque Frequent (79-30%)
HP:0030166 Night sweats Frequent (79-30%)
HP:0001708 Right ventricular failure Occasional (29-5%)
HP:0001962 Palpitations Occasional (29-5%)
HP:0002017 Nausea and vomiting Occasional (29-5%)
HP:0002099 Asthma Occasional (29-5%)
HP:0002730 Chronic noninfectious lymphadenopathy Occasional (29-5%)
HP:0002910 Elevated hepatic transaminase Occasional (29-5%)
HP:0003144 Increased serum serotonin Occasional (29-5%)
HP:0005180 Tricuspid regurgitation Occasional (29-5%)
HP:0007380 Facial telangiectasia Occasional (29-5%)
HP:0009926 Epiphora Occasional (29-5%)
HP:0025428 Bronchospasm Occasional (29-5%)
HP:0030148 Heart murmur Occasional (29-5%)
HP:0030445 Pulmonary carcinoid tumor Occasional (29-5%)
HP:0031138 Abnormal B-type natriuretic peptide level Occasional (29-5%)
HP:0031417 Rhinorrhea Occasional (29-5%)
HP:0002605 Hepatic necrosis Very rare (4-1%)
HP:0002668 Paraganglioma Very rare (4-1%)
HP:0003198 Myopathy Very rare (4-1%)
HP:0030145 Lack of bowel sounds Very rare (4-1%)
HP:0030446 Atypical pulmonary carcinoid tumor Very rare (4-1%)


Phenotype(s) retrieved from case reports

    Total: 100

HPO ID Term # of case reports
HP:0100570 Carcinoid tumor 60
HP:0031284 Flushing 49
HP:0002014 Diarrhea 25
HP:0002027 Abdominal pain 12
HP:0002664 Neoplasm 9
HP:0025428 Bronchospasm 9
HP:0002615 Hypotension 8
HP:0002666 Pheochromocytoma 7
HP:0030731 Carcinoma 7
HP:0000822 Hypertension 4
HP:0000969 Edema 4
HP:0001824 Weight loss 4
HP:0000952 Jaundice 3
HP:0001909 Leukemia 3
HP:0001943 Hypoglycemia 3
HP:0002018 Nausea 3
HP:0002019 Constipation 3
HP:0030828 Wheezing 3
HP:0000718 Aggressive behavior 2
HP:0000819 Diabetes mellitus 2
HP:0000980 Pallor 2
HP:0001396 Cholestasis 2
HP:0001649 Tachycardia 2
HP:0001962 Palpitations 2
HP:0002013 Vomiting 2
HP:0002094 Dyspnea 2
HP:0002099 Asthma 2
HP:0002835 Aspiration 2
HP:0004395 Malnutrition 2
HP:0005180 Tricuspid regurgitation 2
HP:0005208 Secretory diarrhea 2
HP:0012393 Allergy 2
HP:0025637 Vasospasm 2
HP:0032404 Testicular mass 2
HP:0100665 Angioedema 2
HP:0000023 Inguinal hernia 1
HP:0000029 Testicular atrophy 1
HP:0000282 Facial edema 1
HP:0000709 Psychosis 1
HP:0000821 Hypothyroidism 1
HP:0000825 Hyperinsulinemic hypoglycemia 1
HP:0000836 Hyperthyroidism 1
HP:0001025 Urticaria 1
HP:0001041 Facial erythema 1
HP:0001051 Seborrheic dermatitis 1
HP:0001254 Lethargy 1
HP:0001279 Syncope 1
HP:0001409 Portal hypertension 1
HP:0001541 Ascites 1
HP:0001635 Congestive heart failure 1
HP:0001694 Right-to-left shunt 1
HP:0001708 Right ventricular failure 1
HP:0001903 Anemia 1
HP:0001919 Acute kidney injury 1
HP:0001942 Metabolic acidosis 1
HP:0001945 Fever 1
HP:0002015 Dysphagia 1
HP:0002024 Malabsorption 1
HP:0002076 Migraine 1
HP:0002110 Bronchiectasis 1
HP:0002144 Tethered cord 1
HP:0002315 Headache 1
HP:0002360 Sleep disturbance 1
HP:0002414 Spina bifida 1
HP:0002563 Constrictive pericarditis 1
HP:0002576 Intussusception 1
HP:0002583 Colitis 1
HP:0002595 Ileus 1
HP:0002716 Lymphadenopathy 1
HP:0002861 Melanoma 1
HP:0003072 Hypercalcemia 1
HP:0003074 Hyperglycemia 1
HP:0003075 Hypoproteinemia 1
HP:0005240 Esophageal obstruction 1
HP:0005263 Gastritis 1
HP:0006688 Paroxysmal tachycardia 1
HP:0006722 Small intestine carcinoid 1
HP:0009792 Teratoma 1
HP:0010446 Tricuspid stenosis 1
HP:0010788 Testicular neoplasm 1
HP:0011134 Low-grade fever 1
HP:0012115 Hepatitis 1
HP:0012334 Extrahepatic cholestasis 1
HP:0012735 Cough 1
HP:0025406 Asthenia 1
HP:0025497 Coronary artery spasm 1
HP:0030405 Pancreatic endocrine tumor 1
HP:0030445 Pulmonary carcinoid tumor 1
HP:0030955 Alcoholism 1
HP:0031217 Hot flashes 1
HP:0031273 Shock 1
HP:0031500 Abdominal mass 1
HP:0031501 Pelvic mass 1
HP:0031944 Pleural thickening 1
HP:0032043 Odynophagia 1
HP:0100282 Acute colitis 1
HP:0100699 Scarring 1
HP:0100749 Chest pain 1
HP:0100758 Gangrene 1
HP:0410148 Idiopathic anaphylaxis 1


Causative gene(s) retrieved from Orphanet

    Total: 1

Gene Symbol Gene Name Entrez Gene ID
SDHD succinate dehydrogenase complex subunit D 6392