Opsoclonus-myoclonus syndrome

Opsoclonus myoclonus syndrome (OMS) is a rare neuroinflammatory disease of paraneoplastic, parainfectious or idiopathic origin, characterized by opsoclonus, myoclonus, ataxia, and behavioral and sleep disorders.

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Total: 138 (papers)

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Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (40.9%)	30596202	A case report of sphenoid sinusitis causing opsoclonus myoclonus syndrome. Turner H, Snelling J, Martinez-Devesa P. AME Case Rep. 2018;2:47. [ Show abstract ] [ Hide abstract ]
		Sinusitis



2 (35.3%)	30655046	Opsoclonus in a child with neuroborreliosis: Case report and review of the literature. Gibaud M, Pauvert O, Gueden S, Durigneux J, Van Bogaert P. Arch Pediatr. 2019;26(2):118-119. [ Show abstract ] [ Hide abstract ]
		Facial palsy
		CSF2

		Borrelia burgdorferi Child Females Homo sapiens Lyme Neuroborreliosis Ocular Motility Disorders
3 (26.3%)	21702171	[A case report on cervical neuroblastoma with ataxia]. Kanemura N, Nakano T, Hirano A, Amatsu H, Koshimo N, Uemura G, Aiba T. Nihon Jibiinkoka Gakkai Kaiho. 2011;114(5):505-10. [ Show abstract ] [ Hide abstract ]
		Ataxia Nasal obstruction


		Child, Preschool Females Head and Neck Neoplasms Homo sapiens Neuroblastoma Opsoclonus-Myoclonus Syndrome
4 (24.9%)	24987503 (4077209)	West nile virus encephalitis induced opsoclonus-myoclonus syndrome. Cooper CJ, Said S. Neurol Int. 2014;6(2):5359. [ Show abstract ] [ Hide abstract ]
		Edema Nuchal rigidity



5 (23.3%)	27296537	[Neurosurgical aspects of the treatment of neuroblastoma patients]. Ozerov SS, Samarin AE, Andreev ES, Tereshchenko GV, Kachanov DY, Shamanskaya TV, Varfolomeeva SR. Zh Vopr Neirokhir Im N N Burdenko. 2016;80(3):50-57. [ Show abstract ] [ Hide abstract ]
		Spinal cord compression Spinal deformities


		Decompression, Surgical Females Homo sapiens Infant Male Neuroblastoma Neurosurgical Procedures Peripheral Nervous System Neoplasms Postoperative Complications Spinal Cord Neoplasms
6 (17.5%)	25425177 (4255938)	Acute post-infectious cerebellar ataxia due to co-infection of human herpesvirus-6 and adenovirus mimicking myositis. Naselli A, Pala G, Cresta F, Finetti M, Biancheri R, Renna S. Ital J Pediatr. 2014;40:98. [ Show abstract ] [ Hide abstract ]
		Hydrocephalus Myositis


		Acute Disease Adenovirus Infections Adenoviruses Cerebellar Ataxia Child Coinfection Differential Diagnosis Homo sapiens Male Myositis Roseolovirus Infections
6 (17.5%)	19994603	[Small cell lung cancer complicated by opsoclonus myoclonus syndrome]. Iwata T, Yokomura I, Ohsugi S, Uesaka A, Sekiguchi K, Nishio A. Nihon Kokyuki Gakkai Zasshi. 2009;47(11):1046-50. [ Show abstract ] [ Hide abstract ]
		Ataxia Difficulty walking


		Carcinoma, Small Cell Homo sapiens Lung Neoplasms Male Middle Aged Opsoclonus-Myoclonus Syndrome
6 (17.5%)	15087109	Neuroblastoma: an unusual presentation with bilateral ptosis. Tatli B, Saribeyoglu ET, Aydinli N, Caliskan M, Anak S. Pediatr Neurol. 2004;30(4):284-6. [ Show abstract ] [ Hide abstract ]
		Ptosis Muscle weakness


		Biopsy Blepharoptosis Child, Preschool Diagnostic Imaging Differential Diagnosis Females Functional Laterality Homo sapiens Neuroblastoma Neurologic Examination Paraneoplastic Syndromes, Nervous System Spinal Neoplasms
9 (4.0%)	31139479	Paraneoplastic Opsoclonus Myoclonus in a Patient with Pancreatic Adenocarcinoma. Nwafor DC, Petrone AB, Collins JM, Adcock AK. Case Rep Neurol Med. 2019;2019:3601026. [ Show abstract ] [ Hide abstract ]
		Ataxia



9 (4.0%)	30937088	Opsoclonus Myoclonus Syndrome: A Rare Manifestation of Dengue Infection in a Child. Desai SD, Gandhi FR, Vaishnav A. J Pediatr Neurosci. 2018;13(4):455-458. [ Show abstract ] [ Hide abstract ]
		Seizure

Phenotype(s) retrieved from Orphanet

Total: 0

HPO ID	Term	Frequency

Phenotype(s) retrieved from case reports

Total: 36

HPO ID	Term	# of case reports
HP:0001336	Myoclonus	26
HP:0001251	Ataxia	24
HP:0010543	Opsoclonus	15
HP:0001298	Encephalopathy	8
HP:0030731	Carcinoma	5
HP:0000737	Irritability	3
HP:0002078	Truncal ataxia	3
HP:0030357	Small cell lung carcinoma	3
HP:0000819	Diabetes mellitus	2
HP:0001250	Seizures	2
HP:0001332	Dystonia	2
HP:0002014	Diarrhea	2
HP:0002090	Pneumonia	2
HP:0002133	Status epilepticus	2
HP:0002360	Sleep disturbance	2
HP:0002861	Melanoma	2
HP:0030358	Non-small cell lung carcinoma	2
HP:0031931	Ocular flutter	2
HP:0000488	Retinopathy	1
HP:0000734	Disinhibition	1
HP:0001289	Confusion	1
HP:0002267	Exaggerated startle response	1
HP:0002300	Mutism	1
HP:0002321	Vertigo	1
HP:0002521	Hypsarrhythmia	1
HP:0002860	Squamous cell carcinoma	1
HP:0004305	Involuntary movements	1
HP:0004376	Neuroblastic tumors	1
HP:0006725	Pancreatic adenocarcinoma	1
HP:0009792	Teratoma	1
HP:0010530	Palatal myoclonus	1
HP:0012115	Hepatitis	1
HP:0012315	Histiocytoma	1
HP:0025318	Ovarian carcinoma	1
HP:0032104	Saccadic oscillation	1
HP:0100543	Cognitive impairment	1

Causative gene(s) retrieved from Orphanet

Total: 0

Gene Symbol	Gene Name	Entrez Gene ID