Schistosomiasis

Schistosomiasis is an infectious disease caused by parasitic trematodes of the genus <i>Schistosoma</i> that colonize human blood vessels and release eggs that can cause granulomatous reactions leading to acute (swimmer's itch or acute schistosomiasis syndrome) or chronic disease. Depending on where the eggs lodge, manifestations of chronic schistosomiasis can include diarrhea, abdominal pain, loss of appetite, anemia (intestines), hepatosplenism, periportal fibrosis with portal hypertension (liver), urogenital inflammation and scarring, hematuria and dysuria (genitourinary system). Other patients may be asymptomatic.



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Total: 593 (papers)

   


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Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(50.9%)		 8259482
 [Hepatosplenic schistosomiasis: case report and clinical review].
Wirth HP, Casanova C, Meyenberger C, Hammer B, Ammann R, Blum HE.
Schweiz Med Wochenschr. 1993;123(42):1991-5.
Portal hypertension Splenomegaly Anemia
Adult Animals Feces Females Hepatitis C Homo sapiens Infant, Newborn Liver Diseases, Parasitic Liver Function Tests Pregnancy Pregnancy Complications, Parasitic Puerperal Disorders Schistosoma mansoni Schistosomiasis mansoni Spleen Splenic Diseases
2
(46.2%)		 22897170
 Intermittent fever, splenomegaly and eosinophilia in a recently resettled African refugee.
Mohd Abd Rahman M, Bryant P, Guppy D, Buttery J, Burgner D.
J Paediatr Child Health. 2012;48(10):939-41.
Hepatosplenomegaly Splenomegaly Eosinophilia Fever
Acute Disease Africa, Western Child Differential Diagnosis Eosinophilia Females Fever Homo sapiens Refugees Schistosomiasis Splenomegaly
3
(46.0%)		 23268737
(3574827)
 Culture-negative subacute bacterial endocarditis masquerades as granulomatosis with polyangiitis (Wegener's granulomatosis) involving both the kidney and lung.
Peng H, Chen WF, Wu C, Chen YR, Peng B, Paudel SD, Lou TQ.
BMC Nephrol. 2012;13:174.
Hepatosplenomegaly Fever Granulomatosis Palpable purpura
PRTN3
Bacterial Endocarditis Differential Diagnosis Homo sapiens Male Nephritis
4
(45.3%)		 29469316
 [Clinical features of imported schistosomiasis mansoni in Beijing City：a report of 6 cases].
Yang Z, Lei W, Xiao-Li L, Xiao-Jun T, Wei L, Yi-Jun A, Zhi-Qun Q, Jing-Jing L, Fei W, Min-Jun H.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2017;29(2):150-154.
Splenomegaly Eosinophilia Fever
Animals Beijing Helminth Antibodies Homo sapiens Schistosoma mansoni Schistosomiasis mansoni
5
(43.7%)		 11450835
 Elevated parathyroid hormone-related protein and hypercalcemia in two dogs with schistosomiasis.
Fradkin JM, Braniecki AM, Craig TM, Ramiro-Ibanez F, Rogers KS, Zoran DL.
J Am Anim Hosp Assoc. 2001;37(4):349-55.
Anemia Diarrhea Hypercalcemia
PTHLH
Animals Canis familiaris Differential Diagnosis Dog Diseases Females Hypercalcemia Male Proteins Schistosomiasis
6
(43.3%)		 11548081
 Parasitic procrastination: late-presenting ovale malaria and schistosomiasis.
Davis TM, Singh B, Sheridan G.
Med J Aust. 2001;175(3):146-8.
Jaundice Thrombocytopenia Fever
Adult Africa, Eastern Differential Diagnosis Females Homo sapiens Malaria Polymerase Chain Reaction Schistosomiasis
7
(40.0%)		 24939453
 Clinical management of advanced schistosomiasis: a case of portal vein thrombosis-induced splenomegaly requiring surgery.
Olveda DU, Olveda RM, Montes CJ, Chy D, Abellera JM 3rd, Cuajunco D, Lam AK, McManus DP, Li Y, Ross AG.
BMJ Case Rep. 2014;2014:.
Periportal fibrosis Splenomegaly Pancytopenia
Child Differential Diagnosis Homo sapiens Male Portal Hypertension Schistosomiasis Splenectomy Splenomegaly Venous Thrombosis
7
(40.0%)		 6726707
 Portal hypertension and hypersplenism in pregnancy secondary to chronic schistosomiasis. A case report.
Soto-Albors CE, Rayburn WF, Taylor L, Musselman M.
J Reprod Med. 1984;29(5):345-8.
Portal hypertension Splenomegaly Thrombocytopenia
Adult Females Homo sapiens Hypersplenism Portal Hypertension Pregnancy Pregnancy Complications, Cardiovascular Schistosoma mansoni Schistosomiasis
9
(38.8%)		 21566088
 Gastrointestinal basidiobolomycosis: an emerging fungal infection causing bowel perforation in a child.
El-Shabrawi MH, Kamal NM, Jouini R, Al-Harbi A, Voigt K, Al-Malki T.
J Med Microbiol. 2011;60(Pt 9):1395-402.
Eosinophilia Fever Vomiting Abdominal mass
Abdomen Antifungal Agents Biopsy Child Entomophthorales Histocytochemistry Homo sapiens Intestinal Perforation Male Mycoses Radiography, Abdominal Tomography, X-Ray Ultrasonography
10
(38.4%)		 1308952
 Serratia marcescens bacteremia associated with schistosomiasis mansoni.
Nishioka Sde A, Ferreira MS, Kleber M, Burgarelli N.
Rev Soc Bras Med Trop. 1992;25(3):191-3.
Jaundice Hepatosplenomegaly Fever
Adult Animals Bacteremia Chickenpox Combination Drug Therapy Cross Infection Feces Homo sapiens Male Schistosoma mansoni Schistosomiasis mansoni Serratia Infections Serratia marcescens
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 149

HPO ID Term # of case reports
HP:0030731 Carcinoma 31
HP:0001409 Portal hypertension 21
HP:0000790 Hematuria 20
HP:0032252 Granuloma 18
HP:0001880 Eosinophilia 15
HP:0001945 Fever 15
HP:0001394 Cirrhosis 11
HP:0012115 Hepatitis 11
HP:0000789 Infertility 8
HP:0000822 Hypertension 8
HP:0012486 Myelitis 8
HP:0031456 Ectopic pregnancy 7
HP:0002196 Myelopathy 6
HP:0002860 Squamous cell carcinoma 6
HP:0031035 Chronic infection 6
HP:0000100 Nephrotic syndrome 5
HP:0001250 Seizures 5
HP:0002721 Immunodeficiency 5
HP:0005214 Intestinal obstruction 5
HP:0010550 Paraplegia 5
HP:0012125 Prostate cancer 5
HP:0031864 Bacteremia 5
HP:0100523 Liver abscess 5
HP:0001744 Splenomegaly 4
HP:0001971 Hypersplenism 4
HP:0002040 Esophageal varix 4
HP:0002576 Intussusception 4
HP:0002862 Bladder carcinoma 4
HP:0030127 Endometriosis 4
HP:0100279 Ulcerative colitis 4
HP:0000099 Glomerulonephritis 3
HP:0001824 Weight loss 3
HP:0001873 Thrombocytopenia 3
HP:0002385 Paraparesis 3
HP:0002583 Colitis 3
HP:0000093 Proteinuria 2
HP:0000112 Nephropathy 2
HP:0000952 Jaundice 2
HP:0001082 Cholecystitis 2
HP:0001289 Confusion 2
HP:0001405 Periportal fibrosis 2
HP:0001433 Hepatosplenomegaly 2
HP:0002027 Abdominal pain 2
HP:0002090 Pneumonia 2
HP:0002664 Neoplasm 2
HP:0002835 Aspiration 2
HP:0002907 Microscopic hematuria 2
HP:0003072 Hypercalcemia 2
HP:0004937 Pulmonary artery aneurysm 2
HP:0006000 Ureteral obstruction 2
HP:0006559 Hepatic calcification 2
HP:0011854 Hemoperitoneum 2
HP:0012735 Cough 2
HP:0012740 Papilloma 2
HP:0025615 Abscess 2
HP:0030242 Portal vein thrombosis 2
HP:0032404 Testicular mass 2
HP:0200034 Papule 2
HP:0200123 Chronic hepatitis 2
HP:0500006 Urethritis 2
HP:0000016 Urinary retention 1
HP:0000020 Urinary incontinence 1
HP:0000023 Inguinal hernia 1
HP:0000027 Azoospermia 1
HP:0000126 Hydronephrosis 1
HP:0000131 Uterine leiomyoma 1
HP:0000132 Menorrhagia 1
HP:0000143 Rectovaginal fistula 1
HP:0000819 Diabetes mellitus 1
HP:0001025 Urticaria 1
HP:0001028 Hemangioma 1
HP:0001031 Subcutaneous lipoma 1
HP:0001287 Meningitis 1
HP:0001298 Encephalopathy 1
HP:0001395 Hepatic fibrosis 1
HP:0001541 Ascites 1
HP:0001586 Vesicovaginal fistula 1
HP:0001648 Cor pulmonale 1
HP:0001701 Pericarditis 1
HP:0001733 Pancreatitis 1
HP:0001891 Iron deficiency anemia 1
HP:0001903 Anemia 1
HP:0002013 Vomiting 1
HP:0002014 Diarrhea 1
HP:0002018 Nausea 1
HP:0002019 Constipation 1
HP:0002024 Malabsorption 1
HP:0002035 Rectal prolapse 1
HP:0002206 Pulmonary fibrosis 1
HP:0002243 Protein-losing enteropathy 1
HP:0002273 Tetraparesis 1
HP:0002580 Volvulus 1
HP:0002605 Hepatic necrosis 1
HP:0002955 Granulomatosis 1
HP:0003003 Colon cancer 1
HP:0003073 Hypoalbuminemia 1
HP:0003124 Hypercholesterolemia 1
HP:0003198 Myopathy 1
HP:0003308 Cervical subluxation 1
HP:0003401 Paresthesia 1
HP:0003418 Back pain 1
HP:0005200 Retroperitoneal fibrosis 1
HP:0005263 Gastritis 1
HP:0005374 Cellular immunodeficiency 1
HP:0006280 Chronic pancreatitis 1
HP:0006562 Viral hepatitis 1
HP:0008222 Female infertility 1
HP:0009792 Teratoma 1
HP:0010302 Spinal cord tumor 1
HP:0010447 Anal fistula 1
HP:0010788 Testicular neoplasm 1
HP:0011675 Arrhythmia 1
HP:0011736 Primary hyperaldosteronism 1
HP:0012461 Bacteriuria 1
HP:0012490 Panniculitis 1
HP:0012532 Chronic pain 1
HP:0012534 Dysesthesia 1
HP:0012587 Macroscopic hematuria 1
HP:0012597 Heavy proteinuria 1
HP:0012733 Macule 1
HP:0012819 Myocarditis 1
HP:0020108 Unusual parasitic infection 1
HP:0025203 Caput medusae 1
HP:0025343 Lupus anticoagulant 1
HP:0030155 Scrotal pain 1
HP:0030157 Flank pain 1
HP:0030248 Mesenteric venous thrombosis 1
HP:0030394 Fallopian tube carcinoma 1
HP:0030430 Neuroma 1
HP:0030828 Wheezing 1
HP:0031364 Ecchymosis 1
HP:0031369 Colon perforation 1
HP:0031500 Abdominal mass 1
HP:0032043 Odynophagia 1
HP:0032061 Hypereosinophilia 1
HP:0032118 Retinitis 1
HP:0040275 Adenocarcinoma of the large intestine 1
HP:0040276 Adenocarcinoma of the colon 1
HP:0100242 Sarcoma 1
HP:0100518 Dysuria 1
HP:0100561 Spinal cord lesion 1
HP:0100608 Metrorrhagia 1
HP:0100653 Optic neuritis 1
HP:0100699 Scarring 1
HP:0100727 Histiocytosis 1
HP:0100820 Glomerulopathy 1
HP:0200008 Intestinal polyposis 1
HP:0200026 Ocular pain 1
HP:0200119 Acute hepatitis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID