Nasolacrimal duct cyst

Nasolacrimal duct cyst describes a unilateral or bilateral congenital cyst of the nasolacrimal duct, which is almost always associated with dacryocystocele, presenting most commonly at birth or a few weeks of age (but rarely presenting in adulthood) as a benign, grayish blue mass in the inferomedial canthus or in the nasal cavity, that can cause epiphora, dacryocystitis (inflammation of the lacrimal sac) and nasal obstruction. It is more commonly reported in females.



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Total: 81 (papers)

   


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Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(57.8%)		 15300740
 The role of integrated imaging techniques for prenatal prediction of phenotype in two cases of facial anomalies.
Rustico MA, Lalatta F, Righini A, Spaccini L, Fabietti I, Nicolini U.
Prenat Diagn. 2004;24(7):508-12.
Micrognathia
Adult Congenital Abnormality External Ear Face Females Fluorescent in Situ Hybridization Homo sapiens Imaging, Three-Dimensional Infant, Newborn Lacrimal Apparatus Magnetic Resonance Imaging Male Micrognathism Nose Pregnancy Pregnancy Outcome Ultrasonography, Prenatal
2
(51.8%)		 30364810
(6198391)
 Endoscopic Management of Lacrimal System Dysgenesis and Dacryocystoceles in Fraser Syndrome: A Case Report and Literature Review.
Falls ME, Rabinowitz MP, Carrasco JR, Rabinowitz MR.
Allergy Rhinol (Providence). 2018;9:2152656718804905.
Cryptophthalmos Chronic sinusitis
3
(48.8%)		 16807158
 A new case of megalencephaly and perisylvian polymicrogyria with post-axial polydactyly and hydrocephalus: MPPH syndrome.
Colombani M, Chouchane M, Pitelet G, Morales L, Callier P, Pinard JP, Lion-Francois L, Thauvin-Robinet C, Mugneret F, Huet F, Guibaud L, Faivre L.
Eur J Med Genet. 2006;49(6):466-71.
Macrocephaly Polydactyly
Brain Females Homo sapiens Hydrocephalus Infant Magnetic Resonance Imaging Polydactyly Syndrome
4
(45.3%)		 24239218
 [Pediatric orbital cellulitis without sinusitis: report of four cases].
Promelle V, Bennai D, Drimbea A, Milazzo S, Bremond-Gignac D.
J Fr Ophtalmol. 2014;37(2):149-54.
Sinusitis Conjunctivitis
Blepharoptosis Child Differential Diagnosis Edema Exophthalmos Eye Infections, Bacterial Females Homo sapiens Infant Infant, Newborn Insect Bites and Stings Male Orbital Cellulitis Orbital Neoplasms Staphylococcal Infections
4
(45.3%)		 22784678
 Giant dacryocystomucopyocele in an adult: a review of lacrimal sac enlargements with clinical and histopathologic differential diagnoses.
Perry LJ, Jakobiec FA, Zakka FR, Rubin PA.
Surv Ophthalmol. 2012;57(5):474-85.
Sinusitis Dacryocystitis
Aged, 80 and over Bacteroidaceae Infections Biological Markers Dacryocystitis Dacryocystorhinostomy Differential Diagnosis Females Gram-Positive Bacterial Infections Homo sapiens Immunohistochemistry Lacrimal Duct Obstruction Mucocele Peptostreptococcus Prevotella X-Ray Computed Tomography
4
(45.3%)		 17084226
 Recurrent bilateral dacryocystoceles in Wegener's granulomatosis: a rhinologic perspective.
Westbrook BJ, Scurry WC Jr, Hudak DT, McGinn J, Stack BC Jr.
Am J Otolaryngol. 2006;27(6):409-12.
Dacryocystitis Recurrent sinusitis
Dacryocystitis Females Homo sapiens X-Ray Computed Tomography
7
(43.3%)		 26509540
 [Dacryocystitis in a three-week-old girl].
Uth CC, Voorde PT, Boljanovic S.
Ugeskr Laeger. 2015;177(44):V04150369.
Dacryocystitis Encephalocele
Anti-Bacterial Agents Dacryocystitis Females Homo sapiens Infant, Newborn
7
(43.3%)		 21276064
 Case report: Congenital dacryocystocele and dacryocystitis.
Fussell JN, Wilson T, Pride H.
Pediatr Dermatol. 2011;28(1):70-2.
Nasolacrimal duct obstruction Encephalocele
Anti-Bacterial Agents Dacryocystitis Dacryocystorhinostomy Differential Diagnosis Females Homo sapiens Infant, Newborn Lacrimal Apparatus Diseases Lacrimal Duct Obstruction Neoplastic Syndromes, Hereditary
7
(43.3%)		 10821033
 [Facial dysmorphism due to complicated congenital nasolacrimal duct obstruction].
van Kuijck MA, Verbeek AM, Klevering BJ, Semmekrot BA.
Ned Tijdschr Geneeskd. 2000;144(19):873-7.
Nasolacrimal duct obstruction Encephalocele
Congenital Abnormality Differential Diagnosis Face Females Homo sapiens Infant, Newborn Male Mucocele Respiratory Insufficiency
10
(40.2%)		 26724215
 [Congenital lacrimonasal duct cyst: Do not forget this radiological and clinical entity].
Braun JJ, Debry C, Donato L, Riehm S.
Arch Pediatr. 2016;23(2):192-6.
Nasal obstruction Meningoencephalocele
Cyst Females Homo sapiens Infant Infant, Newborn Lacrimal Apparatus Diseases Male
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 27

HPO ID Term # of case reports
HP:0000620 Dacryocystitis 14
HP:0000579 Nasolacrimal duct obstruction 11
HP:0002098 Respiratory distress 10
HP:0009926 Epiphora 7
HP:0001742 Nasal obstruction 6
HP:0001028 Hemangioma 5
HP:0002617 Dilatation 4
HP:0002643 Neonatal respiratory distress 4
HP:0100658 Cellulitis 4
HP:0002084 Encephalocele 3
HP:0025247 Dermoid cyst 3
HP:0009792 Teratoma 2
HP:0010566 Hamartoma 2
HP:0000316 Hypertelorism 1
HP:0000347 Micrognathia 1
HP:0000483 Astigmatism 1
HP:0000522 Alacrima 1
HP:0000563 Keratoconus 1
HP:0000961 Cyanosis 1
HP:0002093 Respiratory insufficiency 1
HP:0002664 Neoplasm 1
HP:0002835 Aspiration 1
HP:0006888 Meningoencephalocele 1
HP:0010605 Chalazion 1
HP:0012803 Anisometropia 1
HP:0100242 Sarcoma 1
HP:0200040 Epidermoid cyst 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID