Indeterminate cell histiocytosis

A rare neoplastic disease characterized by multiple, and on occasion single, asymptomatic, smooth, red-brown papulonodules located on the face, neck, trunk and/or extremities which present a nonepidermotrophic histiocytic infiltrate with immunohistochemical features of both Langerhans and non-Langerhans cells (i.e. immunopositive for S100 protein and CD1a in the absence of Birbeck granules and langerin expression).



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Narrow down the case reports



Total: 32 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(23.3%)		 28755918
 Indeterminate Dendritic Cell Tumor in Thoracic Spine: A Case Report.
Tan SK, Chieng LO, Madhavan K, Rosenberg A, Cote I.
World Neurosurg. 2017;108:543-547.
Lymphadenopathy Back pain
CD163 CD1A CD207 CD68 PTPRC S100A1
Dendritic Cells Differential Diagnosis Diskectomy Hematologic Neoplasms Homo sapiens Male Middle Aged Spinal Neoplasms
2
(4.0%)		 30320463
 Indeterminate dendritic cell neoplasm accompanied by eosinophilic pneumonia successfully treated by systemic steroid therapy: Report of the first case with muscular and parotid involvement and review of published work.
Kiyohara T, Nakamaru S, Miyamoto M, Shijimaya T, Nagano N, Makimura K, Takama H, Akiyama M, Tanimura H.
J Dermatol. 2018;45(12):1444-1447.
Eosinophilia
CD1A CD207 CD68 S100A1
Adult Biopsy Histiocytosis, Langerhans-Cell Homo sapiens Lung Male Parotid Gland Pulmonary Eosinophilia Skin Neoplasms
2
(4.0%)		 29877893
 Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review.
Davick JJ, Kim J, Wick MR, Gru AA.
Am J Dermatopathol. 2018;40(10):736-748.
Neoplasm
CD1A CD207 ETV3 NCOA2
Biopsy Cell Proliferation Child Dendritic Cells Differential Diagnosis Females Genetic Markers Genetic Predisposition to Disease Histiocytosis, Non-Langerhans-Cell Homo sapiens Immunohistochemistry Middle Aged Phenotype Predictive Value of Tests Proto-Oncogene Proteins c-ets Skin
2
(4.0%)		 29070620
 Special variant of histiocytosis.
Quint KD, Cleven AH, Vermeer MH.
BMJ Case Rep. 2017;2017:.
Histiocytosis
ETV3 NCOA2
Differential Diagnosis Histiocytosis Homo sapiens Male Proto-Oncogene Proteins c-ets Rare Diseases Ultraviolet Therapy
2
(4.0%)		 28966519
(5597656)
 Aggressive Indeterminate Dendritic Cell Tumor Mimicking Scalp Angiosarcoma.
Li Y, Wang TT, Zhang ZH, Wang L.
Ann Dermatol. 2017;29(5):614-617.
Lymphadenopathy
2
(4.0%)		 28940363
 Tick bite mimicking indeterminate cell histiocytosis.
Stringer T, Ghazi E, Alvarez Del Manzano G, Beasley J, Brinster N, Oza VS.
Pediatr Dermatol. 2017;34(6):e347-e348.
Granuloma
Animals Anti-Inflammatory Agents Child, Preschool Differential Diagnosis Exanthema Histiocytes Histiocytosis Homo sapiens Injections, Intralesional Male Skin Ticks
2
(4.0%)		 28885734
 Chronic myelomonocytic leukemia masquerading as cutaneous indeterminate dendritic cell tumor: Expanding the spectrum of skin lesions in chronic myelomonocytic leukemia.
Loghavi S, Curry JL, Garcia-Manero G, Patel KP, Xu J, Khoury JD, Torres-Cabala CA, Nagarajan P, Aung PP, Gibson BR, Goodwin BP, Kelly BC, Korivi BR, Medeiros LJ, Prieto VG, Kantarjian HM, Bueso-Ramos CE, Tetzlaff MT.
J Cutan Pathol. 2017;44(12):1075-1079.
Splenomegaly
CD1A KRAS
p|SUB|G|12|R;RS#:121913530
Biopsy Bone Marrow Dendritic Cells Disease Progression Homo sapiens Leukemia, Myelomonocytic, Chronic Lymphoma, Non-Hodgkin Male Mutation Positron-Emission Tomography Proto-Oncogene Proteins p21(ras) Skin Splenomegaly
2
(4.0%)		 28880462
 Indeterminate dendritic cell neoplasm of the skin: A 2-case report and review of the literature.
Horna P, Shao H, Idrees A, Glass LF, Torres-Cabala CA.
J Cutan Pathol. 2017;44(11):958-963.
Neoplasm
BRAF CD1A CD207
p|SUB|V|600|E;RS#:113488022
Homo sapiens Male Middle Aged Skin Neoplasms
2
(4.0%)		 28825606
 Cutaneous Indeterminate Cell Histiocytosis of Donor Origin After Allogeneic Hematopoietic Stem-Cell Transplantation.
Santos-Briz A, Roman C, Corral R, de Dios A, Vazquez L, Ludena MD.
Am J Dermatopathol. 2017;39(9):696-699.
Neoplasm
Histiocytosis Homo sapiens Male Middle Aged
2
(4.0%)		 28633156
 Generalized Indeterminate Cell Histiocytosis Presenting as Eroded Papules and Crusts.
Li Y, Bai HX, Su C, Zhang G.
Am J Dermatopathol. 2017;39(7):542-544.
Ascites
Females Histiocytosis Homo sapiens Lung Middle Aged Skin
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 6

HPO ID Term # of case reports
HP:0100727 Histiocytosis 5
HP:0002664 Neoplasm 2
HP:0002090 Pneumonia 1
HP:0012500 Verrucous papule 1
HP:0100242 Sarcoma 1
HP:0200034 Papule 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID