Fetal minoxidil syndrome is characterized by a group of symptoms that may be observed in a fetus or newborn when the mother has taken minoxidil during pregnancy. Minoxidil is used in the treatment of malignant renal hypertension and as a topical solution to induce scalp hair growth. Hypertrichosis that gradually diminishes during the first six postnatal months has been reported. Additional reported features include cardiac (congenital great vessel transposition and pulmonary valve stenosis), neurodevelopmental (caudal regression sequence) (see these terms), gastrointestinal, renal, and limb malformations. Conclusive studies are however not available.
Matched Phenotype
Gene
Mutation
MeSH
Rank
(Similarity) |
PMID
(PMCID) |
Phenotype(s) retrieved from Orphanet
Total: 8
| HPO ID |
Term |
Frequency |
| HP:0000028 |
Cryptorchidism |
Very frequent (99-80%) |
| HP:0000347 |
Micrognathia |
Very frequent (99-80%) |
| HP:0000368 |
Low-set, posteriorly rotated ears |
Very frequent (99-80%) |
| HP:0001537 |
Umbilical hernia |
Very frequent (99-80%) |
| HP:0001629 |
Ventricular septal defect |
Very frequent (99-80%) |
| HP:0002230 |
Generalized hirsutism |
Very frequent (99-80%) |
| HP:0004209 |
Clinodactyly of the 5th finger |
Very frequent (99-80%) |
| HP:0005280 |
Depressed nasal bridge |
Very frequent (99-80%) |
Phenotype(s) retrieved from case reports
Total: 0
| HPO ID |
Term |
# of case reports |
Causative gene(s) retrieved from Orphanet
Total: 0
| Gene Symbol |
Gene Name |
Entrez Gene ID |
