Drug-induced lupus erythematosus

A rare, systemic disease with skin involvement characterized by the onset of idiopathic lupus erythematosus-like signs and symptoms resulting from continuous drug intake (>1 month), which resolve when treatment is discontinued, in persons with no history of autoimmune disease. Manifestations are variable and may be systemic (e.g. arthralgia, myalgia, fever, fatigue, serositis, pleuritis, pericarditis), subacute cutaneous (incl. photosensitive, non-scarring, annular, polycyclic or papulosquamous lesions, malar erythema, vasculitis, bullous lesions, erythema multiforme-like changes), and/or chronic cutaneous (typically discoid lesions in sun-exposed areas). Procainamide and hydrazaline are the drugs most frequently implicated.



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Narrow down the case reports



Total: 36 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(27.8%)		 22530328
 Sweet syndrome associated with hydralazine-induced lupus erythematosus.
Cartee TV, Chen SC.
Cutis. 2012;89(3):121-4.
Stomatitis
Antibodies, Antinuclear Antihypertensive Agents Differential Diagnosis Homo sapiens Lupus Erythematosus, Systemic Male Middle Aged Portal Hypertension Sweet Syndrome
1
(27.8%)		 20700874
 [Persistent neutropenia].
Burki S, Oestmann A, Vogel D, Oertle S.
Praxis (Bern 1994). 2010;99(16):981-4.
Neutropenia Sialadenitis
Adrenal Cortex Hormones Anti-Bacterial Agents Anti-Inflammatory Agents, Non-Steroidal Differential Diagnosis Females Histones Homo sapiens Lupus Erythematosus, Systemic Neutropenia Sialadenitis
3
(23.3%)		 14658003
 Drug-induced lupus erythematosus secondary to nafcillin: the first reported case.
Blazes DL, Martin GJ.
Rheumatol Int. 2004;24(4):242-3.
Low back pain
Anti-Bacterial Agents Homo sapiens Lupus Erythematosus, Systemic Male Middle Aged Staphylococcal Skin Infections Staphylococcus aureus
4
(21.2%)		 22350045
 Wilson's disease treated with penicillamine and lupus erythematosus: related or distinct entities?
Dell'era L, Boati E, Nebbia G, Corona F.
Minerva Pediatr. 2012;64(1):55-7.
Proteinuria Arthritis
Females Hepatolenticular Degeneration Homo sapiens Lupus Erythematosus, Systemic
4
(21.2%)		 21323997
 Systemic lupus erythematosus induced by interferon beta1 therapy in a patient with multiple sclerosis.
Bahri DM, Khiari H, Essouri A, Laadhar L, Zaraa I, Mrabet A, Meddeb N, Sellami S.
Fundam Clin Pharmacol. 2012;26(2):210-1.
Myalgia Synovitis
Adult Females Glucocorticoids Homo sapiens Immunologic Adjuvants Lupus Erythematosus, Systemic Multiple Sclerosis Synovitis
4
(21.2%)		 19229504
 [Drug-induced lupus erythematosus tumidus during treatment with adalimumab].
Sohl S, Renner R, Winter U, Bodendorf M, Paasch U, Simon JC, Treudler R.
Hautarzt. 2009;60(10):826-9.
Rheumatoid arthritis
TNF
Adult Anti-Inflammatory Agents Antibodies, Monoclonal, Humanized Drug Eruptions Females Homo sapiens Lupus Erythematosus, Cutaneous Monoclonal Antibodies
4
(21.2%)		 11897931
 Isoniazid-induced lupus erythematosus presenting with cardiac tamponade.
Siddiqui MA, Khan IA.
Am J Ther. 2002;9(2):163-5.
Arthritis
Antitubercular Agents Cardiac Tamponade Homo sapiens Lupus Erythematosus, Systemic Male Tuberculosis, Pulmonary
4
(21.2%)		 1407211
 [Disseminated lupus erythematosus induced by carbamazepine (Tegretol)].
Boon DM, van Parys JA, Swaak AJ.
Ned Tijdschr Geneeskd. 1992;136(42):2085-7.
Arthritis
Adult Antibodies, Antinuclear Anticonvulsants Epilepsy Homo sapiens Lupus Erythematosus, Systemic Male
9
(4.0%)		 30613100
 When Chest Pain Reveals More: A Case of Hydrochlorothiazide-Induced Systemic Lupus Erythematosus.
Sosenko T, Pasula S, Brahmamdam R, Girnita D.
Am J Case Rep. 2019;20:26-30.
Hypertension
Chest Pain Diuretics Dyspnea Homo sapiens Lupus Erythematosus, Systemic Male Middle Aged
9
(4.0%)		 29782299
 Drug-induced Subacute Cutaneous Lupus Erythematosus Caused by a Topical Beta Blocker - Timolol.
Bilewicz-Stebel M, Miziolek B, Bergler-Czop B, Stankowska A.
Acta Dermatovenerol Croat. 2018;26(1):44-47.
Glaucoma
Administration, Topical Adrenergic beta-Antagonists Females Follow-Up Studies Glaucoma Health Risk Assessment Homo sapiens Lupus Erythematosus, Cutaneous Severity of Illness Index Withholding Treatment
        

Phenotype(s) retrieved from Orphanet

    Total: 23

HPO ID Term Frequency
HP:0000790 Hematuria Very frequent (99-80%)
HP:0000967 Petechiae Very frequent (99-80%)
HP:0001698 Pericardial effusion Very frequent (99-80%)
HP:0001701 Pericarditis Very frequent (99-80%)
HP:0001873 Thrombocytopenia Very frequent (99-80%)
HP:0001903 Anemia Very frequent (99-80%)
HP:0002094 Dyspnea Very frequent (99-80%)
HP:0002829 Arthralgia Very frequent (99-80%)
HP:0003138 Increased blood urea nitrogen Very frequent (99-80%)
HP:0003236 Elevated serum creatine kinase Very frequent (99-80%)
HP:0003326 Myalgia Very frequent (99-80%)
HP:0003493 Antinuclear antibody positivity Very frequent (99-80%)
HP:0003565 Elevated erythrocyte sedimentation rate Very frequent (99-80%)
HP:0005184 Prolonged QTc interval Very frequent (99-80%)
HP:0005421 Decreased serum complement C3 Very frequent (99-80%)
HP:0011227 Elevated C-reactive protein level Very frequent (99-80%)
HP:0025300 Malar rash Very frequent (99-80%)
HP:0025343 Lupus anticoagulant Very frequent (99-80%)
HP:0030057 Autoimmune antibody positivity Very frequent (99-80%)
HP:0045042 Decreased serum complement C4 Very frequent (99-80%)
HP:0001945 Fever Frequent (79-30%)
HP:0045073 Serositis Frequent (79-30%)
HP:0025142 Constitutional symptom Occasional (29-5%)


Phenotype(s) retrieved from case reports

    Total: 10

HPO ID Term # of case reports
HP:0000822 Hypertension 1
HP:0001698 Pericardial effusion 1
HP:0001701 Pericarditis 1
HP:0001873 Thrombocytopenia 1
HP:0002202 Pleural effusion 1
HP:0002721 Immunodeficiency 1
HP:0010783 Erythema 1
HP:0012051 Reactive hypoglycemia 1
HP:0100279 Ulcerative colitis 1
HP:0100584 Endocarditis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID