Cronkhite-Canada syndrome

Cronkhite-Canada syndrome (CCS) is a rare gastrointestinal (GI) polyposis syndrome characterized by the association of non-hereditary GI polyposis with the cutaneous triad of alopecia, nail changes and hyperpigmentation.



Input patient's signs and symptoms


Narrow down the case reports



Total: 102 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(53.2%)		 3794950
 Juvenile gastrointestinal polyposis or the infantile Cronkhite-Canada syndrome.
Scharf GM, Becker JH, Laage NJ.
J Pediatr Surg. 1986;21(11):953-4.
Macrocephaly Clubbing of fingers
Homo sapiens Infant Intestinal Polyps Male Neoplasms, Multiple Primary Stomach Neoplasms Syndrome
1
(53.2%)		 1329940
 Infantile Cronkhite-Canada syndrome?--Case report.
Kucukaydin M, Patiroglu TE, Okur H, Icer M.
Eur J Pediatr Surg. 1992;2(5):295-7.
Macrocephaly Clubbing of fingers
Adenomatous Polyposis Coli Child, Preschool Females Homo sapiens Intestinal Polyps
3
(23.3%)		 20955587
(2972238)
 Cronkhite-Canada syndrome associated with rib fractures: a case report.
Yuan B, Jin X, Zhu R, Zhang X, Liu J, Wan H, Lu H, Shen Y, Wang F.
BMC Gastroenterol. 2010;10:121.
Weight loss Multiple rib fractures
Endoscopy, Gastrointestinal Follow-Up Studies Homo sapiens Intestinal Polyposis Male Middle Aged Osteoporotic Fractures Radiography, Thoracic Rib Fractures
4
(21.2%)		 29901325
 Anemia and Neutropenia in Copper-Deficient Patients: A Report of Two Cases and Literature Review.
Hantaweepant C, Chinthammitr Y, Siritanaratkul N.
J Med Assoc Thai. 2016;99(6):732-6.
Arthritis
Adult Anemia Deficiency Diseases Homo sapiens Intestinal Polyposis Male Middle Aged Neutropenia Short Bowel Syndrome
4
(21.2%)		 28178153
(5313010)
 Case report-malignant transformation in Cronkhite-Canada syndrome polyp.
Zong Y, Zhao H, Yu L, Ji M, Wu Y, Zhang S.
Medicine (Baltimore). 2017;96(6):e6051.
Weight loss Bone fracture
Colonic Polyps Homo sapiens Intestinal Polyposis Male Middle Aged Neoplastic Cell Transformation
4
(21.2%)		 25518819
 Cronkhite-Canada syndrome showing elevated levels of antinuclear and anticentromere antibody.
Ota S, Kasahara A, Tada S, Tanaka T, Umena S, Fukatsu H, Noguchi T, Matsumura T.
Clin J Gastroenterol. 2015;8(1):29-34.
Arthritis
Anti-Inflammatory Agents Antibodies, Antinuclear Arthritis Females Graves Disease Homo sapiens Intestinal Polyposis Middle Aged
4
(21.2%)		 4011892
 Erosive arthritis in Cronkhite-Canada syndrome.
Sanders KM, Resnik CS, Owen DS.
Radiology. 1985;156(2):309-10.
Arthritis
Arthritis Colonic Neoplasms Homo sapiens Intestinal Polyps Male Stomach Neoplasms Syndrome Synovitis
8
(17.5%)		 433675
 A patient with Cronkhite-Canada syndrome, myxedema and muscle atrophy.
Storset O, Todnem K, Waldum HL, Burhol PG, Kearney MS.
Acta Med Scand. 1979;205(4):343-6.
Primary hypothyroidism Myopathy
Females Homo sapiens Intestinal Polyps Muscular Atrophy Myxedema Pigmentation Disorders Syndrome
9
(4.0%)		 30813906
 Case report of patient with aCronkhite-Canada syndrome: sustained remission after treatment with corticosteroids and mesalazine.
Schulte S, Kutting F, Mertens J, Kaufmann T, Drebber U, Nierhoff D, Tox U, Steffen HM.
BMC Gastroenterol. 2019;19(1):36.
Weight loss
Alopecia Anti-Inflammatory Agents, Non-Steroidal Diarrhea Differential Diagnosis Drug Administration Schedule Dysgeusia Glucocorticoids Homo sapiens Intestinal Polyposis Male Malnutrition Nail Diseases Remission Induction
9
(4.0%)		 30643792
 A Case Report of Cronkhite-Canada Syndrome Complicated by Membranous Nephropathy.
Firth C, Harris LA, Smith ML, Thomas LF.
Case Rep Nephrol Dial. 2018;8(3):261-267.
Proteinuria
        

Phenotype(s) retrieved from Orphanet

    Total: 33

HPO ID Term Frequency
HP:0001000 Abnormality of skin pigmentation Very frequent (99-80%)
HP:0001231 Abnormal fingernail morphology Very frequent (99-80%)
HP:0001596 Alopecia Very frequent (99-80%)
HP:0001800 Hypoplastic toenails Very frequent (99-80%)
HP:0001810 Dystrophic toenail Very frequent (99-80%)
HP:0002014 Diarrhea Very frequent (99-80%)
HP:0002024 Malabsorption Very frequent (99-80%)
HP:0002232 Patchy alopecia Very frequent (99-80%)
HP:0004390 Hamartomatous polyposis Very frequent (99-80%)
HP:0007440 Generalized hyperpigmentation Very frequent (99-80%)
HP:0008391 Dystrophic fingernails Very frequent (99-80%)
HP:0200008 Intestinal polyposis Very frequent (99-80%)
HP:0001004 Lymphedema Frequent (79-30%)
HP:0001903 Anemia Frequent (79-30%)
HP:0002027 Abdominal pain Frequent (79-30%)
HP:0002039 Anorexia Frequent (79-30%)
HP:0002231 Sparse body hair Frequent (79-30%)
HP:0002597 Abnormality of the vasculature Frequent (79-30%)
HP:0004326 Cachexia Frequent (79-30%)
HP:0012378 Fatigue Frequent (79-30%)
HP:0100840 Aplasia/Hypoplasia of the eyebrow Frequent (79-30%)
HP:0000221 Furrowed tongue Occasional (29-5%)
HP:0000224 Decreased taste sensation Occasional (29-5%)
HP:0000256 Macrocephaly Occasional (29-5%)
HP:0000518 Cataract Occasional (29-5%)
HP:0001182 Tapered finger Occasional (29-5%)
HP:0001250 Seizures Occasional (29-5%)
HP:0001744 Splenomegaly Occasional (29-5%)
HP:0002240 Hepatomegaly Occasional (29-5%)
HP:0002664 Neoplasm Occasional (29-5%)
HP:0002672 Gastrointestinal carcinoma Occasional (29-5%)
HP:0003003 Colon cancer Occasional (29-5%)
HP:0012126 Stomach cancer Occasional (29-5%)


Phenotype(s) retrieved from case reports

    Total: 32

HPO ID Term # of case reports
HP:0003003 Colon cancer 8
HP:0030731 Carcinoma 7
HP:0008404 Nail dystrophy 5
HP:0001824 Weight loss 4
HP:0002014 Diarrhea 4
HP:0002243 Protein-losing enteropathy 3
HP:0004390 Hamartomatous polyposis 3
HP:0000821 Hypothyroidism 2
HP:0002028 Chronic diarrhea 2
HP:0002617 Dilatation 2
HP:0004395 Malnutrition 2
HP:0000518 Cataract 1
HP:0000622 Blurred vision 1
HP:0001369 Arthritis 1
HP:0001548 Overgrowth 1
HP:0001806 Onycholysis 1
HP:0001875 Neutropenia 1
HP:0001903 Anemia 1
HP:0001972 Macrocytic anemia 1
HP:0002024 Malabsorption 1
HP:0002027 Abdominal pain 1
HP:0002576 Intussusception 1
HP:0003073 Hypoalbuminemia 1
HP:0004394 Multiple gastric polyps 1
HP:0005521 Disseminated intravascular coagulation 1
HP:0007663 Reduced visual acuity 1
HP:0012578 Membranous nephropathy 1
HP:0012733 Macule 1
HP:0025088 Onychomadesis 1
HP:0100279 Ulcerative colitis 1
HP:0100753 Schizophrenia 1
HP:0200008 Intestinal polyposis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID