Manganese poisoning




Input patient's signs and symptoms


Narrow down the case reports



Total: 50 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(21.2%)		 28074748
 Possible Parkinson's Disease Induced by Chronic Manganese Supplement Ingestion.
Schuh MJ.
Consult Pharm. 2016;31(12):698-703.
Osteoporosis
Adult Cat's Claw Dietary Supplements Dose-Response Relationship, Drug Eucalyptus Females Homo sapiens Medication Therapy Management Plant Preparations Secondary Parkinson Disease
2
(4.0%)		 29887684
 B/L Basal Ganglia Lesions in a Child Leading to a Diagnosis of Glucose-6-Phosphate Dehydrogenase Deficiency.
Prabhakar N, Ahuja CK, Khandelwal N.
Ann Neurosci. 2018;25(1):50-52.
Hypoglycemia
ABO G6PD
2
(4.0%)		 29685658
 Novel founder intronic variant in SLC39A14 in two families causing Manganism and potential treatment strategies.
Rodan LH, Hauptman M, D'Gama AM, Qualls AE, Cao S, Tuschl K, Al-Jasmi F, Hertecant J, Hayflick SJ, Wessling-Resnick M, Yang ET, Berry GT, Gropman A, Woolf AD, Agrawal PB.
Mol Genet Metab. 2018;124(2):161-167.
Parkinsonism
SLC39A14
Cation Transport Proteins Chelating Agents Child Child, Preschool Dystonia Disorders Females Homo sapiens Male Metal Metabolism, Inborn Errors Mutation Parkinsonian Disorders
2
(4.0%)		 27163837
 Massive intravenous manganese overdose due to compounding error: minimal role for hemodialysis.
Hines EQ, Soomro I, Howland MA, Hoffman RS, Smith SW.
Clin Toxicol (Phila). 2016;54(6):523-5.
Parkinsonism
Chelating Agents Dose-Response Relationship, Drug Drug Overdose Females Homo sapiens Magnetic Resonance Imaging Manganese Poisoning Middle Aged Neurotoxicity Syndromes Renal Dialysis
2
(4.0%)		 26256070
 Delayed cognitive and psychiatric symptoms following methyl iodide and manganese poisoning: Potential for misdiagnosis.
Mackenzie Ross S.
Cortex. 2016;74:427-39.
Personality changes
Cognition Disorders Diagnostic Errors Homo sapiens Hydrocarbons, Iodinated Male Manganese Poisoning Middle Aged Neuropsychological Tests Occupational Exposure Secondary Parkinson Disease Time Factors
2
(4.0%)		 25835774
 Acute hyperkinetic syndrome due to ephedrone abuse.
Dolgan A, Budrewicz S, Koszewicz M, Bladowska J, Slotwinski K, Zagrajek M, Koziorowska-Gawron E, Podemski R.
J Addict Med. 2015;9(3):244-5.
Gait disturbance
Acute Disease Adult Brain Homo sapiens Hyperkinesia Magnetic Resonance Imaging Male Neuroimaging Propiophenones Substance-Related Disorders
2
(4.0%)		 25080444
 Acute enteral manganese intoxication with hepatic failure due to ingestion of a joint supplement overdose.
Borchers A, Epstein SE, Gindiciosi B, Cartoceti A, Puschner B.
J Vet Diagn Invest. 2014;26(5):658-63.
Ataxia
Animals Canis familiaris Chemical and Drug Induced Liver Injury Dietary Supplements Dog Diseases Drug Overdose Females Kidney Liver Poisoning
2
(4.0%)		 24963359
(4067420)
 MRI brain findings in ephedrone encephalopathy associated with manganese abuse: Single-center perspective.
Poniatowska R, Lusawa M, Skierczynska A, Makowicz G, Habrat B, Sienkiewicz-Jarosz H.
Pol J Radiol. 2014;79:150-5.
Encephalopathy
2
(4.0%)		 24746291
 Inherited manganism: the "cock-walk" gait and typical neuroimaging features.
Avelino MA, Fusao EF, Pedroso JL, Arita JH, Ribeiro RT, Pinho RS, Tuschl K, Barsottini OG, Masruha MR.
J Neurol Sci. 2014;341(1-2):150-2.
Dystonia
Cation Transport Proteins Child Females Gait Disorders, Neurologic Homo sapiens Manganese Poisoning Neuroimaging
2
(4.0%)		 23609215
 Manganese-induced Parkinsonism among ephedrone users and drug policy in Poland.
Fudalej S, Kolodziejczyk I, Gajda T, Majkowska-Zwolinska B, Wojnar M.
J Addict Med. 2013;7(4):302-3.
Parkinsonism
Adult Homo sapiens Illicit Drugs Male Parkinsonian Disorders Propiophenones Substance-Related Disorders
        

Phenotype(s) retrieved from Orphanet

    Total: 30

HPO ID Term Frequency
HP:0000712 Emotional lability Very frequent (99-80%)
HP:0001276 Hypertonia Very frequent (99-80%)
HP:0001288 Gait disturbance Very frequent (99-80%)
HP:0001332 Dystonia Very frequent (99-80%)
HP:0002067 Bradykinesia Very frequent (99-80%)
HP:0002071 Abnormality of extrapyramidal motor function Very frequent (99-80%)
HP:0002172 Postural instability Very frequent (99-80%)
HP:0002174 Postural tremor Very frequent (99-80%)
HP:0002315 Headache Very frequent (99-80%)
HP:0002354 Memory impairment Very frequent (99-80%)
HP:0002396 Cogwheel rigidity Very frequent (99-80%)
HP:0002453 Abnormal globus pallidus morphology Very frequent (99-80%)
HP:0003287 Abnormality of mitochondrial metabolism Very frequent (99-80%)
HP:0006979 Sleep-wake cycle disturbance Very frequent (99-80%)
HP:0025464 Increased reactive oxygen species production Very frequent (99-80%)
HP:0000505 Visual impairment Frequent (79-30%)
HP:0000718 Aggressive behavior Frequent (79-30%)
HP:0000722 Obsessive-compulsive behavior Frequent (79-30%)
HP:0000746 Delusions Frequent (79-30%)
HP:0000748 Inappropriate laughter Frequent (79-30%)
HP:0000802 Impotence Frequent (79-30%)
HP:0001289 Confusion Frequent (79-30%)
HP:0002304 Akinesia Frequent (79-30%)
HP:0030018 Decreased female libido Frequent (79-30%)
HP:0040306 Decreased male libido Frequent (79-30%)
HP:0000716 Depressivity Occasional (29-5%)
HP:0000737 Irritability Occasional (29-5%)
HP:0000738 Hallucinations Occasional (29-5%)
HP:0030214 Hypersexuality Occasional (29-5%)
HP:0031466 Impairment in personality functioning Occasional (29-5%)


Phenotype(s) retrieved from case reports

    Total: 18

HPO ID Term # of case reports
HP:0001300 Parkinsonism 9
HP:0001332 Dystonia 2
HP:0001337 Tremor 2
HP:0002072 Chorea 2
HP:0031848 Cock-walk gait 2
HP:0000726 Dementia 1
HP:0000737 Irritability 1
HP:0001250 Seizures 1
HP:0001298 Encephalopathy 1
HP:0001394 Cirrhosis 1
HP:0001399 Hepatic failure 1
HP:0001943 Hypoglycemia 1
HP:0002174 Postural tremor 1
HP:0002315 Headache 1
HP:0002360 Sleep disturbance 1
HP:0004305 Involuntary movements 1
HP:0012378 Fatigue 1
HP:0100660 Dyskinesia 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID