Eosinophilic fasciitis

Eosinophilic fasciitis is a rare connective tissue disease that is characterized by inflammation and thickening of the fascia, usually associated with peripheral eosinophilia. It presents during adulthood with symmetrical and painful swelling of mainly the extremities that progressively become indurated. Fatigue, disabling cutaneous fibrosis, myositis and arthritis may also be observed.

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Narrow down the case reports

Total: 236 (papers)

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Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (45.3%)	7134742	Multisystem presentation of eosinophilic fasciitis. Caspi D, Fishel R, Varon M, Yona E, Baratz M, Yaron M. Rheumatol Rehabil. 1982;21(4):218-21. [ Show abstract ] [ Hide abstract ]
		Proteinuria Splenomegaly Eosinophilia


		Adult Blood Sedimentation Bone Marrow Examination Eosinophilia Fasciitis Homo sapiens Hypergammaglobulinemia Male Myositis Proteinuria Skin Splenomegaly
2 (42.8%)	20181119 (2830980)	Unusual presentation of eosinophilic fasciitis: two case reports and a review of the literature. Danis R, Akbulut S, Altintas A, Ozmen S, Ozmen CA. J Med Case Rep. 2010;4:46. [ Show abstract ] [ Hide abstract ]
		Edema Eosinophilia Erythema Cervical lymphadenopathy



2 (42.8%)	8809452	Eosinophilic fasciitis in an adolescent girl with lymphadenopathy and vitiligo-like and linear scleroderma-like changes. A case report. Stork J, Nemcova D, Hoza J, Kodetova D. Clin Exp Rheumatol. 1996;14(3):337-41. [ Show abstract ] [ Hide abstract ]
		Edema Lymphadenopathy Erythema Hypereosinophilia


		Antibodies, Antinuclear Autoantibodies Biopsy Eosinophilia Fasciitis Females Giant Cell Granuloma Homo sapiens Skin Systemic Scleroderma Vitiligo
4 (38.2%)	29292619	[EOSINOPHILIC FASCIITIS (EF)]. Ben Shabat A, Amarilyo G, Stein J, Harel L. Harefuah. 2017;156(12):786-790. [ Show abstract ] [ Hide abstract ]
		Edema Eosinophilia Erythema


		Adrenal Cortex Hormones Differential Diagnosis Eosinophilia Fasciitis Homo sapiens Male Myalgia
4 (38.2%)	23289259	[Eosinophilic fasciitis--a case report]. Sokolik R, Matuszewska A, Swierkot J, Wiland P. Wiad Lek. 2012;65(2):138-41. [ Show abstract ] [ Hide abstract ]
		Edema Eosinophilia Erythema


		Eosinophilia Fascia Fasciitis Females Fibrosis Homo sapiens
6 (37.6%)	1522976	[The observations in a case of eosinophilic fasciitis]. Bizzarri F, Montanaro M, Della Casa GP, Dambruoso V, Menchinelli M, Mecali C. Minerva Med. 1992;83(7-8):487-9. [ Show abstract ] [ Hide abstract ]
		Eosinophilia Anemia Fever


		Biopsy Eosinophilia Fasciitis Homo sapiens Male Middle Aged Skin
7 (36.6%)	25226017	Eosinophilic fasciitis-like disorder developing in the setting of multiple sclerosis therapy. Sheu J, Kattapuram SV, Stankiewicz JM, Merola JF. J Drugs Dermatol. 2014;13(9):1144-7. [ Show abstract ] [ Hide abstract ]
		Edema Eosinophilia Flushing


		Adult Eosinophilia Fasciitis Fumarates Homo sapiens Immunosuppressive Agents Male Multiple Sclerosis
8 (36.5%)	19513726	[Eosinophilic fasciitis and asplenia]. Baerlecken NT, Melzer A, Schmidt RE, Witte T. Z Rheumatol. 2009;68(8):695-6, 698. [ Show abstract ] [ Hide abstract ]
		Glomerulonephritis Asplenia Thrombocytopenia


		Differential Diagnosis Eosinophilia Fasciitis Females Homo sapiens Middle Aged Syndrome
9 (34.8%)	25710860	Chronic graft-versus-host disease presenting as eosinophilic fasciitis: therapeutic challenges and an additional case. Ganta CC, Chatterjee S, Pohlman B, Hojjati M. J Clin Rheumatol. 2015;21(2):86-94. [ Show abstract ] [ Hide abstract ]
		Eosinophilia Morphea Peau d'orange


		Adult Eosinophilia Fasciitis Graft-vs-Host Disease Hodgkin Disease Homo sapiens Male
9 (34.8%)	25434081	Association of eosinophilic fasciitis with morphea. Zisova LG, Abadjieva CI, Obreshkova EV, Chernev GK, Vutova NI. Folia Med (Plovdiv). 2014;56(3):220-4. [ Show abstract ] [ Hide abstract ]
		Hashimoto thyroiditis Edema Vitiligo Eosinophilia


		Adult Eosinophilia Fasciitis Females Homo sapiens

Phenotype(s) retrieved from Orphanet

Total: 16

HPO ID	Term	Frequency
HP:0000969	Edema	Very frequent (99-80%)
HP:0001063	Acrocyanosis	Very frequent (99-80%)
HP:0001482	Subcutaneous nodule	Very frequent (99-80%)
HP:0001879	Abnormal eosinophil morphology	Very frequent (99-80%)
HP:0001880	Eosinophilia	Very frequent (99-80%)
HP:0003326	Myalgia	Very frequent (99-80%)
HP:0012378	Fatigue	Very frequent (99-80%)
HP:0012733	Macule	Very frequent (99-80%)
HP:0100658	Cellulitis	Very frequent (99-80%)
HP:0100748	Muscular edema	Very frequent (99-80%)
HP:0001369	Arthritis	Frequent (79-30%)
HP:0002829	Arthralgia	Frequent (79-30%)
HP:0001824	Weight loss	Occasional (29-5%)
HP:0003401	Paresthesia	Occasional (29-5%)
HP:0100537	Fasciitis	Occasional (29-5%)
HP:0100614	Myositis	Occasional (29-5%)

Phenotype(s) retrieved from case reports

Total: 66

HPO ID	Term	# of case reports
HP:0001880	Eosinophilia	60
HP:0003326	Myalgia	20
HP:0012344	Morphea	16
HP:0100537	Fasciitis	13
HP:0000969	Edema	9
HP:0001369	Arthritis	7
HP:0032061	Hypereosinophilia	7
HP:0001370	Rheumatoid arthritis	5
HP:0012490	Panniculitis	5
HP:0100614	Myositis	4
HP:0001045	Vitiligo	3
HP:0001909	Leukemia	3
HP:0002829	Arthralgia	3
HP:0001271	Polyneuropathy	2
HP:0002664	Neoplasm	2
HP:0002716	Lymphadenopathy	2
HP:0004859	Amegakaryocytic thrombocytopenia	2
HP:0010783	Erythema	2
HP:0012398	Peripheral edema	2
HP:0025533	Peau d'orange	2
HP:0100646	Thyroiditis	2
HP:0000099	Glomerulonephritis	1
HP:0000112	Nephropathy	1
HP:0000822	Hypertension	1
HP:0000836	Hyperthyroidism	1
HP:0000854	Thyroid adenoma	1
HP:0000872	Hashimoto thyroiditis	1
HP:0000979	Purpura	1
HP:0001250	Seizures	1
HP:0001298	Encephalopathy	1
HP:0001371	Flexion contracture	1
HP:0001386	Joint swelling	1
HP:0001744	Splenomegaly	1
HP:0001746	Asplenia	1
HP:0001876	Pancytopenia	1
HP:0001894	Thrombocytosis	1
HP:0001903	Anemia	1
HP:0001945	Fever	1
HP:0001970	Tubulointerstitial nephritis	1
HP:0001974	Leukocytosis	1
HP:0002099	Asthma	1
HP:0002113	Pulmonary infiltrates	1
HP:0002253	Colonic diverticula	1
HP:0002583	Colitis	1
HP:0002861	Melanoma	1
HP:0002878	Respiratory failure	1
HP:0002907	Microscopic hematuria	1
HP:0002955	Granulomatosis	1
HP:0003072	Hypercalcemia	1
HP:0003198	Myopathy	1
HP:0003323	Progressive muscle weakness	1
HP:0003565	Elevated erythrocyte sedimentation rate	1
HP:0006846	Acute encephalopathy	1
HP:0007105	Infantile encephalopathy	1
HP:0007141	Sensorimotor neuropathy	1
HP:0009830	Peripheral neuropathy	1
HP:0012115	Hepatitis	1
HP:0012315	Histiocytoma	1
HP:0012593	Nephrotic range proteinuria	1
HP:0012819	Myocarditis	1
HP:0025142	Constitutional symptom	1
HP:0030731	Carcinoma	1
HP:0030880	Raynaud phenomenon	1
HP:0032252	Granuloma	1
HP:0100658	Cellulitis	1
HP:0100769	Synovitis	1

Causative gene(s) retrieved from Orphanet

Total: 0

Gene Symbol	Gene Name	Entrez Gene ID