| Rank (Similarity) |
PMID (PMCID) |
|
|---|---|---|
| 1 (17.5%) |
31260413 |
Low-Dose Intrathecal Ziconotide for Spasticity From Primary Lateral Sclerosis: A Case Report. Zhu X, Kohan LR, Goldstein RB. A A Pract. 2019;13(1):31-33. |
| Spasticity | ||
| Adult Females Homo sapiens Injections, Spinal Motor Neuron Disease Muscle Spasticity Pain omega-Conotoxins | ||
| 1 (17.5%) |
30631918 |
Mills' syndrome revisited. Jaiser SR, Mitra D, Williams TL, Baker MR. J Neurol. 2019;266(3):667-679. |
| Spastic hemiparesis | ||
| CSF2 | ||
| Electromyography Evoked Potentials, Motor Females Hemiplegia Homo sapiens Magnetic Resonance Imaging Male Motor Neuron Disease | ||
| 1 (17.5%) |
30154300 |
[Obstructive sleep apnea hypopnea syndrome and alveolar hypoventilation syndrome in motor neuron disease: A case report and literature review]. Zhou L, Ouyang R, Chen P, Luo H, Wu B, Liu G. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018;43(1):106-112. |
| Bulbar palsy | ||
| Hemosiderosis Homo sapiens Male Middle Aged Motor Neuron Disease Polysomnography Retrospective Studies Sleep Apnea, Obstructive | ||
| 1 (17.5%) |
28745069 |
A case series of PLS patients with frontotemporal dementia and overview of the literature. de Vries BS, Rustemeijer LMM, van der Kooi AJ, Raaphorst J, Schroder CD, Nijboer TCW, Hendrikse J, Veldink JH, van den Berg LH, van Es MA. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(7-8):534-548. |
| Progressive spasticity | ||
| Differential Diagnosis Females Homo sapiens Male Middle Aged Motor Neuron Disease Symptom Assessment | ||
| 1 (17.5%) |
23944734 |
Clinical variability and female penetrance in X-linked familial FTD/ALS caused by a P506S mutation in UBQLN2. Vengoechea J, David MP, Yaghi SR, Carpenter L, Rudnicki SA. Amyotroph Lateral Scler Frontotemporal Degener. 2013;14(7-8):615-9. |
| Dysarthria Bulbar palsy | ||
| UBQLN2 | ||
| p|SUB|P|506|S | ||
| Adaptor Proteins, Signal Transducing Adult Amyotrophic Lateral Sclerosis Autophagy-Related Proteins Cell Cycle Proteins Females Homo sapiens Male Middle Aged Mutation Penetrance Ubiquitins Young Adult | ||
| 1 (17.5%) |
23026537 |
Progressive supranuclear palsy presenting as primary lateral sclerosis but lacking parkinsonism, gaze palsy, aphasia, or dementia. Nagao S, Yokota O, Nanba R, Takata H, Haraguchi T, Ishizu H, Ikeda C, Takeda N, Oshima E, Sakane K, Terada S, Ihara Y, Uchitomi Y. J Neurol Sci. 2012;323(1-2):147-53. |
| Dementia Spastic gait | ||
| Astrocytes Coiled Bodies DNA-Binding Proteins Deglutition Disorders Diagnostic Errors Differential Diagnosis Disease Progression Dysarthria Females Gait Disorders, Neurologic Gliosis Homo sapiens Motor Neuron Disease Motor Neurons Muscle Spasticity Reflex, Abnormal Symptom Assessment TDP-43 Proteinopathies tau Proteins | ||
| 1 (17.5%) |
21369848 |
Anti-Ma2/Ta antibodies in a woman with primary lateral sclerosis-like phenotype and Sjogren syndrome. Piccolo G, Tavazzi E, Jarius S, Alfonsi E, Cavagna L, Piccolo L, Zardini E, Voltz R, Franciotta D. Neurol Sci. 2011;32(5):915-7. |
| Autoimmunity Progressive spastic paraparesis | ||
| Antigens, Neoplasm Autoantibodies Females Homo sapiens Middle Aged Motor Neuron Disease Nerve Tissue Proteins Ribonucleoproteins Sjogren's Syndrome | ||
| 1 (17.5%) |
20532474 |
[Slowly progressive dysarthria in primary lateral sclerosis]. Urban PP, Wellach I, Pohlmann C. Nervenarzt. 2010;81(8):986-8, 990-1. |
| Spasticity | ||
| Aged, 80 and over Amyotrophic Lateral Sclerosis Differential Diagnosis Disease Progression Electromyography Evoked Potentials Females Homo sapiens Magnetic Resonance Imaging Mobility Limitation Motor Neuron Disease Neurologic Examination Pseudobulbar Palsy Spastic Paraplegia, Hereditary Tongue | ||
| 1 (17.5%) |
18385632 |
Intrathecal baclofen bolus complicated by deep vein thrombosis and pulmonary embolism. A case report. Carda S, Cazzaniga M, Taiana C, Pozzi R. Eur J Phys Rehabil Med. 2008;44(1):87-8. |
| Lower limb spasticity | ||
| Differential Diagnosis Echocardiography Females Homo sapiens Motor Neuron Disease Muscle Relaxants, Central Muscle Spasticity Pulmonary Embolism Venous Thrombosis | ||
| 1 (17.5%) |
18262342 |
Pure primary lateral sclerosis--Case reports. Tomik B, Zur KA, Szczudlik A. Clin Neurol Neurosurg. 2008;110(4):387-91. |
| Spasticity | ||
| Adult Disease Progression Dysarthria Females Follow-Up Studies Homo sapiens Male Motor Neuron Disease Neurologic Examination Paraparesis, Spastic Prospective Studies |
Total: 18
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0001257 | Spasticity | Very frequent (99-80%) |
| HP:0002127 | Abnormal upper motor neuron morphology | Very frequent (99-80%) |
| HP:0002493 | Upper motor neuron dysfunction | Very frequent (99-80%) |
| HP:0003487 | Babinski sign | Very frequent (99-80%) |
| HP:0007034 | Generalized hyperreflexia | Very frequent (99-80%) |
| HP:0002015 | Dysphagia | Frequent (79-30%) |
| HP:0002064 | Spastic gait | Frequent (79-30%) |
| HP:0002200 | Pseudobulbar signs | Frequent (79-30%) |
| HP:0002371 | Loss of speech | Frequent (79-30%) |
| HP:0002464 | Spastic dysarthria | Frequent (79-30%) |
| HP:0003444 | EMG: chronic denervation signs | Frequent (79-30%) |
| HP:0007199 | Progressive spastic paraparesis | Frequent (79-30%) |
| HP:0010549 | Weakness due to upper motor neuron dysfunction | Frequent (79-30%) |
| HP:0006827 | Atrophy of the spinal cord | Occasional (29-5%) |
| HP:0007002 | Motor axonal neuropathy | Occasional (29-5%) |
| HP:0010873 | Cervical spinal cord atrophy | Occasional (29-5%) |
| HP:0002366 | Abnormal lower motor neuron morphology | Excluded (0%) |
| HP:0003474 | Sensory impairment | Excluded (0%) |
Total: 23
| HPO ID | Term | # of case reports |
|---|---|---|
| HP:0001257 | Spasticity | 6 |
| HP:0001300 | Parkinsonism | 3 |
| HP:0002061 | Lower limb spasticity | 2 |
| HP:0000726 | Dementia | 1 |
| HP:0000819 | Diabetes mellitus | 1 |
| HP:0001260 | Dysarthria | 1 |
| HP:0001283 | Bulbar palsy | 1 |
| HP:0001285 | Spastic tetraparesis | 1 |
| HP:0001324 | Muscle weakness | 1 |
| HP:0001325 | Hypoglycemic coma | 1 |
| HP:0001337 | Tremor | 1 |
| HP:0002067 | Bradykinesia | 1 |
| HP:0002172 | Postural instability | 1 |
| HP:0002191 | Progressive spasticity | 1 |
| HP:0002333 | Motor deterioration | 1 |
| HP:0002381 | Aphasia | 1 |
| HP:0003470 | Paralysis | 1 |
| HP:0003701 | Proximal muscle weakness | 1 |
| HP:0007269 | Spinal muscular atrophy | 1 |
| HP:0010535 | Sleep apnea | 1 |
| HP:0012224 | Circulating immune complexes | 1 |
| HP:0030078 | Lung adenocarcinoma | 1 |
| HP:0100315 | Lewy bodies | 1 |