Pure autonomic failure

Pure autonomic failure (PAF) is a neurodegenerative disease that affects the sympathetic branch of the autonomous nervous system and that manifests with orthostatic hypotension.



Input patient's signs and symptoms


Narrow down the case reports



Total: 73 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(27.7%)		 8140921
 [Pure autonomic failure].
Ducla-Soares JL, Guerreiro AS, Povoa P, Alvares E, Guerreiro L, Carrilho F, Santos M, Figueirinhas J, Carvalho M.
Acta Med Port. 1993;6(11):533-7.
Xerostomia
Combination Drug Therapy Differential Diagnosis Females Homo sapiens Middle Aged
2
(22.8%)		 9396365
 [A case of idiopathic orthostatic hypotension with selective involvement of postganglionic noradrenergic neurons].
Kashihara K, Manabe Y, Sakai K, Shiro Y, Shohmori T.
Rinsho Shinkeigaku. 1997;37(7):645-8.
Impotence Talipes
Adult Homo sapiens Hypotension, Orthostatic Male
3
(21.2%)		 30828233
 Droxidopa for Hypotension of Different Etiologies: Two Case Reports.
Oommen J, Chen J, Wang S, Caraccio T, Hanna A.
P T. 2019;44(3):125-144.
Orthostatic hypotension Rheumatoid arthritis
DBH DDC
4
(17.5%)		 18556705
 Vagolysis.
Hutchinson CD, Jardine DL, Hurrell M.
Age Ageing. 2008;37(5):602-4.
Hypertension Scarring
Baroreflex Blood Pressure Catecholamines Differential Diagnosis Ear Neoplasms Fatal Outcome Homo sapiens Hypotension, Orthostatic Magnetic Resonance Imaging Male Sympathetic Nervous System Vagus Nerve Disorder
4
(17.5%)		 14564656
 Botulism type B presenting as pure autonomic dysfunction.
Merz B, Bigalke H, Stoll G, Naumann M.
Clin Auton Res. 2003;13(5):337-8.
Muscle weakness
Adult Botulism Cholinergic Fibers Differential Diagnosis Foodborne Disease Homo sapiens Male
4
(17.5%)		 1633761
 [The Shy-Drager syndrome].
Freistuhler M, Passenberg P, Burger M.
Dtsch Med Wochenschr. 1992;117(30):1146-8.
Urinary incontinence Gastroparesis
Bandage Combination Drug Therapy Combined Modality Therapy Differential Diagnosis Females Homo sapiens Hypotension, Orthostatic Shy-Drager Syndrome
7
(4.0%)		 30687067
 Pure Autonomic Failure with Asymptomatic Hypertensive Urgency: A Case Report and Literature Review.
Aljohar A, Muayqil T, Aldeeri A, Jammah A, Hersi A, Alhabib K.
Case Rep Neurol. 2018;10(3):357-362.
Hypertension
7
(4.0%)		 28670690
 Possible Involvement of Hypotension in Postprandial Headache: A Case Series.
Takizawa T, Shibata M, Hiraide T, Seki M, Takahashi S, Suzuki N.
Headache. 2017;57(9):1443-1448.
Headache
Adrenergic alpha-1 Receptor Agonists Adult Females Glycoside Hydrolase Inhibitors Headache Homo sapiens Hypotension Postprandial Period
7
(4.0%)		 28188385
 Pure autonomic failure without synucleinopathy.
Isonaka R, Holmes C, Cook GA, Sullivan P, Sharabi Y, Goldstein DS.
Clin Auton Res. 2017;27(2):97-101.
Orthostatic hypotension
SNCA
Follow-Up Studies Homo sapiens Male Middle Aged Pure Autonomic Failure Valsalva Maneuver alpha-Synuclein
7
(4.0%)		 26294216
 Middle Cerebral Artery Occlusion Presenting as Upper Limb Monochorea.
Noda K, Nakajima S, Sasaki F, Ito Y, Kawajiri S, Tomizawa Y, Hattori N, Yamamoto T, Okuma Y.
J Stroke Cerebrovasc Dis. 2015;24(10):e291-3.
Orthostatic hypotension
Chorea Diffusion Magnetic Resonance Imaging Homo sapiens Imaging, Three-Dimensional Infarction, Middle Cerebral Artery Magnetic Resonance Angiography Male Upper Extremity
        

Phenotype(s) retrieved from Orphanet

    Total: 10

HPO ID Term Frequency
HP:0000970 Anhidrosis Very frequent (99-80%)
HP:0001278 Orthostatic hypotension Very frequent (99-80%)
HP:0002459 obsolete Dysautonomia Very frequent (99-80%)
HP:0012099 Abnormality of circulating catecholamine level Very frequent (99-80%)
HP:0025142 Constitutional symptom Very frequent (99-80%)
HP:0000020 Urinary incontinence Frequent (79-30%)
HP:0001279 Syncope Frequent (79-30%)
HP:0002019 Constipation Frequent (79-30%)
HP:0100518 Dysuria Frequent (79-30%)
HP:0000802 Impotence Occasional (29-5%)


Phenotype(s) retrieved from case reports

    Total: 23

HPO ID Term # of case reports
HP:0000822 Hypertension 4
HP:0100315 Lewy bodies 4
HP:0001278 Orthostatic hypotension 3
HP:0000726 Dementia 2
HP:0000970 Anhidrosis 2
HP:0001279 Syncope 2
HP:0000020 Urinary incontinence 1
HP:0000651 Diplopia 1
HP:0000802 Impotence 1
HP:0000975 Hyperhidrosis 1
HP:0001271 Polyneuropathy 1
HP:0001300 Parkinsonism 1
HP:0001324 Muscle weakness 1
HP:0001695 Cardiac arrest 1
HP:0001903 Anemia 1
HP:0002020 Gastroesophageal reflux 1
HP:0002527 Falls 1
HP:0002615 Hypotension 1
HP:0010535 Sleep apnea 1
HP:0012508 Metamorphopsia 1
HP:0012668 Vasovagal syncope 1
HP:0100026 Arteriovenous malformation 1
HP:0100646 Thyroiditis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID