Posterior cortical atrophy

Posterior Cortical Atrophy (PCA) is a rare progressive neurodegenerative disorder with a typical onset between 50-65 years of age characterized by progressive impairment of higher visual processing skills and other posterior cortical functions without any evidence of ocular abnormalities.

Input patient's signs and symptoms

Narrow down the case reports

Total: 83 (papers)

(per page)

Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (23.3%)	25729084	Treatment of a patient with posterior cortical atrophy (PCA) with chiropractic manipulation and Dynamic Neuromuscular Stabilization (DNS): A case report. Francio VT, Boesch R, Tunning M. J Can Chiropr Assoc. 2015;59(1):37-45. [ Show abstract ] [ Hide abstract ]
		Back pain



2 (17.5%)	22906583	Portosystemic shunts: an underdiagnosed but treatable cause of neurological and psychiatric disorders. Degos B, Daelman L, Huberfeld G, Meppiel E, Rabier D, Galanaud D, Magis AS, Lyon-Caen O, Samuel D, Sedel F. J Neurol Sci. 2012;321(1-2):58-64. [ Show abstract ] [ Hide abstract ]
		Psychosis Spastic paraparesis


		Adult Electroencephalography Females Homo sapiens Hyperammonemia Magnetic Resonance Spectroscopy Male Middle Aged Surgical Portosystemic Shunt Ultrasonography Young Adult
3 (4.0%)	30997705	Difficulty differentiating a case of posterior cortical atrophy from a psychogenic disturbance of vision. Kirino E. Psychogeriatrics. 2019;:. [ Show abstract ] [ Hide abstract ]
		Dementia


		Agnosia Differential Diagnosis Females Homo sapiens Middle Aged Perceptual Disorders Tomography, Emission-Computed, Single-Photon Wernicke Aphasia
3 (4.0%)	30817493	A Case of Overlap Posterior Cortical Atrophy and Logopenic Variant Primary Progressive Aphasia. Fitzpatrick D, Blanco-Campal A, Kyne L. Neurologist. 2019;24(2):62-65. [ Show abstract ] [ Hide abstract ]
		Dementia


		Homo sapiens Male Middle Aged Neuropsychological Tests
3 (4.0%)	29914902	Case of posterior cortical atrophy (PCA) evolved to PCA-CBS. Salvadori N, Russo M, Biscetti L, D' Andrea K, Dottorini ME, Parnetti L. BMJ Case Rep. 2018;2018:. [ Show abstract ] [ Hide abstract ]
		Dementia


		Apraxias Biological Markers Dementia Differential Diagnosis Geriatric Assessment Homo sapiens Magnetic Resonance Imaging Male
3 (4.0%)	29864740	Posterior cortical atrophy variant of Alzheimer's dementia-A case report. Mukku SSR, Chintala H, Nagaraj C, Mangalore S, Sivakumar PT, Varghese M. Asian J Psychiatr. 2018;35:109-112. [ Show abstract ] [ Hide abstract ]
		Dementia


		Alzheimer's Disease Homo sapiens Male Middle Aged
3 (4.0%)	29422846 (5803707)	Statokinetic Dissociation (Riddoch Phenomenon) in a Patient with Homonymous Hemianopsia as the First Sign of Posterior Cortical Atrophy. Hayashi R, Yamaguchi S, Narimatsu T, Miyata H, Katsumata Y, Mimura M. Case Rep Neurol. 2017;9(3):256-260. [ Show abstract ] [ Hide abstract ]
		Visual field defect



3 (4.0%)	29072103	Posterior cortical atrophy of a suspected non-Alzheimer type: a case report. Wagner MT, Szeles DM, Mulder B, Sohn M, Walker A. Clin Neuropsychol. 2018;32(4):720-738. [ Show abstract ] [ Hide abstract ]
		Dementia


		Females Homo sapiens Middle Aged Neurodegenerative Disorders Neuropsychological Tests Prospective Studies
3 (4.0%)	28387593	A case of posterior cortical atrophy with vertical neglect. Glazer H, Saadatpour L, Doty L, Heilman KM. Neurocase. 2017;23(2):114-119. [ Show abstract ] [ Hide abstract ]
		Dementia


		Brain Diseases Homo sapiens Magnetic Resonance Imaging Male Neurologic Examination Neuropsychological Tests Perceptual Disorders Visual Perception
3 (4.0%)	27896492	Hemianopic line bisection error in a patient with Alzheimer's disease. Kang H, Kim SK, Park KJ, Choi NC, Kwon OY, Lim BH. Neurol Sci. 2017;38(3):489-491. [ Show abstract ] [ Hide abstract ]
		Hemianopia


		Alzheimer's Disease Females Hemianopsia Homo sapiens Middle Aged

Phenotype(s) retrieved from Orphanet

Total: 21

HPO ID	Term	Frequency
HP:0000657	Oculomotor apraxia	Very frequent (99-80%)
HP:0000739	Anxiety	Very frequent (99-80%)
HP:0001251	Ataxia	Very frequent (99-80%)
HP:0001289	Confusion	Very frequent (99-80%)
HP:0002442	Dyscalculia	Very frequent (99-80%)
HP:0010523	Alexia	Very frequent (99-80%)
HP:0010524	Agnosia	Very frequent (99-80%)
HP:0010525	Finger agnosia	Very frequent (99-80%)
HP:0010526	Dysgraphia	Very frequent (99-80%)
HP:0100704	Cerebral visual impairment	Very frequent (99-80%)
HP:0000504	Abnormality of vision	Frequent (79-30%)
HP:0000551	Color vision defect	Frequent (79-30%)
HP:0000613	Photophobia	Frequent (79-30%)
HP:0010522	Dyslexia	Frequent (79-30%)
HP:0030217	Limb apraxia	Frequent (79-30%)
HP:0002354	Memory impairment	Occasional (29-5%)
HP:0002367	Visual hallucinations	Occasional (29-5%)
HP:0002463	Language impairment	Occasional (29-5%)
HP:0002494	Abnormal rapid eye movement sleep	Occasional (29-5%)
HP:0011098	Speech apraxia	Occasional (29-5%)
HP:0030216	Inertia	Occasional (29-5%)

Phenotype(s) retrieved from case reports

Total: 25

HPO ID	Term	# of case reports
HP:0000726	Dementia	16
HP:0010523	Alexia	11
HP:0030222	Visual agnosia	5
HP:0002381	Aphasia	3
HP:0010528	Prosopagnosia	3
HP:0002059	Cerebral atrophy	2
HP:0002186	Apraxia	2
HP:0010522	Dyslexia	2
HP:0000505	Visual impairment	1
HP:0000518	Cataract	1
HP:0000709	Psychosis	1
HP:0000746	Delusions	1
HP:0001300	Parkinsonism	1
HP:0001336	Myoclonus	1
HP:0002185	Neurofibrillary tangles	1
HP:0002442	Dyscalculia	1
HP:0002463	Language impairment	1
HP:0003470	Paralysis	1
HP:0010524	Agnosia	1
HP:0010525	Finger agnosia	1
HP:0010526	Dysgraphia	1
HP:0012532	Chronic pain	1
HP:0030784	Anomia	1
HP:0031868	Optic ataxia	1
HP:0100315	Lewy bodies	1

Causative gene(s) retrieved from Orphanet

Total: 0

Gene Symbol	Gene Name	Entrez Gene ID