Pigmented villonodular synovitis

Pigmented villonodular synovitis (PVNS) is a rare benign proliferative disorder of the synovial membrane primarily affecting young adults (with a peak age of onset in the second to fourth decade of life) characterized by proliferative, locally invasive tumor-like lesions, usually involving a single joint, tendon sheath or bursa (most commonly the joints of the knee and hip and rarely others such as the ankle, shoulder and temporomandibular joints). It presents with pain and limitation of motion along with swelling, heat and tenderness over the involved joint, eventually leading to arthritic degeneration and significant locomotor deficit, if left untreated. PVNS can recur in patients even after treatment.



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Total: 258 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
1
(49.0%)
25577961
Recurrent pigmented villonodular synovitis and multifocal giant cell tumor of the tendon sheath: case report.
Wang JP, Rancy SK, DiCarlo EF, Wolfe SW.
J Hand Surg Am. 2015;40(3):537-41.
Overgrowth Small finger
Adult Females Follow-Up Studies Giant Cell Tumors Health Risk Assessment Homo sapiens Immunohistochemistry Neoplasm Invasiveness Neoplasm Recurrence, Local Rare Diseases
1
(49.0%)
11036550
[Malignant course of pigmented villonodular synovitis of the flexor tendon sheath of the small finger--case report and review of the literature].
Huracek J, Troeger H, Menghiardi B, Jundt G, Nurnberger H, Herrmann R, Landmann C.
Handchir Mikrochir Plast Chir. 2000;32(4):283-90.
Pulmonary insufficiency Small finger
Follow-Up Studies Homo sapiens Lung Lung Neoplasms Magnetic Resonance Imaging Male Middle Aged Neoplastic Cell Transformation Soft Tissue Neoplasms Synovectomy Synovial Membrane
3
(42.7%)
25699525
Pigmented villonodular synovitis of the temporomandibular joint with intracranial extension.
Chen Y, Cai XY, Yang C, Chen MJ, Qiu YT, Zhuo Z.
J Craniofac Surg. 2015;26(2):e115-8.
Trismus
Females Homo sapiens Magnetic Resonance Imaging Middle Aged Temporomandibular Joint Temporomandibular Joint Disorders
3
(42.7%)
14569704
Pigmented villonodular synovitis of the temporomandibular joint: a report of two cases.
Church CA, Rowe M, Llaurado R, Liwnicz BH, Martin PA.
Ear Nose Throat J. 2003;82(9):692-5.
Trismus
Adult Homo sapiens Male Temporomandibular Joint Disorders X-Ray Computed Tomography
3
(42.7%)
6726846
Pigmented villonodular synovitis of the temporomandibular joint.
O'Sullivan TJ, Alport EC, Whiston HG.
J Otolaryngol. 1984;13(2):123-6.
Trismus
Differential Diagnosis Females Head and Neck Neoplasms Homo sapiens Middle Aged Synovitis Temporomandibular Joint Disorders
6
(33.8%)
26266013
(4508644)
Fine Needle Aspiration Cytology of Chondroid Tenosynovial Giant Cell Tumor of the Hand.
Abdou AG, Aiad H, Youssef Asaad N.
Rare Tumors. 2015;7(2):5814.
Wrist swelling
7
(32.2%)
19037845
Vascularized iliac bone graft in cases of ankle tuberculosis.
Yoshida T, Sakamoto A, Iwamoto Y.
J Reconstr Microsurg. 2009;25(2):125-31.
Osteomyelitis Osteoarthritis Pseudoarthrosis
Bone Transplantation Females Homo sapiens Middle Aged Tuberculosis, Osteoarticular
8
(31.4%)
25709168
(4329690)
PVNS or pseudo aneurysm: MRI-problem solving or misleading?
Sannananja B, Shah HU, Laxman V, Nagesh C.
Indian J Radiol Imaging. 2015;25(1):60-2.
Recurrent shoulder dislocation
8
(31.4%)
20806759
Arthroscopic treatment of pigmented villonodular synovitis involving bilateral shoulders.
Koh KH, Lim KS, Yoo JC.
Orthopedics. 2010;33(6):442.
Rotator cuff tear
Arthroscopy Differential Diagnosis Follow-Up Studies Homo sapiens Magnetic Resonance Imaging Male Middle Aged Synovectomy
8
(31.4%)
19252895
Subacromial bony erosion: a rare presentation of pigmented villonodular synovitis of the shoulder.
Ji JH, Shafi M, Park SE, Kim WY.
Knee Surg Sports Traumatol Arthrosc. 2009;17(5):534-8.
Rotator cuff tear
Acromion Arthroscopy Females Homo sapiens Magnetic Resonance Imaging Rotator Cuff Rotator Cuff Injuries Shoulder Pain
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 40

HPO ID Term # of case reports
HP:0001370 Rheumatoid arthritis 15
HP:0002664 Neoplasm 13
HP:0001028 Hemangioma 7
HP:0001369 Arthritis 7
HP:0002835 Aspiration 7
HP:0100769 Synovitis 7
HP:0012032 Lipoma 5
HP:0002758 Osteoarthritis 4
HP:0030839 Knee pain 4
HP:0002861 Melanoma 3
HP:0003040 Arthropathy 3
HP:0010614 Fibroma 3
HP:0025232 Bursitis 3
HP:0100242 Sarcoma 3
HP:0000934 Chondrocalcinosis 2
HP:0001289 Confusion 2
HP:0001386 Joint swelling 2
HP:0030432 Chondroblastoma 2
HP:0030731 Carcinoma 2
HP:0030838 Hip pain 2
HP:0032252 Granuloma 2
HP:0100246 Osteoma 2
HP:0000316 Hypertelorism 1
HP:0000369 Low-set ears 1
HP:0000592 Blue sclerae 1
HP:0000718 Aggressive behavior 1
HP:0001548 Overgrowth 1
HP:0002212 Curly hair 1
HP:0002716 Lymphadenopathy 1
HP:0002754 Osteomyelitis 1
HP:0003002 Breast carcinoma 1
HP:0003095 Septic arthritis 1
HP:0003304 Spondylolysis 1
HP:0007461 Hemangiomatosis 1
HP:0030033 Small finger 1
HP:0030431 Osteochondroma 1
HP:0030840 Ankle pain 1
HP:0031625 Pseudoaneurysm 1
HP:0032201 Rotator cuff tear 1
HP:0100658 Cellulitis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID