Cancer-associated retinopathy

Cancer associated retinopathy (CAR) is a paraneoplastic disease of the eye associated with the presence of extraocular malignancy and circulating autoantibodies against retinal proteins.

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Narrow down the case reports

Total: 107 (papers)

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Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (25.1%)	22569848 (3491897)	Bilateral paraneoplastic optic neuropathy and unilateral retinal compromise in association with prostate cancer: a differential diagnostic challenge in a patient with unexplained visual loss. Carboni G, Forma G, Bond AD, Adamus G, Iannaccone A. Doc Ophthalmol. 2012;125(1):63-70. [ Show abstract ] [ Hide abstract ]
		Visual loss Central retinal artery occlusion


		Autoantibodies Autoantigens Differential Diagnosis Electroretinography Fluorescein Angiography Homo sapiens Male Optic Nerve Paraneoplastic Syndromes, Ocular Prostatic Neoplasms Retina Retinal Artery Occlusion Tomography, Optical Coherence Vision Disorders Visual Acuity Visual Fields Western Blotting
2 (4.0%)	31046716	A case of cancer-associated retinopathy with chorioretinitis and optic neuritis associated with occult small cell lung cancer. Carrera W, Tsamis KA, Shah R. BMC Ophthalmol. 2019;19(1):101. [ Show abstract ] [ Hide abstract ]
		Retinopathy


		Chorioretinitis Females Homo sapiens Lung Neoplasms Middle Aged Optic Neuritis Paraneoplastic Syndromes, Ocular
2 (4.0%)	30723523	Cancer-associated Retinopathy Developing After 10 Years of Complete Breast Cancer Remission. Igarashi N, Sawamura H, Kaburaki T, Aihara M. Neuroophthalmology. 2019;43(1):36-42. [ Show abstract ] [ Hide abstract ]
		Visual loss
		RCVRN


2 (4.0%)	29554055	REVERSIBLE NYCTALOPIA ASSOCIATED WITH VITAMIN A DEFICIENCY AFTER RESECTED MALIGNANT ILEAL CARCINOID AND PANCREATIC ADENOCARCINOMA. Hansen BA, Mendoza-Santiesteban CE, Hedges TR 3rd. Retin Cases Brief Rep. 2018;12(2):127-130. [ Show abstract ] [ Hide abstract ]
		Retinopathy


		Adenocarcinoma Carcinoid Tumor Homo sapiens Ileal Neoplasms Male Middle Aged Nyctalopia Pancreatic Neoplasm Paraneoplastic Syndromes, Ocular Vitamin A Deficiency Vitamins
2 (4.0%)	29503967 (5758029)	Improvements of visual function and outer retinal morphology following spontaneous regression of cancer in anti-recoverin cancer-associated retinopathy. Suimon Y, Saito W, Hirooka K, Kanda A, Kitai H, Sakakibara-Konishi J, Ishida S. Am J Ophthalmol Case Rep. 2017;5:137-140. [ Show abstract ] [ Hide abstract ]
		Falls



2 (4.0%)	29362998 (5780336)	Cancer-associated retinopathy after surgery for breast cancer: a case report and review of the literature. Kamei M, Fujitomi Y, Kondo Y, Adachi T, Shibata K, Takumi Y, Abe M, Sugio K. Surg Case Rep. 2018;4(1):10. [ Show abstract ] [ Hide abstract ]
		Central scotoma



2 (4.0%)	29260107 (5731551)	Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy. Irizarry FJ, Kopplin LJ, Salek SS, Adamus G, Saleh M, Biggee K, Lin P, Rosenbaum JT. Am J Ophthalmol Case Rep. 2017;8:11-13. [ Show abstract ] [ Hide abstract ]
		Ovarian carcinoma



2 (4.0%)	28815346	Unilateral cancer-associated retinopathy: diagnosis, serology and treatment. Roels D, Ueno S, Talianu CD, Draganova D, Kondo M, Leroy BP. Doc Ophthalmol. 2017;135(3):233-240. [ Show abstract ] [ Hide abstract ]
		Central scotoma
		PLXNA2 TRPM1

		Adenocarcinoma Antineoplastic Agents, Immunological Females Homo sapiens Middle Aged Paraneoplastic Syndromes, Ocular Retinal Diseases Steroids
2 (4.0%)	28382556 (5427140)	Acute progressive paravascular placoid neuroretinopathy with negative-type electroretinography in paraneoplastic retinopathy. Chen FK, Chew AL, Zhang D, Chen SC, Chelva E, Chandrasekera E, Koay EMH, Forrester J, McLenachan S. Doc Ophthalmol. 2017;134(3):227-235. [ Show abstract ] [ Hide abstract ]
		Carcinoma
		GAPDH RCVRN

		Acute Disease Electroretinography Homo sapiens Male Middle Aged Multimodal Imaging Paraneoplastic Syndromes Retina Retinal Diseases
2 (4.0%)	28121717	Normal-Tension Glaucoma Masqueraders: Detection Using Optical Coherence Tomography. Kuo DS, Asrani S. J Glaucoma. 2017;26(4):e153-e156. [ Show abstract ] [ Hide abstract ]
		Glaucoma


		Adult Differential Diagnosis Females Homo sapiens Low Tension Glaucoma Male Middle Aged Nerve Fibers Ophthalmoscopy Optic Disk Retinal Ganglion Cells Retrospective Studies Tomography, Optical Coherence

Phenotype(s) retrieved from Orphanet

Total: 0

HPO ID	Term	Frequency

Phenotype(s) retrieved from case reports

Total: 32

HPO ID	Term	# of case reports
HP:0000488	Retinopathy	13
HP:0030731	Carcinoma	12
HP:0000572	Visual loss	11
HP:0002861	Melanoma	11
HP:0012056	Cutaneous melanoma	5
HP:0000618	Blindness	4
HP:0030357	Small cell lung carcinoma	4
HP:0000546	Retinal degeneration	3
HP:0000608	Macular degeneration	2
HP:0001138	Optic neuropathy	2
HP:0002664	Neoplasm	2
HP:0000505	Visual impairment	1
HP:0000529	Progressive visual loss	1
HP:0000541	Retinal detachment	1
HP:0000543	Optic disc pallor	1
HP:0000613	Photophobia	1
HP:0001123	Visual field defect	1
HP:0001271	Polyneuropathy	1
HP:0002860	Squamous cell carcinoma	1
HP:0002960	Autoimmunity	1
HP:0003002	Breast carcinoma	1
HP:0007902	Vitreous hemorrhage	1
HP:0011505	Cystoid macular edema	1
HP:0011506	Choroidal neovascularization	1
HP:0011531	Vitritis	1
HP:0012114	Endometrial carcinoma	1
HP:0012424	Chorioretinitis	1
HP:0025318	Ovarian carcinoma	1
HP:0030358	Non-small cell lung carcinoma	1
HP:0031273	Shock	1
HP:0100242	Sarcoma	1
HP:0100653	Optic neuritis	1

Causative gene(s) retrieved from Orphanet

Total: 0

Gene Symbol	Gene Name	Entrez Gene ID