Non-24-hour sleep-wake syndrome

Non-24-hour sleep-wake disorder (non-24 disorder), also known as hypernychthemeral syndrome, is a circadian rhythm sleep disorder characterized by non-synchronization to a 24-hour day leading to insomnia and daytime sleepiness with sometimes severe associated manifestations.



Input patient's signs and symptoms


Narrow down the case reports



Total: 4 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(4.0%)		 15164893
 Association between delayed sleep phase and hypernyctohemeral syndromes: a case study.
Boivin DB, Caliyurt O, James FO, Chalk C.
Sleep. 2004;27(3):417-21.
Sleep disturbance
Adult Amnesia Brain Injuries Chronobiology Disorders Cognition Disorders Females Homo sapiens Magnetic Resonance Imaging Severity of Illness Index Sleep Disorders, Circadian Rhythm Syndrome Time Factors
1
(4.0%)		 9201777
 A multicenter study of sleep-wake rhythm disorders: therapeutic effects of vitamin B12, bright light therapy, chronotherapy and hypnotics.
Yamadera H, Takahashi K, Okawa M.
Psychiatry Clin Neurosci. 1996;50(4):203-9.
Drowsiness
NDUFB3
Adult Chronotherapy Combined Modality Therapy Females Homo sapiens Hypnotics and Sedatives Male Periodicity Phototherapy Sleep Wake Disorders Wakefulness
1
(4.0%)		 6622881
 Successful treatment of human non-24-hour sleep-wake syndrome.
Kamgar-Parsi B, Wehr TA, Gillin JC.
Sleep. 1983;6(3):257-64.
Hypothyroidism
Adult Homo sapiens Male Periodicity Sleep Wake Disorders
1
(4.0%)		 1759094
 Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12).
Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, Terashima M, Okada T, Kasahara Y.
Sleep. 1991;14(5):414-8.
Hypothyroidism
NDUFB3
Achievement Arousal Attention Circadian Rhythms Females Homo sapiens Male Sleep Initiation and Maintenance Disorders Sleep Stages Wakefulness
        

Phenotype(s) retrieved from Orphanet

    Total: 6

HPO ID Term Frequency
HP:0000618 Blindness Frequent (79-30%)
HP:0000716 Depressivity Frequent (79-30%)
HP:0001262 Excessive daytime somnolence Frequent (79-30%)
HP:0002189 Excessive daytime sleepiness Frequent (79-30%)
HP:0012689 Abnormal pineal melatonin secretion Frequent (79-30%)
HP:0025406 Asthenia Frequent (79-30%)


Phenotype(s) retrieved from case reports

    Total: 1

HPO ID Term # of case reports
HP:0002360 Sleep disturbance 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID