Disseminated superficial actinic porokeratosis

Disseminated superficial actinic porokeratosis (DSAP) is the most common form of porokeratosis characterized by the presence of several small annular plaques with a distinctive keratotic rim found most commonly on sun-exposed areas of the skin, particularly the extremities.

Input patient's signs and symptoms

Narrow down the case reports

Total: 27 (papers)

(per page)

Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (17.5%)	21507038	Disseminated superficial actinic porokeratosis treated effectively with topical imiquimod 5% cream. Arun B, Pearson J, Chalmers R. Clin Exp Dermatol. 2011;36(5):509-11. [ Show abstract ] [ Hide abstract ]
		Erythema Scarring


		Administration, Cutaneous Aminoquinolines Drug Administration Schedule Homo sapiens Interferon Inducers Male Porokeratosis
2 (4.0%)	29630163	A report and follow up of a patient with disseminated superficial actinic porokeratosis (DSAP) undergoing novel systemic treatment with palifermin (a keratinocyte growth factor) during chemotherapy. Howard M, Hall A. Dermatol Online J. 2018;24(2):. [ Show abstract ] [ Hide abstract ]
		Basal cell carcinoma
		SERPINB3

		Central Nervous System Neoplasms Follow-Up Studies Homo sapiens Lymphoma Male Porokeratosis Rosacea
2 (4.0%)	28976625	Amelanotic melanoma arising within a lesion of disseminated superficial actinic porokeratosis: An unusual presentation leading to a novel therapeutic approach. Al-Haseni A, Chitgopeker P, Ho JD, Goldberg LJ, Sahni D. Dermatol Ther. 2018;31(1):. [ Show abstract ] [ Hide abstract ]
		Melanoma


		Administration, Cutaneous Antimetabolites, Antineoplastic Bandage Biopsy Females Homo sapiens Melanoma, Amelanotic Neoplastic Cell Transformation Porokeratosis Precancerous Conditions Skin Neoplasms
2 (4.0%)	28922948	Clinical and Dermoscopic Features of Pigmented Disseminated Superficial Actinic Porokeratosis: Case Report and Literature Review. Sotoodian B, Mahmood MN, Salopek TG. J Cutan Med Surg. 2018;22(2):229-231. [ Show abstract ] [ Hide abstract ]
		Erythematous papule


		Back Biopsy Dermoscopy Homo sapiens Male Porokeratosis Skin Sunlight
2 (4.0%)	28398427	Disseminated superficial actinic porokeratosis treated with ingenol mebutate gel 0.05. Anderson I, Routt ET, Jim On SC. Cutis. 2017;99(3):E36-E39. [ Show abstract ] [ Hide abstract ]
		Actinic keratosis


		Administration, Cutaneous Adult Dermatologic Agents Diterpenes Females Homo sapiens Porokeratosis
2 (4.0%)	27468973	Disseminated superficial actinic porokeratosis (DSAP): significant improvement after local administration of calcipotriol/betamethasone gel? Tchernev G, Chokoeva AA, Ivanova B, Mangarov H, Vidolova NG. Wien Med Wochenschr. 2017;167(3-4):85-88. [ Show abstract ] [ Hide abstract ]
		Basal cell carcinoma


		Administration, Topical Aged, 80 and over Combination Drug Therapy Drug Administration Schedule Females Homo sapiens Leg Dermatoses Porokeratosis
2 (4.0%)	27086492	Linear porokeratosis with multiple squamous cell carcinomas successfully treated by electrochemotherapy. Sommerlad M, Lock A, Moir G, McGregor J, Bull R, Cerio R, Harwood C. Br J Dermatol. 2016;175(6):1342-1345. [ Show abstract ] [ Hide abstract ]
		Squamous cell carcinoma


		Antibiotics, Antineoplastic Bowen's Disease Electrochemotherapy Homo sapiens Male Middle Aged Neoplastic Cell Transformation Porokeratosis Skin Neoplasms
2 (4.0%)	25800103	Eruptive disseminated porokeratosis associated with corticosteroid-induced immunosuppression. Bednarek R, Ezra N, Toubin Y, Linos K, Mousdicas N. Clin Exp Dermatol. 2015;40(7):753-6. [ Show abstract ] [ Hide abstract ]
		Asthma


		Adrenal Cortex Hormones Adult Females Homo sapiens Immunosuppressive Agents Porokeratosis
2 (4.0%)	22148029 (3229955)	Squamous Cell Carcinoma Developing within Lesions of Disseminated Superficial Actinic Porokeratosis. Lee HR, Han TY, Son SJ, Lee JH. Ann Dermatol. 2011;23(4):536-8. [ Show abstract ] [ Hide abstract ]
		Squamous cell carcinoma



2 (4.0%)	21933257	Exclusive facial porokeratosis: histopathologically showing follicular cornoid lamellae. Lee Y, Choi EH. J Dermatol. 2011;38(11):1072-5. [ Show abstract ] [ Hide abstract ]
		Macule


		Administration, Topical Adult Face Females Homo sapiens Porokeratosis

Phenotype(s) retrieved from Orphanet

Total: 4

HPO ID	Term	Frequency
HP:0200044	Porokeratosis	Very frequent (99-80%)
HP:0000992	Cutaneous photosensitivity	Frequent (79-30%)
HP:0000989	Pruritus	Occasional (29-5%)
HP:0002860	Squamous cell carcinoma	Occasional (29-5%)

Phenotype(s) retrieved from case reports

Total: 5

HPO ID	Term	# of case reports
HP:0002860	Squamous cell carcinoma	2
HP:0200034	Papule	2
HP:0002664	Neoplasm	1
HP:0020073	Hypopigmented macule	1
HP:0200039	Pustule	1

Causative gene(s) retrieved from Orphanet

Total: 4

Gene Symbol	Gene Name	Entrez Gene ID
MVK	mevalonate kinase	4598
SLC17A9	solute carrier family 17 member 9	63910
MVD	mevalonate diphosphate decarboxylase	4597
FDPS	farnesyl diphosphate synthase	2224