Congenital toxoplasmosis

Congenital toxoplasmosis (CTX) is an embryo-fetopathy characterized by ocular, visceral or intracranial lesions secondary to maternal primo-infection by <i>Toxoplasma gondii</i> (Tg).



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Narrow down the case reports



Total: 131 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(48.9%)		 9582573
 Congenital toxoplasmosis: diagnosis by exfoliative cytology.
Nicol KK, Geisinger KR.
Diagn Cytopathol. 1998;18(5):357-61.
Hepatosplenomegaly Anemia
Anemia Animals Fatal Outcome Homo sapiens Infant Liver Failure Male Toxoplasmosis, Congenital
1
(48.9%)		 8907349
 Congenital toxoplasmosis complicated by central diabetes insipidus in an infant with Down syndrome.
Yamakawa R, Yamashita Y, Yano A, Morita J, Kato H.
Brain Dev. 1996;18(1):75-7.
Hydrocephalus Hepatosplenomegaly Anemia
Animals Diabetes Insipidus Down Syndrome Genes, Protozoan Homo sapiens Infant, Newborn Male Polymerase Chain Reaction Toxoplasma Toxoplasmosis, Congenital X-Ray Computed Tomography
3
(45.3%)		 28728858
 [DRESS complicated by hemophagocytic lymphohistiocytosis in an infant treated for congenital toxoplasmosis].
Rioualen S, Dufau J, Flatres C, Lavenant P, Misery L, Roue JM.
Ann Dermatol Venereol. 2017;144(12):784-787.
Splenomegaly Eosinophilia Fever
IL2
Antiprotozoal Agents Combination Drug Therapy Drug Hypersensitivity Syndrome Fatal Outcome Heart Diseases Homo sapiens Infant Lymphohistiocytosis, Hemophagocytic Myocarditis Toxoplasmosis, Congenital
4
(39.8%)		 12818753
 [Septic shock due to congenital disseminated toxoplasmosis?].
Cneude F, Deliege R, Barbier C, Durand-Joly I, Bourlet A, Sonna M, El Kohen R, Locquet A, Vittu G, Decoster A.
Arch Pediatr. 2003;10(4):326-8.
Purpura Hepatosplenomegaly
Fatal Outcome Females Fluid Therapy Hepatitis Hepatomegaly High-Frequency Jet Ventilation Homo sapiens Immunocompromised Host Infant, Newborn Platelet Transfusion Pneumonia Purpura Septic Shock Splenomegaly Thrombocytopenia Toxoplasmosis, Congenital
5
(39.1%)		 27306134
 Ocular manifestation of congenital toxoplasmosis, clinical implication - case report.
Modrzejewska M, Patalan J, Kulik U, Czeszynska MB.
Ginekol Pol. 2016;87(3):226-30.
Hydrocephalus Splenomegaly Thrombocytopenia
CALM2 RET
Amniotic Fluid DNA, Protozoan Females Fetal Diseases Homo sapiens Infant, Newborn Polymerase Chain Reaction Pregnancy Toxoplasma Toxoplasmosis, Congenital
6
(38.0%)		 29177397
 Not everything is Zika: congenital toxoplasmosis, still prevalent in Colombia?
Alvarado-Socarras JL, Meneses-Silvera K, Zarate-Vergara AC, Guerrero-Gomez C, Rodriguez-Morales AJ.
Rev Peru Med Exp Salud Publica. 2017;34(2):332-336.
Hepatosplenomegaly Thrombocytopenia
Colombia Differential Diagnosis Females Homo sapiens Infant, Newborn Male Toxoplasmosis, Cerebral Toxoplasmosis, Congenital Zika Virus Infection
6
(38.0%)		 21991707
 First case of congenital toxoplasmosis from Nepal.
Rai SK, Sharma A, Shrestha RK, Pradhan P.
Nepal Med Coll J. 2011;13(1):64-6.
Renal insufficiency Hepatosplenomegaly Thrombocytopenia
Antimalarials Antiprotozoal Agents Drug Combinations Fatal Outcome Homo sapiens Infant Male Nepal Toxoplasmosis, Congenital
8
(37.1%)		 15602204
 Severe neonatal toxoplasmosis after third trimester maternal infection.
Armstrong L, Isaacs D, Evans N.
Pediatr Infect Dis J. 2004;23(10):968-9.
Jaundice Thrombocytopenia
Adult Females Homo sapiens Infant, Newborn Male Pregnancy Pregnancy Complications, Parasitic Pregnancy Trimester, Third Toxoplasmosis, Congenital
9
(33.4%)		 21494173
 Disseminated congenital toxoplasma infection with a type II strain.
Kieffer F, Rigourd V, Ikounga P, Bessieres B, Magny JF, Thulliez P.
Pediatr Infect Dis J. 2011;30(9):813-5.
Purpura Hepatitis
Adult Anti-Infective Agents Antibodies, Protozoan DNA, Protozoan Fatal Outcome Females Genotype Homo sapiens Infant, Newborn Male Pregnancy Pregnancy Complications, Parasitic Toxoplasma Toxoplasmosis, Congenital
10
(33.4%)		 25992942
 An atypical Toxoplasma gondii genotype in a rural Brazilian dog co-infected with Leishmania (Viannia) braziliensis.
Silva RC, Caffaro K, Paula CL, Risseti RM, Langoni H, Megid J, Melanchauski MS, Souza KL, Takahira RK, Machado VM.
Rev Soc Bras Med Trop. 2015;48(2):224-7.
Thrombocytopenia Anemia Hypoalbuminemia
Animals Canis familiaris Coinfection DNA, Protozoan Dog Diseases Females Genotype Leishmania braziliensis Leishmaniasis Polymerase Chain Reaction Toxoplasma Toxoplasmosis, Animal
        

Phenotype(s) retrieved from Orphanet

    Total: 26

HPO ID Term Frequency
HP:0001622 Premature birth Very frequent (99-80%)
HP:0007703 Abnormality of retinal pigmentation Very frequent (99-80%)
HP:0000238 Hydrocephalus Occasional (29-5%)
HP:0000252 Microcephaly Occasional (29-5%)
HP:0000365 Hearing impairment Occasional (29-5%)
HP:0000505 Visual impairment Occasional (29-5%)
HP:0000568 Microphthalmia Occasional (29-5%)
HP:0000639 Nystagmus Occasional (29-5%)
HP:0000952 Jaundice Occasional (29-5%)
HP:0001250 Seizures Occasional (29-5%)
HP:0001252 Muscular hypotonia Occasional (29-5%)
HP:0001263 Global developmental delay Occasional (29-5%)
HP:0001511 Intrauterine growth retardation Occasional (29-5%)
HP:0001531 Failure to thrive in infancy Occasional (29-5%)
HP:0001541 Ascites Occasional (29-5%)
HP:0001640 Cardiomegaly Occasional (29-5%)
HP:0001873 Thrombocytopenia Occasional (29-5%)
HP:0001903 Anemia Occasional (29-5%)
HP:0002014 Diarrhea Occasional (29-5%)
HP:0002119 Ventriculomegaly Occasional (29-5%)
HP:0002240 Hepatomegaly Occasional (29-5%)
HP:0002514 Cerebral calcification Occasional (29-5%)
HP:0002716 Lymphadenopathy Occasional (29-5%)
HP:0002910 Elevated hepatic transaminase Occasional (29-5%)
HP:0012733 Macule Occasional (29-5%)
HP:0100543 Cognitive impairment Occasional (29-5%)


Phenotype(s) retrieved from case reports

    Total: 65

HPO ID Term # of case reports
HP:0012424 Chorioretinitis 10
HP:0000238 Hydrocephalus 5
HP:0007777 Chorioretinal scar 3
HP:0000252 Microcephaly 2
HP:0000618 Blindness 2
HP:0000639 Nystagmus 2
HP:0000952 Jaundice 2
HP:0001945 Fever 2
HP:0003470 Paralysis 2
HP:0012486 Myelitis 2
HP:0031273 Shock 2
HP:0200056 Macular scar 2
HP:0000099 Glomerulonephritis 1
HP:0000100 Nephrotic syndrome 1
HP:0000103 Polyuria 1
HP:0000112 Nephropathy 1
HP:0000135 Hypogonadism 1
HP:0000141 Amenorrhea 1
HP:0000518 Cataract 1
HP:0000528 Anophthalmia 1
HP:0000541 Retinal detachment 1
HP:0000819 Diabetes mellitus 1
HP:0000821 Hypothyroidism 1
HP:0000822 Hypertension 1
HP:0000830 Anterior hypopituitarism 1
HP:0000988 Skin rash 1
HP:0001028 Hemangioma 1
HP:0001075 Atrophic scars 1
HP:0001116 Macular coloboma 1
HP:0001250 Seizures 1
HP:0001287 Meningitis 1
HP:0001396 Cholestasis 1
HP:0001433 Hepatosplenomegaly 1
HP:0001541 Ascites 1
HP:0001876 Pancytopenia 1
HP:0001880 Eosinophilia 1
HP:0002027 Abdominal pain 1
HP:0002240 Hepatomegaly 1
HP:0002273 Tetraparesis 1
HP:0002514 Cerebral calcification 1
HP:0002527 Falls 1
HP:0002617 Dilatation 1
HP:0002716 Lymphadenopathy 1
HP:0002721 Immunodeficiency 1
HP:0002791 Hypoventilation 1
HP:0002835 Aspiration 1
HP:0002907 Microscopic hematuria 1
HP:0003228 Hypernatremia 1
HP:0004749 Atrial flutter 1
HP:0005912 Biliary atresia 1
HP:0006559 Hepatic calcification 1
HP:0008677 Congenital nephrotic syndrome 1
HP:0011477 Upbeat nystagmus 1
HP:0011886 Hyphema 1
HP:0012032 Lipoma 1
HP:0012115 Hepatitis 1
HP:0012521 Optic nerve aplasia 1
HP:0012819 Myocarditis 1
HP:0025582 Submacular hemorrhage 1
HP:0025615 Abscess 1
HP:0031035 Chronic infection 1
HP:0032118 Retinitis 1
HP:0040075 Hypopituitarism 1
HP:0100021 Cerebral palsy 1
HP:0100699 Scarring 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID