Adenohypophysitis

A rare, acquired pituitary hormone deficiency, a type of primary hypophysitis characterized by an inflammation of anterior pituitary. Clinical presentation is variable and includes headaches, visual disturbances, symptoms of adrenal insufficiency, hyperprolactinemia, hypothyroidism and hypogonadism. It most commonly affects young women during pregnancy or postpartum period.

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Narrow down the case reports

Total: 54 (papers)

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Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (17.5%)	7951579	Severe depression associated with ACTH, PRL, and GH deficiency: a case report. Kawai K, Tamai H, Nishikata H, Kobayashi N, Matsubayashi S. Endocr J. 1994;41(3):275-9. [ Show abstract ] [ Hide abstract ]
		Muscle weakness
		CRH GHRH POMC TRH

		Growth Hormone Homo sapiens Male
2 (4.0%)	29796053	Ipilimumab-induced Adenohypophysitis and Orbital Apex Syndrome: Importance of Early Diagnosis and Management. Hassanzadeh B, DeSanto J, Kattah JC. Neuroophthalmology. 2018;42(3):176-181. [ Show abstract ] [ Hide abstract ]
		Proptosis



2 (4.0%)	29220526 (5800826)	Anti-PD-L1 Treatment Induced Central Diabetes Insipidus. Zhao C, Tella SH, Del Rivero J, Kommalapati A, Ebenuwa I, Gulley J, Strauss J, Brownell I. J Clin Endocrinol Metab. 2018;103(2):365-369. [ Show abstract ] [ Hide abstract ]
		Nocturia


		Antibodies, Monoclonal, Humanized Antigens, CD274 Central Diabetes Insipidus Homo sapiens Immunotherapy Male Monoclonal Antibodies Remission Induction
2 (4.0%)	28691978	Occam's Razor Could Not Cut It: Tale of 2 Headaches in a Postpartum Patient: A Case Report. Dolak JA, Hadjipanayis CG, Demma LJ. A A Case Rep. 2017;9(8):233-235. [ Show abstract ] [ Hide abstract ]
		Headache


		Adult Autoimmune Hypophysitis Blood Patch, Epidural Females Headache Homo sapiens Postpartum Period
2 (4.0%)	28202834	[A Case of Lymphocytic Adenohypophysitis Presenting Visual Disturbance in the Third Trimester of Pregnancy]. Yaoita R, Ito M, Matsuda K, Kokubo Y, Sato S, Sonoda Y. No Shinkei Geka. 2017;45(2):161-165. [ Show abstract ] [ Hide abstract ]
		Hypopituitarism


		Adult Autoimmune Hypophysitis Females Homo sapiens Magnetic Resonance Imaging Pituitary Diseases Pregnancy Pregnancy Complications Pregnancy Trimester, Third
2 (4.0%)	26786534	Post-partum hypoglycemia and hypothermia as first manifestations of lymphocytic adenohypophysitis: A case report. Koyama S, Okuno K, Naoi H, Watanabe M, Ozaki K, Shiki Y. J Obstet Gynaecol Res. 2016;42(4):467-70. [ Show abstract ] [ Hide abstract ]
		Hypothyroidism


		Adult Autoimmune Hypophysitis Females Gestational Age Homo sapiens Hypoglycemia Hypothyroidism Magnetic Resonance Imaging Parity Pregnancy Puerperal Disorders
2 (4.0%)	23885185 (3699490)	Lymphocytic panhypophysitis: its clinical features in Japanese cases. Wada Y, Hamamoto Y, Nakamura Y, Honjo S, Kawasaki Y, Ikeda H, Takahashi J, Yuba Y, Shimatsu A, Koshiyama H. Jpn Clin Med. 2011;2:15-20. [ Show abstract ] [ Hide abstract ]
		Polyuria



2 (4.0%)	23238905	Variant of lymphocytic infundibulo-neurohypophysitis presenting with unique clinical and radiological features. Seki T, Yasuda A, Yamaoka T, Imai J, Ito K, Ozawa H, Fukagawa M, Okamatsu C, Nakamura N, Atsumi H, Matsumae M, Takagi A. Tokai J Exp Clin Med. 2012;37(4):126-32. [ Show abstract ] [ Hide abstract ]
		Diabetes insipidus


		Central Diabetes Insipidus Differential Diagnosis Females Homo sapiens Lymphocytosis Magnetic Resonance Imaging Pituitary Diseases Pituitary Gland, Posterior
2 (4.0%)	22443503	Novel strategy to treat a case of recurrent lymphocytic hypophysitis using rituximab. Schreckinger M, Francis T, Rajah G, Jagannathan J, Guthikonda M, Mittal S. J Neurosurg. 2012;116(6):1318-23. [ Show abstract ] [ Hide abstract ]
		Progressive visual loss


		Adult Antibodies, Monoclonal, Murine-Derived Autoimmune Diseases B-Lymphocytes Biopsy Females Homo sapiens Immunologic Factors Lymphocytosis Pituitary Diseases Visual Acuity
2 (4.0%)	21392780	Sudden death in a dog with lymphoplasmacytic hypophysitis. Wolfesberger B, Fuchs-Baumgartinger A, Schwendenwein I, Zeugswetter F, Shibly S. J Comp Pathol. 2011;145(2-3):231-4. [ Show abstract ] [ Hide abstract ]
		Weight loss


		Adrenal Cortex Diseases Animals Canis familiaris Females Pituitary Diseases

Phenotype(s) retrieved from Orphanet

Total: 32

HPO ID	Term	Frequency
HP:0000871	Panhypopituitarism	Very frequent (99-80%)
HP:0000141	Amenorrhea	Frequent (79-30%)
HP:0000622	Blurred vision	Frequent (79-30%)
HP:0000802	Impotence	Frequent (79-30%)
HP:0000870	Prolactin excess	Frequent (79-30%)
HP:0000980	Pallor	Frequent (79-30%)
HP:0001278	Orthostatic hypotension	Frequent (79-30%)
HP:0001895	Normochromic anemia	Frequent (79-30%)
HP:0002018	Nausea	Frequent (79-30%)
HP:0002315	Headache	Frequent (79-30%)
HP:0003158	Hyposthenuria	Frequent (79-30%)
HP:0007987	Progressive visual field defects	Frequent (79-30%)
HP:0008163	Decreased circulating cortisol level	Frequent (79-30%)
HP:0008213	Gonadotropin deficiency	Frequent (79-30%)
HP:0008214	Decreased serum estradiol	Frequent (79-30%)
HP:0008230	obsolete Decreased testosterone in males	Frequent (79-30%)
HP:0008240	Secondary growth hormone deficiency	Frequent (79-30%)
HP:0008245	Pituitary hypothyroidism	Frequent (79-30%)
HP:0011735	Adrenocorticotropin deficient adrenal insufficiency	Frequent (79-30%)
HP:0011748	Adrenocorticotropic hormone deficiency	Frequent (79-30%)
HP:0012504	Abnormal size of pituitary gland	Frequent (79-30%)
HP:0012696	Abnormal thalamic MRI signal intensity	Frequent (79-30%)
HP:0030018	Decreased female libido	Frequent (79-30%)
HP:0040306	Decreased male libido	Frequent (79-30%)
HP:0000407	Sensorineural hearing impairment	Occasional (29-5%)
HP:0000651	Diplopia	Occasional (29-5%)
HP:0000872	Hashimoto thyroiditis	Occasional (29-5%)
HP:0002902	Hyponatremia	Occasional (29-5%)
HP:0003493	Antinuclear antibody positivity	Occasional (29-5%)
HP:0004396	Poor appetite	Occasional (29-5%)
HP:0007041	Chronic lymphocytic meningitis	Occasional (29-5%)
HP:0008202	Prolactin deficiency	Occasional (29-5%)

Phenotype(s) retrieved from case reports

Total: 13

HPO ID	Term	# of case reports
HP:0040075	Hypopituitarism	10
HP:0000873	Diabetes insipidus	2
HP:0002315	Headache	2
HP:0100646	Thyroiditis	2
HP:0000789	Infertility	1
HP:0001123	Visual field defect	1
HP:0001943	Hypoglycemia	1
HP:0002045	Hypothermia	1
HP:0012505	Enlarged pituitary gland	1
HP:0025615	Abscess	1
HP:0032252	Granuloma	1
HP:0100653	Optic neuritis	1
HP:0100829	Galactorrhea	1

Causative gene(s) retrieved from Orphanet

Total: 0

Gene Symbol	Gene Name	Entrez Gene ID