Panhypophysitis

Panhypophysitis is a rare, acquired pituitary hormone deficiency, a type of primary hypophysitis characterized by an inflammation of the entire pituitary gland. Common clinical presentation is diabetes insipidus with polyuria and polydipsia and partial or panhypopituitarism. Other symptoms may include headaches, nausea/vomiting, visual disturbances and fatigue.



Input patient's signs and symptoms


Narrow down the case reports



Total: 11 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
1
(21.2%)
17273922
Lymphocytic panhypophysitis in a young man with involvement of the cavernous sinus and clivus.
Kartal I, Yarman S, Tanakol R, Bilgic B.
Pituitary. 2007;10(1):75-80.
Polyuria Osteopetrosis
Adult Autoimmune Diseases Central Diabetes Insipidus Homo sapiens Hypopituitarism Lymphocytosis Male
2
(4.0%)
28745808
(5598883)
Hypophysitis, Panhypopituitarism, and Hypothalamitis in a Scottish Terrier Dog.
Polledo L, Oliveira M, Adamany J, Graham P, Baiker K.
J Vet Intern Med. 2017;31(5):1527-1532.
Lethargy
Animals Canis familiaris Dog Diseases Hypophysitis Hypopituitarism Hypothalamic Diseases Magnetic Resonance Imaging Male Neuroimaging
2
(4.0%)
27008424
An Atypical Case of Lymphocytic Panhypophysitis in a Pregnant Woman.
Davies EC, Jakobiec FA, Stagner AM, Rizzo JF 3rd.
J Neuroophthalmol. 2016;36(3):313-6.
Headache
Adult Autoimmune Hypophysitis Biopsy Differential Diagnosis Females Homo sapiens Magnetic Resonance Imaging Pituitary Gland Pregnancy Pregnancy Complications Pregnancy Trimester, Third Scotoma Visual Fields
2
(4.0%)
26313211
Adrenal insufficiency secondary to lymphocytic panhypophysitis in a cat.
Rudinsky AJ, Clark ES, Russell DS, Gilor C.
Aust Vet J. 2015;93(9):327-31.
Polyuria
Adrenal Glands Animals Autoimmune Hypophysitis Cat Diseases Felis catus Male
2
(4.0%)
23885185
(3699490)
Lymphocytic panhypophysitis: its clinical features in Japanese cases.
Wada Y, Hamamoto Y, Nakamura Y, Honjo S, Kawasaki Y, Ikeda H, Takahashi J, Yuba Y, Shimatsu A, Koshiyama H.
Jpn Clin Med. 2011;2:15-20.
Polyuria
2
(4.0%)
23238905
Variant of lymphocytic infundibulo-neurohypophysitis presenting with unique clinical and radiological features.
Seki T, Yasuda A, Yamaoka T, Imai J, Ito K, Ozawa H, Fukagawa M, Okamatsu C, Nakamura N, Atsumi H, Matsumae M, Takagi A.
Tokai J Exp Clin Med. 2012;37(4):126-32.
Diabetes insipidus
Central Diabetes Insipidus Differential Diagnosis Females Homo sapiens Lymphocytosis Magnetic Resonance Imaging Pituitary Diseases Pituitary Gland, Posterior
2
(4.0%)
21387696
[A case of optic neuritis associated with lymphocytic hypophysitis revealed by pattern-reversal VEP].
Saito S, Mori C, Toma K, Kubori T, Nishinaka K, Udaka F.
Rinsho Shinkeigaku. 2011;51(1):27-31.
Hypogonadism
OAS3
Adult Homo sapiens Lymphocyte Male Optic Neuritis Pituitary Diseases
2
(4.0%)
18987830
Lymphocytic infundibulo-neurohypophysitis and infundibulo-panhypophysitis regarded as lymphocytic hypophysitis variant.
Abe T.
Brain Tumor Pathol. 2008;25(2):59-66.
Diabetes insipidus
Adult Central Diabetes Insipidus Differential Diagnosis Females Homo sapiens Lymphocytosis Male Middle Aged Pituitary Diseases Pituitary Gland, Posterior
2
(4.0%)
17992609
A case of lymphocytic panhypophysitis (LPH) during pregnancy.
Arai Y, Nabe K, Ikeda H, Honjo S, Wada Y, Hamamoto Y, Nomura K, Aoki T, Sano T, Koshiyama H.
Endocrine. 2007;32(1):117-21.
Visual field defect
POMC PRL
Adult Females Headache Homo sapiens Lymphocytosis Pituitary Diseases Pregnancy Pregnancy Complications Pregnancy Trimester, First Pregnancy Trimester, Second Vision Disorders
2
(4.0%)
17317948
Granulomatous pachymeningitis around the sella turcica (Tolosa-Hunt syndrome) involving the hypophysis--case report.
Kita D, Tachibana O, Nagai Y, Sano H, Yamashita J.
Neurol Med Chir (Tokyo). 2007;47(2):85-8.
Diplopia
Females Homo sapiens Hypopituitarism Middle Aged Tolosa-Hunt Syndrome
        

Phenotype(s) retrieved from Orphanet

    Total: 35

HPO ID Term Frequency
HP:0000863 Central diabetes insipidus Very frequent (99-80%)
HP:0000871 Panhypopituitarism Very frequent (99-80%)
HP:0011751 Abnormality of the posterior pituitary Very frequent (99-80%)
HP:0000141 Amenorrhea Frequent (79-30%)
HP:0000622 Blurred vision Frequent (79-30%)
HP:0000802 Impotence Frequent (79-30%)
HP:0000870 Prolactin excess Frequent (79-30%)
HP:0000980 Pallor Frequent (79-30%)
HP:0001278 Orthostatic hypotension Frequent (79-30%)
HP:0001895 Normochromic anemia Frequent (79-30%)
HP:0001959 Polydipsia Frequent (79-30%)
HP:0002018 Nausea Frequent (79-30%)
HP:0002315 Headache Frequent (79-30%)
HP:0003158 Hyposthenuria Frequent (79-30%)
HP:0007987 Progressive visual field defects Frequent (79-30%)
HP:0008163 Decreased circulating cortisol level Frequent (79-30%)
HP:0008213 Gonadotropin deficiency Frequent (79-30%)
HP:0008214 Decreased serum estradiol Frequent (79-30%)
HP:0008230 obsolete Decreased testosterone in males Frequent (79-30%)
HP:0008240 Secondary growth hormone deficiency Frequent (79-30%)
HP:0008245 Pituitary hypothyroidism Frequent (79-30%)
HP:0011735 Adrenocorticotropin deficient adrenal insufficiency Frequent (79-30%)
HP:0011748 Adrenocorticotropic hormone deficiency Frequent (79-30%)
HP:0012504 Abnormal size of pituitary gland Frequent (79-30%)
HP:0012696 Abnormal thalamic MRI signal intensity Frequent (79-30%)
HP:0030018 Decreased female libido Frequent (79-30%)
HP:0040306 Decreased male libido Frequent (79-30%)
HP:0000407 Sensorineural hearing impairment Occasional (29-5%)
HP:0000651 Diplopia Occasional (29-5%)
HP:0000872 Hashimoto thyroiditis Occasional (29-5%)
HP:0002902 Hyponatremia Occasional (29-5%)
HP:0003493 Antinuclear antibody positivity Occasional (29-5%)
HP:0004396 Poor appetite Occasional (29-5%)
HP:0007041 Chronic lymphocytic meningitis Occasional (29-5%)
HP:0008202 Prolactin deficiency Occasional (29-5%)


Phenotype(s) retrieved from case reports

    Total: 3

HPO ID Term # of case reports
HP:0000846 Adrenal insufficiency 1
HP:0000873 Diabetes insipidus 1
HP:0002315 Headache 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID