Hydrops fetalis

Hydrops fetalis is a severe and challenging fetal condition usually defined as the excessive accumulation of fetal fluid within the fetal extravascular compartments and body cavities that manifests as edema, pleural and pericardial effusion and ascites. It is the end-stage of a wide variety of disorders. The cause may be immunologic (immune hydrops fetalis, IHF) or non immunologic (non-immune hydrops fetalis, NIHF), depending on the presence or absence of maternal antibodies against fetal red cell antigens (ABO incompatibility or rhesus (Rh) incompatibility).

Hemolytic anemia

A type of anemia caused by premature destruction of red blood cells (hemolysis).


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PMID (PMCID)
26578498
 FEMALE Adult
Prenatal diagnosis of Klippel-Trenaunay-Weber syndrome with Kasabach-Merritt syndrome in utero.
Tanaka K, Miyazaki N, Matsushima M, Yagishita R, Izawa T, Tanigaki S, Sakai K, Iwashita M.
J Med Ultrason (2001). 2015;42(1):109-12.
We believe the fetus's condition was complicated with Kasabach-Merritt syndrome in utero, which caused acute hemolytic anemia leading to high-output cardiac failure and fetal hydrops.
24262303
 MIXED_SAMPLE Infant, Newborn
Hemolytic disease of the fetus and newborn with late-onset anemia due to anti-M: a case report and review of the Japanese literature.
Yasuda H, Ohto H, Nollet KE, Kawabata K, Saito S, Yagi Y, Negishi Y, Ishida A.
Transfus Med Rev. 2014;28(1):1-6.
In the Japanese population, 21 of 34 cases of M/N-incompatible HDFN (72%) have manifested as severe hemolytic anemia and/or hydrops fetalis.
24262303
 MIXED_SAMPLE Infant, Newborn
Hemolytic disease of the fetus and newborn with late-onset anemia due to anti-M: a case report and review of the Japanese literature.
Yasuda H, Ohto H, Nollet KE, Kawabata K, Saito S, Yagi Y, Negishi Y, Ishida A.
Transfus Med Rev. 2014;28(1):1-6.
Twenty-one of 29 survivors (72%) had severe hemolytic anemia and/or hydrops fetalis.
25322544
 FEMALE
[Maternal blood intrauterine transfusions in the therapy of red-cell alloimmunization performed in three difficult cases].
Kucinska-Chahwan A, Massalska D, Bijok J, Rudzinska M, Kopec I, Rzymkiewicz L, Jakiel G, Roszkowski T.
Ginekol Pol. 2014;85(9):703-7.
Maternal alloimmunization can lead to hemolytic anemia, hydrops fetalis and even fetal or neonatal death.
18841022
 MIXED_SAMPLE Infant, Newborn
Hydrops fetalis caused by homozygous alpha-thalassemia and Kidd antigen alloimmunization in a Chinese woman.
Li DZ, Zhong HZ, Li J, Liao C.
Fetal Diagn Ther. 2008;24(4):331-3.
We report a case with hydrops fetalis resulting from homozygous alpha-thalassemia and alloimmune hemolytic anemia due to anti-JK3.
15224363
 MIXED_SAMPLE Infant, Newborn
Hydrops fetalis associated with homozygosity for hemoglobin Taybe (alpha 38/39 THR deletion) in newborn triplets.
Arnon S, Tamary H, Dgany O, Litmanovitz I, Regev R, Bauer S, Dolfin T, Yacobovich J, Wolach B, Jaber L.
Am J Hematol. 2004;76(3):263-6.
All three infants developed intrauterine hemolytic anemia, which subsequently led to hydrops fetalis.
15931362
 MIXED_SAMPLE Infant, Newborn
Hydrops fetalis caused by homozygous alpha-thalassemia and Rh antigen alloimmunization: report of a survivor and literature review.
Joshi DD, Nickerson HJ, McManus MJ.
Clin Med Res. 2004;2(4):228-32.
We report the case of a boy with hydrops fetalis who had homozygous alpha-thalassemia and alloimmune hemolytic anemia due to anti-E and anti-C blood group antibodies.
15931362
 MIXED_SAMPLE Infant, Newborn
Hydrops fetalis caused by homozygous alpha-thalassemia and Rh antigen alloimmunization: report of a survivor and literature review.
Joshi DD, Nickerson HJ, McManus MJ.
Clin Med Res. 2004;2(4):228-32.
Hematologic causes of hydrops fetalis include homozygous alpha-thalassemia and immune hemolytic anemias.
9005995
 MIXED_SAMPLE
Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.
Gallagher PG, Petruzzi MJ, Weed SA, Zhang Z, Marchesi SL, Mohandas N, Morrow JS, Forget BG.
J Clin Invest. 1997;99(2):267-77.
He has remained transfusion-dependent for more than 2 yr. A previous sibling born with hemolytic anemia and hydrops fetalis died on the second day of life.
9005995
 MIXED_SAMPLE
Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.
Gallagher PG, Petruzzi MJ, Weed SA, Zhang Z, Marchesi SL, Mohandas N, Morrow JS, Forget BG.
J Clin Invest. 1997;99(2):267-77.
We studied an infant with severe nonimmune hemolytic anemia and hydrops fetalis at birth.