Aspergillosis

A rare infectious disease caused by inhalation of the opportunistic fungus <i>aspergillus</i> that can lead to the following manifestations: allergic bronchopulmonary aspergillosis (ABPA), aspergilloma, chronic necrotizing pulmonary aspergillosis (CNPA), and invasive aspergillosis (IA). Aspergilloma occurs in patients with cavitary lung disease and results in a fungal mass with variable clinical presentations from asymptomatic to life-threatening (massive hemoptysis). CNPA manifests as subacute pneumonia in patients with underlying disease. IA is disseminated aspergillosis that eventually invades other organs. Cutaneous aspergillosis is usually the dermatological manifestation of IA that manifests as erythematous-to-violaceous plaques or papules, often characterized by a central necrotic ulcer or eschar.

Rheumatoid arthritis

Inflammatory changes in the synovial membranes and articular structures with widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, as well as atrophy and rarefaction of bony structures.


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(per page)
PMID (PMCID)
30930349
 MALE Middle Aged
Chronic Nodular Pulmonary Aspergillosis in a Patient with Rheumatoid Arthritis.
Ito Y, Tanigawa M, Takemura T, Iwamoto K, Nigi A, Sasano H, Itani H, Kondo S, Tokui T, Nakamura S, Miyazaki Y.
Intern Med. 2019;58(7):979-984.
We herein report a case of slowly progressing chronic multiple nodular pulmonary aspergillosis in a 59-year-old man with rheumatoid arthritis, dyspnea, and fatigue.
30930349
 MALE Middle Aged
Chronic Nodular Pulmonary Aspergillosis in a Patient with Rheumatoid Arthritis.
Ito Y, Tanigawa M, Takemura T, Iwamoto K, Nigi A, Sasano H, Itani H, Kondo S, Tokui T, Nakamura S, Miyazaki Y.
Intern Med. 2019;58(7):979-984.
Chronic Nodular Pulmonary Aspergillosis in a Patient with Rheumatoid Arthritis.
20522855
 FEMALE Adult
The use of abatacept in debilitating cavitating lung disease associated with rheumatoid arthritis, bronchocentric granulomatosis and aspergillosis.
Neff K, Stack J, Harney S, Henry M.
Thorax. 2010;65(6):545-6.
The use of abatacept in debilitating cavitating lung disease associated with rheumatoid arthritis, bronchocentric granulomatosis and aspergillosis.
15782314
 MIXED_SAMPLE Middle Aged
Cerebral aspergillosis in the critically ill: two cases of successful medical treatment.
Ehrmann S, Bastides F, Gissot V, Mercier E, Magro P, Bailly E, Legras A.
Intensive Care Med. 2005;31(5):738-42.
The first patient was a 49-year-old man with rheumatoid arthritis who received corticosteroid and cyclophosphamide treatment and developed pulmonary and cerebral invasive aspergillosis.
14600805
 FEMALE Middle Aged
Disseminated tuberculosis, pulmonary aspergillosis and cutaneous herpes simplex infection in a patient with infliximab and methotrexate.
van der Klooster JM, Bosman RJ, Oudemans-van Straaten HM, van der Spoel JI, Wester JPJ, Zandstra DF.
Intensive Care Med. 2003;29(12):2327-2329.
Despite chemoprophylaxis with isoniazid a 58-year-old Creole patient with mild rheumatoid arthritis developed disseminated tuberculosis, pulmonary aspergillosis and cutaneous herpes simplex infection during treatment with infliximab and methotrexate.
8032050
 MALE
Invasive pulmonary aspergillosis associated with low dose methotrexate therapy for rheumatoid arthritis: a case report of treatment with itraconazole.
O'Reilly S, Hartley P, Jeffers M, Casey E, Clancy L.
Tuber Lung Dis. 1994;75(2):153-5.
Invasive pulmonary aspergillosis associated with low dose methotrexate therapy for rheumatoid arthritis: a case report of treatment with itraconazole.
8032050
 MALE
Invasive pulmonary aspergillosis associated with low dose methotrexate therapy for rheumatoid arthritis: a case report of treatment with itraconazole.
O'Reilly S, Hartley P, Jeffers M, Casey E, Clancy L.
Tuber Lung Dis. 1994;75(2):153-5.
We report a case of invasive pulmonary aspergillosis which developed in a patient being treated for seropositive rheumatoid arthritis with low dose methotrexate (5-7.5 mg weekly) for 8 years.
8377390
 MIXED_SAMPLE Adult
[Ocular manifestations of rheumatic diseases. Cooperation between internist/ophthalmologist].
Tyndall A, Steiger U.
Klin Monbl Augenheilkd. 1993;202(5):352-5.
Scleritis may be seen with connective tissue diseases or auto immune conditions (rheumatoid arthritis, Wegener granulomatosis, polyarteritis nodosa, relapsing polychondritis, SLE), infections (herpes, tuberculosis, syphilis, aspergillosis) or metabolic (gout, porphyria, cystinosis).