Aspergillosis

A rare infectious disease caused by inhalation of the opportunistic fungus <i>aspergillus</i> that can lead to the following manifestations: allergic bronchopulmonary aspergillosis (ABPA), aspergilloma, chronic necrotizing pulmonary aspergillosis (CNPA), and invasive aspergillosis (IA). Aspergilloma occurs in patients with cavitary lung disease and results in a fungal mass with variable clinical presentations from asymptomatic to life-threatening (massive hemoptysis). CNPA manifests as subacute pneumonia in patients with underlying disease. IA is disseminated aspergillosis that eventually invades other organs. Cutaneous aspergillosis is usually the dermatological manifestation of IA that manifests as erythematous-to-violaceous plaques or papules, often characterized by a central necrotic ulcer or eschar.

Neutropenia

An abnormally low number of neutrophils in the peripheral blood.

Total: 63

(per page)

PMID (PMCID)
30700454	MIXED_SAMPLE	Middle Aged
	Invasive aspergillosis complicating treatment with tyrosine kinase inhibitors.
	Nasir T, Lee C, Lawrence AS, Brown JS. BMJ Case Rep. 2019;12(1):.
	We describe three cases of pulmonary aspergillosis (PA) in three patients without traditional risk factors for invasive aspergillosis infection, such as prolonged neutropenia or high dose systemic corticosteroid therapy.
30700454	MIXED_SAMPLE	Middle Aged
	Invasive aspergillosis complicating treatment with tyrosine kinase inhibitors.
	Nasir T, Lee C, Lawrence AS, Brown JS. BMJ Case Rep. 2019;12(1):.
	We describe three cases of pulmonary aspergillosis (PA) in three patients without traditional risk factors for invasive aspergillosis infection, such as prolonged neutropenia or high dose systemic corticosteroid therapy.
29790292	OTHER
	Failure of voriconazole therapy due to acquired azole resistance in Aspergillus fumigatus in a kidney transplant recipient with chronic necrotizing aspergillosis.
	Pilmis B, Garcia-Hermoso D, Alanio A, Catherinot E, Scemla A, Jullien V, Bretagne S, Lortholary O. Am J Transplant. 2018;18(9):2352-2355.
	Invasive aspergillosis (IA) affects the lungs and disseminates mostly in patients with neutropenia and/or patients who are receiving immunosuppressive and steroid therapies.
30555119	MALE
	Fatal Invasive Pulmonary Aspergillosis Associated with Nonspecific Interstitial Pneumonia: An Autopsy Case Report.
	Matsuyama H, Miyoshi S, Sugino K, Ota H, Toyoda Y, Nihonyanagi Y, Shibuya K, Homma S. Intern Med. 2018;57(24):3619-3624.
	Invasive pulmonary aspergillosis (IPA) usually occurs in patients with severe immunodeficiencies involving neutropenia.
29357049	MALE	Adult
	Multiple small bowel perforations due to invasive aspergillosis in a patient with acute myeloid leukemia: case report and a systematic review of the literature.
	Di Franco G, Tagliaferri E, Pieroni E, Benedetti E, Guadagni S, Palmeri M, Furbetta N, Campani D, Di Candio G, Petrini M, Mosca F, Morelli L. Infection. 2018;46(3):317-324.
	A 43-year-old man with acute myeloid leukemia under chemotherapy developed severe neutropenia and pulmonary aspergillosis due to Aspergillus flavus.
29357049	MALE	Adult
	Multiple small bowel perforations due to invasive aspergillosis in a patient with acute myeloid leukemia: case report and a systematic review of the literature.
	Di Franco G, Tagliaferri E, Pieroni E, Benedetti E, Guadagni S, Palmeri M, Furbetta N, Campani D, Di Candio G, Petrini M, Mosca F, Morelli L. Infection. 2018;46(3):317-324.
	Gastrointestinal aspergillosis should be suspected in patients with severe and prolonged neutropenia with or without pulmonary involvement in order to consider the right therapy and prompt surgery.
29283878	MALE	Young Adult
	Occupational CNS aspergillosis in an immunocompetent individual a diagnostic challange.
	Punia P, Goel N, Singh I, Chaudhary U. Arch Environ Occup Health. 2018;73(6):381-384.
	Invasive aspergillosis (IA) occurs in patients with risk factors including prolonged neutropenia, neutrophil dysfunction, patient on cytotoxic drugs, steroid therapy, hematological malignancy, AIDS or in patients with bone marrow transplantation.
30613674	OTHER
	Renal aspergillosis in a liver transplant patient: A case report and review of literature.
	Smolovic B, Vukcevic B, Muhovic D, Ratkovic M. World J Clin Cases. 2018;6(16):1155-1159.
	Significant risk factors for invasive aspergillosis in liver recipients include corticosteroid therapy, neutropenia, T-cell dysfunction, renal failure and requirement for renal replacement therapy.
29453853	MIXED_SAMPLE	Adult
	Role of bi-weekly serum galactomannan screening for the diagnosis of invasive aspergillosis in haematological cancer patients.
	Couchepin J, Brunel AS, Jaton K, Meylan P, Bochud PY, Lamoth F. Mycoses. 2018;61(6):350-354.
	Invasive aspergillosis (IA) is a life-threatening infection affecting haematological cancer patients with chemotherapy-induced neutropenia.
29281994 (5745601)	MALE	Middle Aged
	Successful treatment of cerebral aspergillosis: case report of a patient with T-cell large granular lymphocytic leukemia (T-LGL).
	Turki AT, Rashidi-Alavijeh J, Durig J, Gerken G, Rath PM, Witzke O. BMC Infect Dis. 2017;17(1):797.
	Invasive aspergillosis involving patients with neutropenia or severe immunosuppression, such as patients with hematologic malignancies is associated with high mortality.
26879169 (4770625)	OTHER
	Pulmonary aspergillosis diagnosed by endoscopic ultrasound fine-needle aspiration.
	Rodrigues-Pinto E, Lopes S, Principe F, Costa J, Macedo G. Endosc Ultrasound. 2016;5(1):58-60.
	Pulmonary aspergillosis generally occurs in patients with prolonged neutropenia or immunosupression.
26894041 (4757915)	OTHER
	Conidial heads (Fruiting Bodies) as a hallmark for histopathological diagnosis of angioinvasive aspergillosis.
	Lanzarin LD, Mariano LC, Macedo MC, Batista MV, Duarte AN Sr. Autops Case Rep. 2015;5(4):9-18.
	The post-transplantation period was troublesome with the development of severe neutropenia, human respiratory syncytial virus pneumonia, and disseminated aspergillosis, which was suspected because of a positive serum galactomannan antigen determination, and resulted in a fatal outcome.
24878914	FEMALE	Middle Aged
	[Esophageal aspergillosis in a patient with acute myelogenous leukemia and febrile neutropenia].
	Besa S, Kattan E, Cid X, Claro JC. Rev Chilena Infectol. 2014;31(2):222-3.
	[Esophageal aspergillosis in a patient with acute myelogenous leukemia and febrile neutropenia].
22697382	MALE	Middle Aged
	47 year-old man with HIV infection and hemiplegia.
	Gonzalez-Duarte A, Saniger M, Arispe-Angulo K, Gamboa-Dominguez A, Garcia-Ramos G. Brain Pathol. 2012;22(4):567-70.
	CNS aspergillosis is often missed in the setting of advanced HIV infection, especially in the absence of presumed risk factors such as neutropenia or prior steroid treatment.
23326111 (3543560)	OTHER
	Complete heart block in a neutropenic patient with aspergillosis: An unusual adverse effect of caspofungins.
	Biswal S. J Pharmacol Pharmacother. 2012;3(4):342-4.
	Subsequent to induction chemotherapy the patient developed invasive pulmonary aspergillosis with sudden tachypnea, dyspnoea, fever, bilateral pulmonary infiltrates and acute respiratory insufficiency consequent to neutropenia with ANC<500.
22937327 (3420437)	OTHER
	Successful treatment of fanconi anemia and T-cell acute lymphoblastic leukemia.
	Flatt T, Neville K, Lewing K, Dalal J. Case Rep Hematol. 2012;2012:396395.
	He experienced chemotherapy-related complications including prolonged neutropenia, grade IV vincristine neuropathy, and disseminated aspergillosis.
21596908	MALE	Adult
	A rare, fatal case of invasive spinal aspergillosis in an antiretroviral-naive, HIV-infected man with pre-existing lung colonization.
	Rossouw I, Goedhals D, van der Merwe J, Stallenberg V, Govender N. J Med Microbiol. 2011;60(Pt 10):1534-8.
	Invasive aspergillosis should be considered as part of the differential diagnosis among HIV-infected patients with non-specific, focal CNS symptoms, even among those without classical risk factors such as neutropenia, and aggressive antifungal therapy should be instituted as early as possible.
21596908	MALE	Adult
	A rare, fatal case of invasive spinal aspergillosis in an antiretroviral-naive, HIV-infected man with pre-existing lung colonization.
	Rossouw I, Goedhals D, van der Merwe J, Stallenberg V, Govender N. J Med Microbiol. 2011;60(Pt 10):1534-8.
	We report a case of invasive aspergillosis with spinal involvement in a human immunodeficiency virus (HIV)-infected patient without neutropenia.
21311430	MALE
	Complete clinical recovery of a central pontine and extrapontine myelinolysis delayed onset in a child with acute myeloblastic leukemia.
	Yilmaz D, Karapinar B, Balkan C, Ay Y, Kavakli K. Minerva Pediatr. 2011;63(1):61-65.
	A 2.5-year-old child with a diagnosis of acute myeloblastic leukemia developed febril neutropenia, diarrhea, gastrointestinal hemorrhage followed by pulmonary aspergillosis.
20604767	MALE	Middle Aged
	Invasive oral aspergillosis in a patient with acute myeloid leukaemia.
	Cho H, Lee KH, Colquhoun AN, Evans SA. Aust Dent J. 2010;55(2):214-8.
	In such patients, prolonged neutropenia secondary to chemotherapeutic agents enables the spread of invasive aspergillosis, which is unaffected by anatomical barriers.