Bartsocas-Papas syndrome

Bartsocas-Papas syndrome is a rare, inherited, popliteal pterygium syndrome (see this term) characterized by severe popliteal webbing, microcephaly, a typical face with short palpebral fissures, ankyloblepharon, hypoplastic nose, filiform bands between the jaws and facial clefts, oligosyndactyly, genital abnormalities, and additional ectodermal anomalies (i.e. absent hair, eyebrows, lashes, nails). It is often fatal in the neonatal period, but patients living until childhood have been reported.

Popliteal pterygium

A pterygium (or pterygia) occurring in the popliteal region (the back of the knee).

合計: 1

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PMID (PMCID)
22197489	MIXED_SAMPLE	Infant, Newborn
	Mutations in RIPK4 cause the autosomal-recessive form of popliteal pterygium syndrome.
	Kalay E, Sezgin O, Chellappa V, Mutlu M, Morsy H, Kayserili H, Kreiger E, Cansu A, Toraman B, Abdalla EM, Aslan Y, Pillai S, Akarsu NA. Am J Hum Genet. 2012;90(1):76-85.
	The autosomal-recessive form of popliteal pterygium syndrome, also known as Bartsocas-Papas syndrome, is a rare, but frequently lethal disorder characterized by marked popliteal pterygium associated with multiple congenital malformations.