Budd-Chiari syndrome

Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava.

Resistance to activated protein C

Poor anticoagulant response to activated protein C. A plasma is termed 'APC resistant' when the addition of exogenous APC fails to prolong its clotting time in an activated partial thromboplastin time assay.


Total: 5

                       


(per page)
PMID (PMCID)
14697963
 MALE Middle Aged
Liver transplantation in a patient with Budd-Chiari syndrome secondary to factor V Leiden mutation.
Karasu Z, Nart D, Lebe E, Demirbas T, Memis A, Kilic M, Akyildiz M, Tokat Y.
Transplant Proc. 2003;35(8):3008-10.
We suggest checking resistance to activated protein C, rather than PCR analysis of factor V Leiden mutation in patients with Budd-Chiari syndrome after liver transplantation; the presence of the second does not effect clinical outcome.
9774130
 MALE Adult
Budd-Chiari syndrome during nephrotic relapse in a patient with resistance to activated protein C clotting inhibitor.
Gambaro G, Patrassi G, Pittarello F, Nardellotto A, Checchetto S, D'Angelo A.
Am J Kidney Dis. 1998;32(4):657-60.
Budd-Chiari syndrome during nephrotic relapse in a patient with resistance to activated protein C clotting inhibitor.
8889463
 FEMALE Adult
Acute Budd-Chiari syndrome treated by liver transplantation in a woman homozygous for factor V Leiden.
Blanshard C, Pasi J, Rolles K, Davidson B, Jain S, Burroughs A.
Eur J Gastroenterol Hepatol. 1996;8(9):925-7.
We describe the first case of Budd-Chiari syndrome due to homozygosity for factor V Leiden resulting in resistance to activated protein C. This is now recognized as the most common procoagulant disorder, and may account for many cases of Budd-Chiari syndrome previously though to be idiopathic or due to a latent myeloproliferative disorder.
8889463
 FEMALE Adult
Acute Budd-Chiari syndrome treated by liver transplantation in a woman homozygous for factor V Leiden.
Blanshard C, Pasi J, Rolles K, Davidson B, Jain S, Burroughs A.
Eur J Gastroenterol Hepatol. 1996;8(9):925-7.
We describe the first case of Budd-Chiari syndrome due to homozygosity for factor V Leiden resulting in resistance to activated protein C. This is now recognized as the most common procoagulant disorder, and may account for many cases of Budd-Chiari syndrome previously though to be idiopathic or due to a latent myeloproliferative disorder.
8942748
 FEMALE Adult
Acute Budd-Chiari syndrome with fulminant hepatic failure in a pregnant woman with factor V Leiden mutation.
Fickert P, Ramschak H, Kenner L, Hoefler G, Hinterleitner TA, Petritsch W, Klimpfinger M, Krejs GJ, Stauber RE.
Gastroenterology. 1996;111(6):1670-3.
This report presents a case of acute hepatic failure in a 20-year-old pregnant woman attributable to Budd-Chiari syndrome with underlying resistance to activated protein C caused by factor V Leiden mutation.