Chronic beryllium disease

Chronic beryllium disease (CBD) is a granulomatous, interstitial lung disease that occurs in individuals who develop beryllium sensitization (BeS), a cell-mediated immune response to environmental and occupational beryllium exposure. BeS precedes the lung disease that may present with chronic dry cough, fatigue, weight loss, chest pain, and increasing dyspnea.

Granuloma

A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis.


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PMID (PMCID)
29374638
 MALE Middle Aged
Fluctuating hypercalcaemia caused by cavitary Mycobacterium bovis pulmonary infection.
Moloney DP, Chawke L, Crowley MT, O'Connor TM.
BMJ Case Rep. 2018;2018:.
Other causes include berylliosis, coccidioidomycosis, histoplasmosis, Crohn's disease, silicone-induced granulomas, cat-scratch disease, Wegener's granulomatosis and Pneumocystis carinii pneumonia.
25668608
 MALE
[Epitheloid cell granulomas in bronchial invasive mucinous adenocarcinoma].
Grunewaldt A, Wagner TO.
Pneumologie. 2015;69(2):89-92.
Furthermore, granulomas can be caused by foreign body reactions like berylliosis or silicosis as well as by other infections (e.8202g.
18756925
 MALE Adult
Thoracic intramedullary sarcoidosis mimicking an intramedullary tumor.
Beros V, Houra K, Rotim K, Kovac D, Cupic H.
Coll Antropol. 2008;32(2):645-7.
Since other infectious diseases such as berylliosis, mycobacterium and fungal infections may present with a noncaseating granulomas, histological diagnosis of sarcoidosis is made using the elimination method.
17144583
 MALE Middle Aged
[A case of pleural sarcoidosis in which vats lung biopsy, obtained pleural and pulmonary lesions].
Sugino K, Kimura K, Hiroi M, Hata Y, Takagi K, Hasegawa C, Shibuya K, Kohashi Y, Nakata K.
Nihon Kokyuki Gakkai Zasshi. 2006;44(11):838-43.
Histopathologically, several non-caseous epithelioid cell granulomas and silicotic nodule-like lesions of hyaline degeneration were found; therefore, pneumoconiosis, or more specifically chronic berylliosis, was suspected.
11811929
 FEMALE Middle Aged
Chronic beryllium disease: a model interaction between innate and acquired immunity.
Sawyer RT, Maier LA, Kittle LA, Newman LS.
Int Immunopharmacol. 2002;2(2-3):249-61.
Interstitial mononuclear cell inflammation and granuloma formation are the primary processes that occur in the lungs of Be-exposed workers, resulting in chronic beryllium disease (CBD).
8544383
 MALE Adult
[Chronic Beryllium disease after exposure to low-beryllium-content copper].
Hasejima N, Kobayashi H, Takezawa S, Yamato K, Kadoyama C, Kawano Y.
Nihon Kyobu Shikkan Gakkai Zasshi. 1995;33(10):1105-10.
A specimen obtained by open-lung biopsy showed epithelioid cell granuloma and alveolitis, which were compatible with chronic beryllium disease.
2629665
 MALE
[Chronic berylliosis of the lungs].
Blokhin AV.
Arkh Patol. 1989;51(12):52-5.
Sclerotic granulomas with giant cells, conchoidal bodies, iron deposition in the pulmonary stroma--all these lung alterations allowed one to establish a diagnosis of lung berylliosis.