Macular amyloidosis

Macular amyloidosis (MA) is a rare chronic form of cutaneous amyloidosis (see this term), a skin disease characterized by the accumulation of amyloid deposits in the dermis, clinically characterized by pruritic hyperkeratotic gray-brown macules that give a rippled or reticulated pattern of pigmentation usually in the upper back and extensor sites of arms, forearms and legs, and histologically by the deposition of amyloid in the upper dermis and close to the basal cell layer of the epidermis. MA is commonly associated with other skin diseases, such as atopic dermatitis.

Nephropathy

A nonspecific term referring to disease or damage of the kidneys.


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(per page)
PMID (PMCID)
19335432
FEMALE Adult
Primary localized cutaneous amyloidosis: a sign of immune dysregulation?
Dahdah MJ, Kurban M, Kibbi AG, Ghosn S.
Int J Dermatol. 2009;48(4):419-21.
We report a case of sarcoidosis and a case of IgA nephropathy in association with extensive macular amyloidosis, adding these two conditions to the list of other autoimmune/immune disorders associated with PLCA.