Hereditary breast and ovarian cancer syndrome

Breast cancer (BC) is the most common cancer in women, accounting for 25% of all new cases of cancer. Most BC cases are sporadic, while 5-10% are estimated to be due to an inherited predisposition.

Carcinoma

A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus).


Total: 4

                       


(per page)
PMID (PMCID)
29094253
 FEMALE Adult
Peritoneal cancer arising after total abdominal hysterectomy and bilateral salpingo-oophorectomy for cervical cancer in a patient with right breast cancer and germline mutation of BRCA1 gene: a case report and literature review.
Harao M, Ando J, Kamata H, Hoshi N, Igarashi S, Sekiguchi R, Sugano K.
Breast Cancer. 2018;25(2):243-249.
Peritoneal carcinoma can occur in association with hereditary breast and ovarian cancer syndrome, which is thought to account for 5-6% of all breast cancer.
28049106
 FEMALE Middle Aged
Linking uterine serous carcinoma to BRCA1/2-associated cancer syndrome: A meta-analysis and case report.
de Jonge MM, Mooyaart AL, Vreeswijk MP, de Kroon CD, van Wezel T, van Asperen CJ, Smit VT, Dekkers OM, Bosse T.
Eur J Cancer. 2017;72:215-225.
As high-grade ovarian tubal serous carcinoma is known to be associated with BRCA1/2 pathogenic germline mutations (PMs), we aimed to explore whether USC is also a constituent of hereditary breast and ovarian cancer syndrome.
24719479
 FEMALE Middle Aged
Serous tubal intraepithelial carcinoma in a Japanese woman with a deleterious BRCA1 mutation.
Ishikawa H, Kiyokawa T, Utsuno E, Matsushita K, Nomura F, Shozu M.
Jpn J Clin Oncol. 2014;44(6):597-601.
Here, we report the first case of serous tubal intraepithelial carcinoma identified through a risk-reducing salpingo-oophorectomy in a Japanese woman with hereditary breast and ovarian cancer syndrome and who had a deleterious germline mutation of E1214X in BRCA1, but not a BRCA2 mutation.
24719479
 FEMALE Middle Aged
Serous tubal intraepithelial carcinoma in a Japanese woman with a deleterious BRCA1 mutation.
Ishikawa H, Kiyokawa T, Utsuno E, Matsushita K, Nomura F, Shozu M.
Jpn J Clin Oncol. 2014;44(6):597-601.
Our case demonstrated that risk-reducing salpingo-oophorectomy can detect occult cancers, including serous tubal intraepithelial carcinoma, thereby preventing future cancer development in the Japanese hereditary breast and ovarian cancer syndrome population.