Juvenile xanthogranuloma

Juvenile xanthogranuloma is the most common type of non-Langerhans cell histiocytosis (see this term) characterized by the occurrence of one or more reddish or yellowish self-limiting and benign papules or nodules of several millimeters in diameter, usually appearing on the head and neck (but sometimes on the extremities and trunk) during the first year of life (or rarely in adulthood) and usually regressing spontaneously. Extracutaneous involvement has also been reported, involving most commonly the eye (uveal tract) but with other locations including the central nervous system, lung, liver, bones and endocrine glands, and may be associated with considerable morbidity.

Neoplasm

An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumour).


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(per page)
PMID (PMCID)
22864545
(3474918)
 FEMALE Infant
Infantile juvenile xanthogranuloma of the chest wall mimicking mesenchymal hamartoma: report of a case.
Masui D, Fukahori S, Asagiri K, Tanaka Y, Ishii S, Kojima S, Yoshida M, Komatsuzaki N, Tanikawa K, Kage M, Nagata S, Yagi M.
Pediatr Surg Int. 2012;28(11):1137-40.
Juvenile xanthogranuloma (JXG) is essentially a benign neoplasm arising from any site on the body; however, there has so far been only one report of JXG located on the chest wall involving a rib.
19602070
 FEMALE Child
Histiocyte-rich pleomorphic mastocytoma: an uncommon variant mimicking juvenile xanthogranuloma and Langerhans cell histiocytosis.
Tran DT, Jokinen CH, Argenyi ZB.
J Cutan Pathol. 2009;36(11):1215-20.
Awareness of this unusual morphologic variant is also important as the histologic features may mimic such childhood neoplasms as juvenile xanthogranuloma and Langerhans cell histiocytosis.
12049182
 MALE Infant
Benign isolated fibrohistiocytic tumor arising from the central nervous system. Considerations about two cases.
Pimentel J, Fernandes A, Tavora L, Miguens J, Lobo Antunes J.
Clin Neuropathol. 2002;21(3):93-8.
Other benign, isolated, intracranial fibrohistiocytic neoplasms, namely the juvenile xanthogranuloma, can harbor a clinical, morphological and immunohistochemical profile overlapping the one of the BFH.