Juvenile xanthogranuloma

Juvenile xanthogranuloma is the most common type of non-Langerhans cell histiocytosis (see this term) characterized by the occurrence of one or more reddish or yellowish self-limiting and benign papules or nodules of several millimeters in diameter, usually appearing on the head and neck (but sometimes on the extremities and trunk) during the first year of life (or rarely in adulthood) and usually regressing spontaneously. Extracutaneous involvement has also been reported, involving most commonly the eye (uveal tract) but with other locations including the central nervous system, lung, liver, bones and endocrine glands, and may be associated with considerable morbidity.

Papule

A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point.


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PMID (PMCID)
29641718
(5871383)
 FEMALE Adult
Dermoscopy in the diagnosis of juvenile xanthogranuloma.
Oliveira TE, Tarle RG, Mesquita LAF.
An Bras Dermatol. 2018;93(1):138-140.
We report the use of dermoscopy ("setting sun" pattern) as an adjuvant tool in the diagnosis of juvenile xanthogranuloma in a female patient presenting with a 2-month history of a pre-auricular papule.
29209883
 MALE Child
Disseminated juvenile xanthogranuloma occurring after treatment of Langerhans cell histiocytosis: a case report.
Lee TK, Jung TY, Baek HJ, Kim SK, Lee KH, Yun SJ.
Childs Nerv Syst. 2018;34(4):765-770.
After 4years and 4months off treatment, he developed multiple, subcutaneous, asymptomatic, and yellowish variable-sized papules on his face, posterior neck, and back, which were pathologically diagnosed as juvenile xanthogranuloma (JXG).
28583250
 FEMALE Infant
Oral Juvenile Xanthogranuloma: Report of Two Cases.
Israel MS, Carlos R, Pires FR.
Pediatr Dent. 2017;39(3):238-240.
The purpose of the present study was to report two cases of oral juvenile xanthogranuloma affecting the lower lip of a 14-year-old girl and the soft palate of a second 14-month-old girl, both present as yellowish papules.
28329596
 FEMALE Infant
Coalescing nodules on the trunk of an infant: juvenile xanthogranuloma 'en plaque'.
Hau JT, Langevin K.
Dermatol Online J. 2016;22(10):.
Juvenile xanthogranuloma (JXG) is a benign, non-Langerhans cell histiocytosis, which commonly manifests as a solitary papule or nodule in infants and young children.
25227151
 MIXED_SAMPLE Infant
Case series of volar juvenile xanthogranuloma: clinical observation of a peripheral rim of hyperkeratosis.
Mervak J, Amadi U, Khandpur R, Ha Lan TT, Hristov A, Do TT, Maier L, Wang F.
J Dermatol. 2014;41(10):933-6.
Juvenile xanthogranuloma is a benign histiocytic tumor predominantly occurring in children as yellowish papules on the head and trunk.
22957538
 MALE Infant
Clustered juvenile xanthogranuloma.
Messeguer F, Agusti-Mejias A, Colmenero I, Hernandez-Martin A, Torrelo A.
Pediatr Dermatol. 2013;30(6):e295-6.
Clustered or agminated juvenile xanthogranuloma (JXG) is an unusual form of JXG characterized by multiple reddish-brown or yellowish papules and nodules in a coalescent pattern.
21980990
 MALE
Juvenile xanthogranuloma with lichenoid appearance.
Yoneda K, Demitsu T, Kubota Y.
J Dermatol. 2012;39(5):462-5.
We report a 2-year-old boy who presented with generalized eruption of a mixture of micronodular and macronodular juvenile xanthogranuloma with a large number of widely distributed lichenoid papules.
19969387
 MALE Infant
A child with coexistent juvenile xanthogranuloma and Langerhans cell histiocytosis.
Yu H, Kong J, Gu Y, Ling B, Xi Z, Yao Z.
J Am Acad Dermatol. 2010;62(2):329-32.
A biopsy specimen from one of the yellowish papules showed histopathologic and immunohistochemical changes of both juvenile xanthogranuloma and Langerhans cell histiocytosis.
3120613
 MALE Infant
Niemann-Pick disease and juvenile xanthogranuloma. Are they related?
Wood WS, Dimmick JE, Dolman CL.
Am J Dermatopathol. 1987;9(5):433-7.
We describe a case of Niemann-Pick disease with multiple cutaneous papules and nodules resembling juvenile xanthogranuloma.