Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.

Hypogonadism

A decreased functionality of the gonad.


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PMID (PMCID)
8141136
 MALE Middle Aged
Case report: Castleman disease in association with POEMS.
Adelman HM, Cacciatore ML, Pascual JF, Mike JM, Alberts WM, Wallach PM.
Am J Med Sci. 1994;307(2):112-4.
The physician caring for a patient with Castleman disease should be alert to the development of multiple endocrine deficiencies, including primary hypogonadism, diabetes mellitus, hypothyroidism, and adrenal insufficiency.