Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.

Adrenal insufficiency

Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands.


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PMID (PMCID)
8141136
 MALE Middle Aged
Case report: Castleman disease in association with POEMS.
Adelman HM, Cacciatore ML, Pascual JF, Mike JM, Alberts WM, Wallach PM.
Am J Med Sci. 1994;307(2):112-4.
The physician caring for a patient with Castleman disease should be alert to the development of multiple endocrine deficiencies, including primary hypogonadism, diabetes mellitus, hypothyroidism, and adrenal insufficiency.