Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.

Edema

An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.


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PMID (PMCID)
28291506
 FEMALE Adult
Immunotactoid glomerulopathy leading to the discovery of POEMS syndrome
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Philipponnet C, Kemeny JL, Garrouste C, Soubrier M, Heng AE.
Clin Nephrol. 2017;87(6):310-315.
At the same time, a POEMS syndrome diagnosis (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin abnormalities) was confirmed in light of the following: 1) IgG 954 monoclonal gammopathy, 2) axonal neuropathy, 3) osteosclerosis, 4) melanoderma, 5) hepatosplenomegaly and adenopathies, 6) Castleman disease, and 7) edema.
19670534
 MALE Child
Poems syndrome--a rare variant of plasma cell dyscrasia. Case report and review of literature.
Goranova-Marinova VS, Chernev KG, Goranov SE.
Folia Med (Plovdiv). 2009;51(2):5-11.
We present a case of POEMS syndrome in a 47-year-old male patient who initially presented with edema of the lower limbs, moderate lymphadenopathy, hepatosplenomegaly, histological findings of Castleman disease with marked sinusoidal angioproliferation in the lymph nodes and multiple osteosclerotic lesions.
17665027
 MALE Adult
POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin lesions) syndrome: a South America's report.
Leite AC, Nascimento OJ, Lima MA, Andrada-Serpa MJ.
Arq Neuropsiquiatr. 2007;65(2B):516-20.
Several other associated conditions such as sclerotic bone lesions, Castleman disease, low-grade fever, edema and hematologic disorders are usually seen.