Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.

Polyneuropathy

A generalized disorder of peripheral nerves.


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PMID (PMCID)
31119772
 OTHER
Adenopathy and extensive skin patch overlying a plasmacytoma with unusual histologic findings in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome and Castleman disease.
Dagrosa AT, Cowdrey MCE, LeBlanc RE, Lansigan F, Kaur P, Carter JB.
J Cutan Pathol. 2019;:.
Adenopathy and extensive skin patch overlying a plasmacytoma with unusual histologic findings in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome and Castleman disease.
30301456
(6176504)
 MALE
Castleman disease of the hyaline vascular variant transforming to POEMS syndrome as endpoint: a case report.
Ge Y, Da Q, Dai Y.
BMC Neurol. 2018;18(1):169.
We report a rare case that triggers the need to consider POEMS syndrome diagnosis for patients carrying Castleman disease and polyneuropathy.
30301456
(6176504)
 MALE
Castleman disease of the hyaline vascular variant transforming to POEMS syndrome as endpoint: a case report.
Ge Y, Da Q, Dai Y.
BMC Neurol. 2018;18(1):169.
Here we report a 66-year-old man with treated Castleman disease developing with sequential presence of endocrinopathy polyneuropathy, skin changes, organomegaly and extravascular volume overload within 18years, which was finally confirmed as POEMS syndrome by positive monoclonal protein.
28291506
 FEMALE Adult
Immunotactoid glomerulopathy leading to the discovery of POEMS syndrome
.
Philipponnet C, Kemeny JL, Garrouste C, Soubrier M, Heng AE.
Clin Nephrol. 2017;87(6):310-315.
At the same time, a POEMS syndrome diagnosis (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin abnormalities) was confirmed in light of the following: 1) IgG 954 monoclonal gammopathy, 2) axonal neuropathy, 3) osteosclerosis, 4) melanoderma, 5) hepatosplenomegaly and adenopathies, 6) Castleman disease, and 7) edema.
21566409
 MALE Middle Aged
[POEMS syndrome diagnosed by detection of M-protein on immunofixation and increased level of vascular endothelial growth factor].
Hattori Y, Taguchi J, Imai N, Wasano K, Matsuura S, Koharazawa H, Ishigatsubo Y, Fujisawa S.
Rinsho Ketsueki. 2011;52(4):219-22.
A 48-year-old male with Castleman disease developed symptoms typical of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal-protein and skin changes) but M-protein was not detected by immunoelec-trophoresis.
19546057
 MALE Middle Aged
Pituitary macroadenoma in a patient with POEMS syndrome in conjunction with Castleman disease: first report of a case and review of related literature.
Bruno C, Fleck JD, Cavaghan MK.
Endocr Pract. 2010;16(1):97-101.
POEMS syndrome is a rare paraneoplastic condition, commonly associated with Castleman disease, that manifests with progressive distal polyneuropathy and a monoclonal plasma cell disorder, often accompanied by endocrinopathy, organomegaly, skin changes, sclerotic bone lesions, ascites, erythrocytosis, and thrombocytosis.
12873182
 FEMALE Middle Aged
Human herpesvirus-8-positive microvenular hemangioma in POEMS syndrome.
Hudnall SD, Chen T, Brown K, Angel T, Schwartz MR, Tyring SK.
Arch Pathol Lab Med. 2003;127(8):1034-6.
We report a case of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome in a 55-year-old African American woman in which human herpesvirus-8 (HHV-8) was demonstrated within rare lymphocytes in a Castleman disease lymph node biopsy and numerous endothelial cells and lymphocytes in a microvenular hemangioma skin biopsy.
8141136
 MALE Middle Aged
Case report: Castleman disease in association with POEMS.
Adelman HM, Cacciatore ML, Pascual JF, Mike JM, Alberts WM, Wallach PM.
Am J Med Sci. 1994;307(2):112-4.
Castleman disease, or angiofollicular lymph node hyperplasia, and POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes), are associated and can lead to a clinical conundrum.