Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.

Thrombocytosis

Increased numbers of platelets in the peripheral blood.


Total: 2

                       


(per page)
PMID (PMCID)
19546057
 MALE Middle Aged
Pituitary macroadenoma in a patient with POEMS syndrome in conjunction with Castleman disease: first report of a case and review of related literature.
Bruno C, Fleck JD, Cavaghan MK.
Endocr Pract. 2010;16(1):97-101.
Our current patient had all 5 classic features of POEMS syndrome along with some diagnostic elements of Castleman disease, sclerotic bone lesions, and thrombocytosis.
19546057
 MALE Middle Aged
Pituitary macroadenoma in a patient with POEMS syndrome in conjunction with Castleman disease: first report of a case and review of related literature.
Bruno C, Fleck JD, Cavaghan MK.
Endocr Pract. 2010;16(1):97-101.
POEMS syndrome is a rare paraneoplastic condition, commonly associated with Castleman disease, that manifests with progressive distal polyneuropathy and a monoclonal plasma cell disorder, often accompanied by endocrinopathy, organomegaly, skin changes, sclerotic bone lesions, ascites, erythrocytosis, and thrombocytosis.