Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.

Anemia

A reduction in erythrocytes volume or hemoglobin concentration.


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PMID (PMCID)
30906603
 OTHER
Castleman Disease in a Patient with Common Variable Immunodeficiency.
Ricciardi L, Furci F, Ieni A, Macri A.
Case Reports Immunol. 2019;2019:5476383.
Castleman disease (CD) is a systemic disease clinically characterized by diffuse lymphadenopathy, splenomegaly, anemia, and systemic inflammatory symptoms.
26387507
 FEMALE
Anemia and autoimmunity markers in an adolescent with Castleman disease.
Fretzayas A, Stasinopoulou A, Moustaki M, Stefos E, Kaniouras G, Nicolaidou P.
Pediatr Int. 2015;57(6):1199-201.
This case emphasizes the need to investigate thoroughly for the underlying cause of anemia of inflammation and to include Castleman disease in the differential diagnosis, on the measurement of IL-6.
26387507
 FEMALE
Anemia and autoimmunity markers in an adolescent with Castleman disease.
Fretzayas A, Stasinopoulou A, Moustaki M, Stefos E, Kaniouras G, Nicolaidou P.
Pediatr Int. 2015;57(6):1199-201.
Anemia and autoimmunity markers in an adolescent with Castleman disease.
24367988
 FEMALE Child
Iron-refractory microcytic anemia as the presenting feature of unicentric Castleman disease in children.
Chandrakasan S, Bakeer N, Mo JQ, Cost C, Quinn CT.
J Pediatr. 2014;164(4):928-30.
Surgical resection cured the anemia and the Castleman disease.
24367988
 FEMALE Child
Iron-refractory microcytic anemia as the presenting feature of unicentric Castleman disease in children.
Chandrakasan S, Bakeer N, Mo JQ, Cost C, Quinn CT.
J Pediatr. 2014;164(4):928-30.
A diagnostic clue to Castleman disease is an elevated concentration of interleukin-6 in blood, which causes anemia by inducing the expression of the iron-regulatory hormone hepcidin.