Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.

Unexplained fevers

Episodes of fever for which no infectious cause can be identified.


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PMID (PMCID)
8956935
 FEMALE
Iron therapy resistant microcytic anaemia in a 13-year-old girl with Castleman disease.
De Heer-Groen TA, Prakken AB, Bax NM, van Dijken PJ.
Eur J Pediatr. 1996;155(12):1015-7.
Castleman disease should be considered in cases of chronic fatigue, unexplained fever, microcytic anaemia and hypergammaglobulinaemia.