Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.

Lymphadenopathy

Enlargment (swelling) of a lymph node.


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PMID (PMCID)
30906603
 OTHER
Castleman Disease in a Patient with Common Variable Immunodeficiency.
Ricciardi L, Furci F, Ieni A, Macri A.
Case Reports Immunol. 2019;2019:5476383.
Castleman disease (CD) is a systemic disease clinically characterized by diffuse lymphadenopathy, splenomegaly, anemia, and systemic inflammatory symptoms.
29626596
 OTHER
Renal histology in a patient with TAFRO syndrome: a case report.
Mizuno H, Sekine A, Oguro M, Oshima Y, Kawada M, Sumida K, Yamanouchi M, Hayami N, Suwabe T, Hiramatsu R, Hasegawa E, Hoshino J, Sawa N, Fujii T, Takaichi K, Ohashi K, Ubara Y.
Hum Pathol. 2018;82:258-263.
Autopsy showed hyaline vascular-type Castleman disease-like lymphadenopathy and reticulin myelofibrosis with an increase of megakaryocytes.
29668470
 MALE Middle Aged
Secondary Hodgkin Lymphoma and Myelodysplastic Syndrome (MDS) After Paclitaxel-Carboplatin Treatment in a Patient with Small Cell Lung Cancer.
Petrusevska M, Stavridis IP, Mladenovska K, Petrushevska G.
Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2017;38(3):97-103.
After four years of treatment with the combined chemotherapy, the patient presented inguinal lymphadenopathy and enlarged lymph nodes and histopathology rapport was suggestive for plasmacytoid variant of Castleman disease.
26490523
 FEMALE Middle Aged
Multicentric Castleman Disease with Monoclonal Incomplete IgH Restriction: A Rare Coexistence.
Goyal G, Kendric K, Silberstein PT, Caponetti GC, Vivekanandan R.
J Clin Exp Hematop. 2015;55(2):103-8.
As treatment for Castleman disease, she was administered a combination of rituximab and etoposide, which led to a reduction in lymphadenopathy.
24048114
(4391510)
 MALE Adult
Diffuse lymphadenopathy as the presenting manifestation of systemic lupus erythematosus.
Smith LW, Gelber AC, Petri M.
J Clin Rheumatol. 2013;19(7):397-9.
The differential diagnosis of lymphadenopathy relevant to rheumatologists includes Kikuchi histiocytic necrotizing lymphadenitis, Castleman disease, syphilis, tuberculosis, sarcoidosis, and lymphoma.
21940235
 MALE Middle Aged
Cutaneous and systemic plasmacytosis vs. cutaneous plasmacytic castleman disease: review and speculations about pathogenesis.
Haque M, Hou JS, Hisamichi K, Tamada K, Cusack CA, Abdelmalek M, Brown RE, Vonderheid EC.
Clin Lymphoma Myeloma Leuk. 2011;11(6):453-61.
Cutaneous and systemic plasmacytosis (C/SP), human herpes virus-8 (HHV8), negative multicentric plasmacytic Castleman disease (MPCD), and idiopathic plasmacytic lymphadenopathy are polyclonal plasma cell proliferations of unknown etiology that predominantly affect Asian individuals.
19670534
 MALE Child
Poems syndrome--a rare variant of plasma cell dyscrasia. Case report and review of literature.
Goranova-Marinova VS, Chernev KG, Goranov SE.
Folia Med (Plovdiv). 2009;51(2):5-11.
We present a case of POEMS syndrome in a 47-year-old male patient who initially presented with edema of the lower limbs, moderate lymphadenopathy, hepatosplenomegaly, histological findings of Castleman disease with marked sinusoidal angioproliferation in the lymph nodes and multiple osteosclerotic lesions.
9628975
 MIXED_SAMPLE Adult
[Kikuchi's disease and proteinaceous lymphoadenopathy in 4 patients with HIV infection].
Cossu A, Lissia A, Cossu S, Marras V, Tanda F, Massarelli G.
Pathologica. 1998;90(1):20-6.
In the lymphadenopathy occurring in the acquired immunodeficiency syndrome (AIDS) and the AIDS related complex (ARC), consistent histologic patterns have been described with some variants thereof, such as angioimmunoblastic lymphadenopathy-like or Castleman disease-like.