Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.

Follicular hyperplasia

Lymphadenopathy (enlargement of lymph nodes) owing to hyperplasia of follicular (germinal) centers.


Total: 2

                       


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PMID (PMCID)
20194090
 MALE Middle Aged
Multicentric Castleman disease: report of rare disease in Kuwait.
Mohammad BA, Al-Brahim N, Kunjhibava S, Ahmad M, Ahmad M.
Gulf J Oncolog. 2009;(6):48-50.
Lymph node biopsy showed follicular hyperplasia with inter-follicular plasma cells infiltrate with a typical morphology of plasma cell variant of Castleman disease.
18573783
 MALE Middle Aged
Lymphoplasmacytic infiltrate of regional lymph nodes in Kuttner's tumor (chronic sclerosing sialadenitis): a report of 3 cases.
Kojima M, Miyawaki S, Takada S, Kashiwabara K, Igarashi T, Nakamura S.
Int J Surg Pathol. 2008;16(3):263-8.
The present 3 cases indicated that regional lymph node of Kuttner's tumor may show reactive follicular hyperplasia and prominent interfollicular plasmacytosis and should be differentiated from various benign and malignant lymphoproliferative disorders including systemic rheumatic disease, plasma cell type of Castleman disease, and lymph node involvement of marginal B-cell lymphoma of the mucosa-associated lymphoid tissue type showing prominent plasma cell differentiation.