Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.

Retroperitoneal fibrosis



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PMID (PMCID)
18603855
 MALE Middle Aged
[Retroperitoneal fibrosis and Castleman disease in two patients with high IgG4 levels].
Miwa I, Maruyama Y, Kageoka M, Nagata K, Ohata A, Noda Y, Ikeya K, Matsui T, Koda K, Watanabe F.
Nihon Shokakibyo Gakkai Zasshi. 2008;105(7):1087-92.
We recently experienced two cases of retroperitoneal fibrosis and Castleman disease presenting high IgG4 levels without evident pancreatic lesions.
18603855
 MALE Middle Aged
[Retroperitoneal fibrosis and Castleman disease in two patients with high IgG4 levels].
Miwa I, Maruyama Y, Kageoka M, Nagata K, Ohata A, Noda Y, Ikeya K, Matsui T, Koda K, Watanabe F.
Nihon Shokakibyo Gakkai Zasshi. 2008;105(7):1087-92.
It is necessary to acknowledge that retroperitoneal fibrosis and Castleman disease, with or without pancreatic lesions, may have aspects of IgG4-related systemic disease and that the measurement of serum IgG4 and tissue immunostaining for IgG4 should be considered for diagnosing and treating the conditions.
18603855
 MALE Middle Aged
[Retroperitoneal fibrosis and Castleman disease in two patients with high IgG4 levels].
Miwa I, Maruyama Y, Kageoka M, Nagata K, Ohata A, Noda Y, Ikeya K, Matsui T, Koda K, Watanabe F.
Nihon Shokakibyo Gakkai Zasshi. 2008;105(7):1087-92.
[Retroperitoneal fibrosis and Castleman disease in two patients with high IgG4 levels].