Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.

Anasarca

An extreme form of generalized edema with widespread and massive edema due to effusion of fluid into the extracellular space.


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PMID (PMCID)
30009125
(6038051)
 OTHER
Successful rituximab treatment of TAFRO syndrome with pathological findings of glomerular endothelial damage.
Noda Y, Saka Y, Kato A, Mimura T, Naruse T.
Clin Nephrol Case Stud. 2018;6:16-20.
Thrombocytopenia, anasarca, fever, renal insufficiency, and organomegaly constitute TAFRO syndrome, a variant of Castleman disease.