Dermatitis herpetiformis

A chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. It may also appear as a consequence of gluten intolerance.

Edema

An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.

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PMID (PMCID)
7695010	MIXED_SAMPLE	Adult
	Intracorneal nuclear dust aggregates in dermatitis herpetiformis. A clue to diagnosis.
	Williams BT, Hampton MT, Mitchell DF, Metcalf JS. Am J Dermatopathol. 1995;17(1):48-52.
	Dermatitis herpetiformis has a characteristic histologic pattern consisting of subepidermal blisters often containing fibrin, infiltrates of neutrophils and nuclear dust at tips of dermal papillae, and papillary dermal edema.