Dermatitis herpetiformis

A chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. It may also appear as a consequence of gluten intolerance.

Villous atrophy

The enteric villi are atrophic or absent.


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PMID (PMCID)
3732905
 FEMALE Middle Aged
Monozygous twins concordant for duodenojejunal villous atrophy and dermatitis herpetiformis.
Green ST, Natarajan S, Connor JM, Forrest JA.
Gut. 1986;27(8):970-1.
Monozygous twins concordant for duodenojejunal villous atrophy and dermatitis herpetiformis.
7051809
 FEMALE
IgA pseudo-linear deposits in glomerular basement membranes in dermatitis herpetiformis.
Bartoli E, Bosincu L, Costanzi G, Denti S, Olmeo NA, Soggia G.
Am J Clin Pathol. 1982;78(3):377-80.
An 18-year-old-woman, with dermatitis herpetiformis, acute glomerulonephritis, malabsorption and villous atrophy due to massive infiltration of IgA producing plasma cells was studied.
1105763
 MIXED_SAMPLE Middle Aged
Acute abdominal complications of coeliac disease.
Connon JJ, McFarland J, Kelly A, Biggart JD, McLoughlin J.
Scand J Gastroenterol. 1975;10(8):843-6.
The other, a patient with long standing dermatitis herpetiformis, perforated his small intestine at a site involved by both a lymphoma and partial villous atrophy.