Dermatitis herpetiformis

A chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. It may also appear as a consequence of gluten intolerance.

Agranulocytosis

Marked decrease in the number of granulocytes.


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PMID (PMCID)
11508074
 FEMALE Adult
Agranulocytosis--a case report.
Rahman J, Chowdhury SA, Wajed J.
Bangladesh Med Res Counc Bull. 2000;26(2):65-8.
Here we present a case of a 27 years old female who had suffered from agranulocytosis after taking Dapsone, Amitriptyline and Oflacin for treatment of Dermatitis Herpetiformis.
8761086
 MALE Middle Aged
[Agranulocytosis induced by dapsone prescribed for dermatitis herpetiformis].
Machet L, Callens A, Mercier E, Gargot S, Lorette G, Vaillant L.
Ann Dermatol Venereol. 1996;123(5):328-30.
Nevertheless, when dapsone is prescribed for dermatitis herpetiformis, the risk of agranulocytosis increases 25-fold reaching 1/400.
8761086
 MALE Middle Aged
[Agranulocytosis induced by dapsone prescribed for dermatitis herpetiformis].
Machet L, Callens A, Mercier E, Gargot S, Lorette G, Vaillant L.
Ann Dermatol Venereol. 1996;123(5):328-30.
[Agranulocytosis induced by dapsone prescribed for dermatitis herpetiformis].