Dermatitis herpetiformis

A chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. It may also appear as a consequence of gluten intolerance.

Allergy

An allergy is an immune response or reaction to substances that are usually not harmful.


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(per page)
PMID (PMCID)
26951355
FEMALE Adult
A lethal case of the dapsone hypersensitivity syndrome involving the myocardium.
Hoogeveen RM, van der Bom T, de Boer HH, Thurlings RM, Wind BS, de Vries HJ, van Lent AU, Beuers U, van der Wal AC, Nellen FJ.
Neth J Med. 2016;74(2):89-92.
In the Netherlands dapsone is used for the treatment of dermatitis herpetiformis, leprosy and Pneumocystis jiroveci pneumonia and prophylaxis in case of cotrimoxazole allergy.