Diencephalic syndrome

Diencephalic syndrome (DS) is a rare condition characterized by profound emaciation and failure to thrive (with normal caloric intake and normal linear growth), hyperalertness, hyperkinesia and euphoria, in the presence of hypothalamic tumors.

Cachexia

Severe weight loss, wasting of muscle, loss of appetite, and general debility related to a chronic disease.


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PMID (PMCID)
8501572
 FEMALE Infant
Increased energy expenditure in a patient with diencephalic syndrome.
Vlachopapadopoulou E, Tracey KJ, Capella M, Gilker C, Matthews DE.
J Pediatr. 1993;122(6):922-4.
This result suggests that the weight loss and cachexia of the diencephalic syndrome are the result of abnormally increased energy expenditure.
1570947
 FEMALE Infant
[A case report of Russel's diencephalic cachexia].
Gallet M, Leke L, Kremp O, Kochert F, Rosat P, Laurent C, Deramont H, Risbourg B.
Ann Pediatr (Paris). 1992;39(3):189-93.
Although cytokines such as TNF alpha are currently incriminated in the pathophysiology of cachexia induced by a number of conditions, they have not yet been studied in diencephalic syndrome of infancy.