Diencephalic syndrome

Diencephalic syndrome (DS) is a rare condition characterized by profound emaciation and failure to thrive (with normal caloric intake and normal linear growth), hyperalertness, hyperkinesia and euphoria, in the presence of hypothalamic tumors.

Euphoria

A sense of intense joy or happiness that is beyond what would be expected under the given circumstances.


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PMID (PMCID)
26337554
(4559913)
 MALE Infant
An infant with hyperalertness, hyperkinesis, and failure to thrive: a rare diencephalic syndrome due to hypothalamic anaplastic astrocytoma.
Stival A, Lucchesi M, Farina S, Buccoliero AM, Castiglione F, Genitori L, de Martino M, Sardi I.
BMC Cancer. 2015;15:616.
Diencephalic Syndrome is a rare clinical condition of failure to thrive despite a normal caloric intake, hyperalertness, hyperkinesis, and euphoria usually associated with low-grade hypothalamic astrocytomas.
23052462
 FEMALE Infant
Intermediate pilomyxoid astrocytoma and diencephalic syndrome: imaging findings.
Nakamura OK, Pinho Mda C, Odone Filho V, Rosemberg S.
Einstein (Sao Paulo). 2012;10(2):236-8.
Due to its topography, it may present developmental delay in childhood and diencephalic syndrome, characterized by extreme weight loss, lack of fat accumulation, hyperactivity, euphoria and alertness.
1811904
 MALE Infant
Diencephalic syndrome with long-term survival.
Leary PM, Bonnici F.
Cent Afr J Med. 1991;37(7):207-10.
Characteristic features of the diencephalic syndrome are normal activity and a state of euphoria in a profoundly marasmic child.
686781
 FEMALE Infant
Increased urinary catecholamines in an infant with the diencephalic syndrome.
Karpathios T, Nicolaidou P, Fretzagias A, Haidas S, Thomaidis T.
Arch Dis Child. 1978;53(6):511-3.
Some of the symptoms of the diencephalic syndrome such as euphoria, irritability, skin pallor, and hypertension may be the result of catecholamine secretion.