Paget disease of the nipple

Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.

Melanoma

The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea).


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PMID (PMCID)
25473229
(4252674)
 OTHER
Pigmented mammary paget disease misdiagnosed as malignant melanoma.
Lee JH, Kim TH, Kim SC, Kim YC, Roh MR.
Ann Dermatol. 2014;26(6):747-50.
Herein, we report a case of pigmented mammary Paget disease misdiagnosed as malignant melanoma.
23661948
(3643369)
 OTHER
Pigmented Paget's disease of nipple: A diagnostic challenge on cytology.
Vani B, Thejaswini M, Srinivasamurthy V, Rao MS.
J Cytol. 2013;30(1):68-70.
Based on the physical examination and cytological features, a diagnosis of malignant melanoma with a differential of Paget's disease of the nipple was made.
17576941
 FEMALE
Pigmented mammary Paget disease: dermoscopic, in vivo reflectance-mode confocal microscopic, and immunohistochemical study of a case.
Longo C, Fantini F, Cesinaro AM, Bassoli S, Seidenari S, Pellacani G.
Arch Dermatol. 2007;143(6):752-4.
Pigmented mammary Paget disease represents a rare variant of mammary Paget disease that clinically and dermoscopically simulates a melanoma.
17576941
 FEMALE
Pigmented mammary Paget disease: dermoscopic, in vivo reflectance-mode confocal microscopic, and immunohistochemical study of a case.
Longo C, Fantini F, Cesinaro AM, Bassoli S, Seidenari S, Pellacani G.
Arch Dermatol. 2007;143(6):752-4.
We report a case of pigmented mammary Paget disease mimicking a melanoma and describe the dermoscopic, reflectance-mode confocal microscopic, histological, and immunohistochemical features.
17576941
 FEMALE
Pigmented mammary Paget disease: dermoscopic, in vivo reflectance-mode confocal microscopic, and immunohistochemical study of a case.
Longo C, Fantini F, Cesinaro AM, Bassoli S, Seidenari S, Pellacani G.
Arch Dermatol. 2007;143(6):752-4.
Pigmented mammary Paget disease represents a rare variant of mammary Paget disease that clinically and dermoscopically simulates a melanoma.
12140433
 FEMALE Adult
Pigmented mammary Paget disease and pigmented epidermotropic metastases from breast carcinoma.
Requena L, Sangueza M, Sangueza OP, Kutzner H.
Am J Dermatopathol. 2002;24(3):189-98.
Pigmented mammary Paget disease and pigmented epidermotropic metastatic breast carcinoma should be differentiated from melanoma clinical and histopathologically.
11427802
 MALE
[Pigmented Paget's disease of the male nipple].
Menet E, Vabres P, Brecheteau P, Bonneau-Herve F, Duport G, Levillain P, Larregue M, Babin P.
Ann Dermatol Venereol. 2001;128(5):649-52.
A case of Paget's disease of the nipple in a 76 year-old male is reported, clinically mimicking a malignant melanoma because of massive pigmentation.
2856457
 FEMALE
Paget's disease of the nipple simulating malignant melanoma in a black woman.
Peison B, Benisch B.
Am J Dermatopathol. 1985;7 Suppl:165-9.
Paget's disease of the nipple simulating malignant melanoma in a black woman.