Paget disease of the nipple

Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.

Breast carcinoma

The presence of a carcinoma of the breast.


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PMID (PMCID)
30008979
(6043634)
 OTHER
Bilateral mammary Paget disease in a young adult female.
Babu B, Dev B, Mohanapriya T, Shalini CNS.
Radiol Case Rep. 2018;13(3):586-591.
Mammary Paget disease is an uncommon malignancy of the breast that presents with ulceration or eczema of the nipple and is almost always associated with an underlying breast carcinoma.
20432750
 FEMALE Middle Aged
Misleading presentations of malignant breast diseases--role of clinical cytology.
Kaic G, Stoos-Veic T, Ostovic KT, Vojnovic J, Vidovic L, Lambasa S, Harim V, Ajdukovic R, Stanec S, Budi S.
Coll Antropol. 2010;34(1):193-5.
In the first case--Paget's disease of the nipple, there was no obvious clinical and radiological evidence of breast cancer, while the second case--primary non-Hodgkin lymphoma of the breast imitated advanced breast carcinoma.
18950495
(2584629)
 OTHER
Mucinous breast carcinoma presenting as Paget's disease of the nipple in a man: a case report.
Peschos D, Tsanou E, Dallas P, Charalabopoulos K, Kanaris C, Batistatou A.
Diagn Pathol. 2008;3:42.
Mucinous breast carcinoma presenting as Paget's disease of the nipple in a man: a case report.
12140433
 FEMALE Adult
Pigmented mammary Paget disease and pigmented epidermotropic metastases from breast carcinoma.
Requena L, Sangueza M, Sangueza OP, Kutzner H.
Am J Dermatopathol. 2002;24(3):189-98.
Pigmented mammary Paget disease and pigmented epidermotropic metastatic breast carcinoma should be differentiated from melanoma clinical and histopathologically.
12140433
 FEMALE Adult
Pigmented mammary Paget disease and pigmented epidermotropic metastases from breast carcinoma.
Requena L, Sangueza M, Sangueza OP, Kutzner H.
Am J Dermatopathol. 2002;24(3):189-98.
Two cases of pigmented mammary Paget disease and all cases of pigmented epidermotropic metastatic breast carcinoma showed the proliferation of dendritic melanocytes arranged as solitary units along the dermoepidermal junction and intermingled with the neoplastic cells of the mammary carcinoma in the superficial dermis.
12140433
 FEMALE Adult
Pigmented mammary Paget disease and pigmented epidermotropic metastases from breast carcinoma.
Requena L, Sangueza M, Sangueza OP, Kutzner H.
Am J Dermatopathol. 2002;24(3):189-98.
We report three examples of pigmented mammary Paget disease and six cases of pigmented epidermotropic metastases from breast carcinoma, which were studied from both the histopathologic and immunohistochemical points of view.
6311473
 MALE Middle Aged
Klinefelter's syndrome associated with breast carcinoma and Paget's disease of the nipple.
Moshakis V, Fordyce MJ, Griffiths JD.
Clin Oncol. 1983;9(3):257-61.
Klinefelter's syndrome associated with breast carcinoma and Paget's disease of the nipple.